WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597413

CAS#: 73684-80-7

Description: Pyroglutaminyl-seryl-leucinamide is a bioactive chemical.

Chemical Structure

CAS# 73684-80-7

Theoretical Analysis

MedKoo Cat#: 597413
Name: Pyroglutaminyl-seryl-leucinamide
CAS#: 73684-80-7
Chemical Formula: C14H24N4O5
Exact Mass: 328.17
Molecular Weight: 328.360
Elemental Analysis: C, 51.21; H, 7.37; N, 17.06; O, 24.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Pyroglutaminyl-seryl-leucinamide; Pyr-ser-leu-NH2; Thyrotropin releasing hormone-AN; Trh-AN;

IUPAC/Chemical Name: (S)-N-((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-hydroxy-1-oxopropan-2-yl)-5-oxopyrrolidine-2-carboxamide


InChi Code: InChI=1S/C14H24N4O5/c1-7(2)5-9(12(15)21)17-14(23)10(6-19)18-13(22)8-3-4-11(20)16-8/h7-10,19H,3-6H2,1-2H3,(H2,15,21)(H,16,20)(H,17,23)(H,18,22)/t8-,9-,10-/m0/s1

SMILES Code: CC(C)C[C@@H](C(N)=O)NC([C@H](CO)NC([C@H](CC1)NC1=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 328.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Burov IuV, Vedernikova NN, Borisova IP, Shvachkin IuP, Smirnova AP. [Influence of thyroliberin and its analogs with different hormonal activity on the pharmacological effects of ethanol]. Biull Eksp Biol Med. 1983 May;95(5):42-4. Russian. PubMed PMID: 6405823.

2: Babichev VN, Samsonova VM, Airapetiants MG, Kolomeĭtseva IA, Shvachkin IuP. [Neuroendocrine effect of thyroliberin and its analogs]. Probl Endokrinol (Mosk). 1981 Jul-Aug;27(4):35-8. Russian. PubMed PMID: 6794024.

3: Babichev VN, Samsonova VM, Airapetyants MG, Kolomeitseva IA, Shvachkin YuP, Smirnova AP. Neuroendocrine effects of thyroliberin and its analogs. Neurosci Behav Physiol. 1982 Sep-Oct;12(5):394-7. PubMed PMID: 6820125.

4: Babichev VN, Ignatkov VYa, Shvachkin YuP, Smirnova AP. Comparative analysis of the sensitivity of single neurons of the central nervous system to thyrotropin-releasing hormone and its structural analog. Neurosci Behav Physiol. 1981 Jul-Aug;11(4):385-8. PubMed PMID: 6806677.

5: Samsonova VM, Babichev VN, Shvachkin IuP, Smirnova AP. [Comparative study of the neurotropic and hormonal activity of thyrotropin releasing hormone and its analogs]. Probl Endokrinol (Mosk). 1980 Mar-Apr;26(2):48-52. Russian. PubMed PMID: 6769109.