Iduronate 2-sulfate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597368

CAS#: 89846-17-3

Description: Iduronate 2-sulfate is a sulfatase enzyme associated with Hunter syndrome.


Chemical Structure

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Iduronate 2-sulfate
CAS# 89846-17-3

Theoretical Analysis

MedKoo Cat#: 597368
Name: Iduronate 2-sulfate
CAS#: 89846-17-3
Chemical Formula: C6H10O10S
Exact Mass: 273.9995
Molecular Weight: 274.19
Elemental Analysis: C, 26.28; H, 3.68; O, 58.35; S, 11.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Iduronate 2-sulfate;

IUPAC/Chemical Name: (2R,3S,4S,5R)-2,3,4-trihydroxy-6-oxo-5-(sulfooxy)hexanoic acid

InChi Key: PURMPUDWXOWORS-SKNVOMKLSA-N

InChi Code: InChI=1S/C6H10O10S/c7-1-2(16-17(13,14)15)3(8)4(9)5(10)6(11)12/h1-5,8-10H,(H,11,12)(H,13,14,15)/t2-,3+,4-,5+/m0/s1

SMILES Code: O[C@H]([C@@H](O)C(O)=O)[C@@H]([C@@H](OS(O)(=O)=O)C=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 274.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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5: Sista RS, Wang T, Wu N, Graham C, Eckhardt A, Winger T, Srinivasan V, Bali D, Millington DS, Pamula VK. Multiplex newborn screening for Pompe, Fabry, Hunter, Gaucher, and Hurler diseases using a digital microfluidic platform. Clin Chim Acta. 2013 Sep 23;424:12-8. doi: 10.1016/j.cca.2013.05.001. Epub 2013 May 7. PubMed PMID: 23660237; PubMed Central PMCID: PMC3926752.

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13: Lualdi S, Di Rocco M, Corsolini F, Spada M, Bembi B, Cotugno G, Battini R, Stroppiano M, Gabriela Pittis M, Filocamo M. Identification of nine new IDS alleles in mucopolysaccharidosis II. Quantitative evaluation by real-time RT-PCR of mRNAs sensitive to nonsense-mediated and nonstop decay mechanisms. Biochim Biophys Acta. 2006 Apr;1762(4):478-84. Epub 2006 Feb 9. PubMed PMID: 16495038.

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15: Bao X, Pavão MS, Dos Santos JC, Sugahara K. A functional dermatan sulfate epitope containing iduronate(2-O-sulfate)alpha1-3GalNAc(6-O-sulfate) disaccharide in the mouse brain: demonstration using a novel monoclonal antibody raised against dermatan sulfate of ascidian Ascidia nigra. J Biol Chem. 2005 Jun 17;280(24):23184-93. Epub 2005 Apr 22. PubMed PMID: 15849184.

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