WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563191
Description: S23757 is a selective ligand of imidazoline 1 receptor (I1R).
MedKoo Cat#: 563191
Chemical Formula: C10H11FN2
Exact Mass: 178.0906
Molecular Weight: 178.21
Elemental Analysis: C, 67.40; H, 6.22; F, 10.66; N, 15.72
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: S23757; S-23757; S 23757;
IUPAC/Chemical Name: 2-(2-Fluoro-5-methylphenyl)-4,5-dihydro-1H-imidazole
InChi Key: NXWHIOQBGWJKSH-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H11FN2/c1-7-2-3-9(11)8(6-7)10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H,12,13)
SMILES Code: CC1=CC=C(F)C(C2=NCCN2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 178.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Bousquet P, Greney H, Bruban V, Schann S, Ehrhardt JD, Monassier L, Feldman J. I(1) imidazoline receptors involved in cardiovascular regulation: where are we and where are we going? Ann N Y Acad Sci. 2003 Dec;1009:228-33. Review. PubMed PMID: 15028592.
2: Sy GY, Bruban V, Bousquet P, Feldman J. Nitric oxide discriminates the sites and mechanisms of action of centrally acting anti-hypertensive drugs in rabbits. Neuropharmacology. 2002 Dec;43(8):1330-8. PubMed PMID: 12527483.
3: Bruban V, Estato V, Schann S, Ehrhardt JD, Monassier L, Renard P, Scalbert E, Feldman J, Bousquet P. Evidence for synergy between alpha(2)-adrenergic and nonadrenergic mechanisms in central blood pressure regulation. Circulation. 2002 Mar 5;105(9):1116-21. PubMed PMID: 11877365.
4: Bruban V, Feldman J, Greney H, Dontenwill M, Schann S, Jarry C, Payard M, Boutin J, Scalbert E, Pfeiffer B, Renard P, Vanhoutte P, Bousquet P. Respective contributions of alpha-adrenergic and non-adrenergic mechanisms in the hypotensive effect of imidazoline-like drugs. Br J Pharmacol. 2001 May;133(2):261-6. PubMed PMID: 11350862; PubMed Central PMCID: PMC1572786.