WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 592048
CAS#: 1360562-98-6
Description: XZH-5 is a STAT3 inhibitor.
MedKoo Cat#: 592048
Name: XZH-5
CAS#: 1360562-98-6
Chemical Formula: C22.H25F6N5O4
Exact Mass: 537.1811
Molecular Weight: 537.46
Elemental Analysis: C, 49.16; H, 4.69; F, 21.21; N, 13.03; O, 11.91
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: XZH-5; XZH 5; XZH5;
IUPAC/Chemical Name: 2(S)-{2(S)-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-3-methyl-butyrylamino}-3-(1-methyl- 1H-imidazol-4-yl)-propionic acid methyl este
InChi Key: SYSZGLKKVMTFTM-KRWDZBQOSA-N
InChi Code: InChI=1S/C22H25F6N5O4/c1-12(2)5-18(34)33(17(19(35)37-4)9-16-10-32(3)11-29-16)31-20(36)30-15-7-13(21(23,24)25)6-14(8-15)22(26,27)28/h6-8,10-12,17H,5,9H2,1-4H3,(H2,30,31,36)/t17-/m0/s1
SMILES Code: O=C(OC)[C@@H](N(NC(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)C(CC(C)C)=O)CC2=CN(C)C=N2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 537.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Daka P, Liu A, Karunaratne C, Csatary E, Williams C, Xiao H, Lin J, Xu Z, Page RC, Wang H. Design, synthesis and evaluation of XZH-5 analogues as STAT3 inhibitors. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55. doi: 10.1016/j.bmc.2015.01.025. Epub 2015 Jan 22. PubMed PMID: 25698618.
2: Liu A, Liu Y, Jin Z, Hu Q, Lin L, Jou D, Yang J, Xu Z, Wang H, Li C, Lin J. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells. PLoS One. 2012;7(10):e46624. doi: 10.1371/journal.pone.0046624. Epub 2012 Oct 3. PubMed PMID: 23056374; PubMed Central PMCID: PMC3463519.
3: Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer Sci. 2011 Jul;102(7):1381-7. doi: 10.1111/j.1349-7006.2011.01932.x. Epub 2011 May 5. PubMed PMID: 21435102.
4: Liu Y, Liu A, Xu Z, Yu W, Wang H, Li C, Lin J. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis. 2011 May;16(5):502-10. doi: 10.1007/s10495-011-0578-0. PubMed PMID: 21311975.
