WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597477

CAS#: 17355-10-1

Description: Tyrosylleucine is a dipeptide composed of tyrosine and leucine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an 'Expected' metabolite.

Chemical Structure

CAS# 17355-10-1

Theoretical Analysis

MedKoo Cat#: 597477
Name: Tyrosylleucine
CAS#: 17355-10-1
Chemical Formula: C15H22N2O4
Exact Mass: 294.158
Molecular Weight: 294.35
Elemental Analysis: C, 61.21; H, 7.53; N, 9.52; O, 21.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Tyrosylleucine; Tyr-leu; L-Tyrosyl-L-leucine;

IUPAC/Chemical Name: L-tyrosyl-L-leucine


InChi Code: InChI=1S/C15H22N2O4/c1-9(2)7-13(15(20)21)17-14(19)12(16)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8,16H2,1-2H3,(H,17,19)(H,20,21)/t12-,13-/m0/s1

SMILES Code: CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=C(O)C=C1)N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 294.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Moreira IP, Sasselli IR, Cannon DA, Hughes M, Lamprou DA, Tuttle T, Ulijn RV. Enzymatically activated emulsions stabilised by interfacial nanofibre networks. Soft Matter. 2016 Mar 7;12(9):2623-31. doi: 10.1039/c5sm02730f. Epub 2016 Feb 1. PubMed PMID: 26905042.

2: Mizushige T, Kanegawa N, Yamada A, Ota A, Kanamoto R, Ohinata K. Aromatic amino acid-leucine dipeptides exhibit anxiolytic-like activity in young mice. Neurosci Lett. 2013 May 24;543:126-9. doi: 10.1016/j.neulet.2013.03.043. Epub 2013 Apr 6. PubMed PMID: 23570730.

3: Domingues P, Fonseca C, Reis A, Domingues MR. Identification of isomeric spin adducts of Leu-Tyr and Tyr-Leu free radicals using liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2012 Jan;26(1):51-60. doi: 10.1002/bmc.1624. Epub 2011 Mar 23. PubMed PMID: 21432862.

4: Kanegawa N, Suzuki C, Ohinata K. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604. doi: 10.1016/j.febslet.2009.12.008. Epub 2009 Dec 23. PubMed PMID: 20005875.

5: Chen Y, Zhang L, Cai Z, Chen G. Dynamic pH junction-sweeping for on-line focusing of dipeptides in capillary electrophoresis with laser-induced fluorescence detection. Analyst. 2011 May 7;136(9):1852-8. doi: 10.1039/c0an00744g. Epub 2011 Mar 11. PubMed PMID: 21394345.

6: Mullally MM, Meisel H, FitzGerald RJ. Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol Chem Hoppe Seyler. 1996 Apr;377(4):259-60. PubMed PMID: 8737991.

7: Fonseca C, Domingues MR, Simões C, Amado F, Domingues P. Reactivity of Tyr-Leu and Leu-Tyr dipeptides: identification of oxidation products by liquid chromatography-tandem mass spectrometry. J Mass Spectrom. 2009 May;44(5):681-93. doi: 10.1002/jms.1543. PubMed PMID: 19125397.

8: Gardner ML, Mitchell CJ. Studies on the absorption of the pancreatic function test peptide, N-benzoyl-L-tyrosyl-p-aminobenzoic acid, and related compounds by isolated rat small intestine. Q J Exp Physiol. 1981 Jan;66(1):17-24. PubMed PMID: 6973773.