WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597509
CAS#: 32163-95-4
Description: O-Phosphohydroxylysine is a phosphoamino acid.
MedKoo Cat#: 597509
Name: O-Phosphohydroxylysine
CAS#: 32163-95-4
Chemical Formula: C6H15N2O6P
Exact Mass: 242.0668
Molecular Weight: 242.16
Elemental Analysis: C, 29.76; H, 6.24; N, 11.57; O, 39.64; P, 12.79
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: O-Phosphohydroxylysine; 5-Hydroxylysine phosphate;
IUPAC/Chemical Name: (2S)-2,6-diamino-5-(phosphonooxy)hexanoic acid
InChi Key: WLPXLNNUXMDSPG-AKGZTFGVSA-N
InChi Code: InChI=1S/C6H15N2O6P/c7-3-4(14-15(11,12)13)1-2-5(8)6(9)10/h4-5H,1-3,7-8H2,(H,9,10)(H2,11,12,13)/t4?,5-/m0/s1
SMILES Code: N[C@@H](CCC(OP(O)(O)=O)CN)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 242.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Dorland L, Duran M, de Bree PK, Smith GR, Horvath A, Tibosch AS, Wadman SK. O-phosphohydroxylysinuria: a new inborn error of metabolism? Clin Chim Acta. 1990 May;188(3):221-6. PubMed PMID: 2387074.
2: Hubálek F, Edmondson DE, Pohl J. Synthesis and characterization of a collagen model delta-O-phosphohydroxylysine-containing peptide. Anal Biochem. 2002 Jul 1;306(1):124-34. PubMed PMID: 12069423.
3: Tsai CH, Henderson LM. Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase. J Biol Chem. 1974 Sep 25;249(18):5784-9. PubMed PMID: 4412716.
4: Kulik W, Heerma W, Dorland L, de Bree PK, Duran M. Fast-atom bombardment tandem mass spectrometry of phosphohydroxylysine and related phosphohydroxy amino acids. Rapid Commun Mass Spectrom. 1989 Mar;3(3):76-8. PubMed PMID: 2520228.
5: Tsai CH, Henderson LM. Degradation of O-phosphohydroxylysine in rat liver. Purification and properties of 2-aminoadipic semialdehyde dehydrogenase. J Biol Chem. 1974 Sep 25;249(18):5790-2. PubMed PMID: 4369906.
6: Piggott MJ, Attwood PV. Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N (1)-phosphotryptophan and S-phosphocysteine. Amino Acids. 2017 Aug;49(8):1309-1323. doi: 10.1007/s00726-017-2446-x. Epub 2017 Jun 3. Review. PubMed PMID: 28578504.
7: Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J Biol Chem. 2012 Mar 2;287(10):7246-55. doi: 10.1074/jbc.M111.323485. Epub 2012 Jan 12. PubMed PMID: 22241472; PubMed Central PMCID: PMC3293546.
