N-Acetylmelphalanylleucine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597472

CAS#: 347400-96-8

Description: N-Acetylmelphalanylleucine is a bioactive chemical.


Price and Availability

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N-Acetylmelphalanylleucine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597472
Name: N-Acetylmelphalanylleucine
CAS#: 347400-96-8
Chemical Formula: C21H31Cl2N3O4
Exact Mass: 459.1692
Molecular Weight: 460.39
Elemental Analysis: C, 54.79; H, 6.79; Cl, 15.40; N, 9.13; O, 13.90


Synonym: N-Acetylmelphalanylleucine; N-Acetyl-melphalan-L-leucine;

IUPAC/Chemical Name: ((S)-2-acetamido-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoyl)-L-leucine

InChi Key: RNGMBZXFENQKJV-OALUTQOASA-N

InChi Code: InChI=1S/C21H31Cl2N3O4/c1-14(2)12-19(21(29)30)25-20(28)18(24-15(3)27)13-16-4-6-17(7-5-16)26(10-8-22)11-9-23/h4-7,14,18-19H,8-13H2,1-3H3,(H,24,27)(H,25,28)(H,29,30)/t18-,19-/m0/s1

SMILES Code: CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=C(N(CCCl)CCCl)C=C1)NC(C)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Larionov LF, Bukharova IK, Shamaeva EM. Toxicity and antineoplastic activity of asalei (ethyl ester of acetyl-sarcolysine-L-leucine). Fed Proc Transl Suppl. 1966 Jan-Feb;25(1):77-8. PubMed PMID: 5215810.

2: Smyth MJ, Pietersz GA, McKenzie IF. Selective enhancement of antitumor activity of N-acetyl melphalan upon conjugation to monoclonal antibodies. Cancer Res. 1987 Jan 1;47(1):62-9. PubMed PMID: 3791221.