Iditol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597366

CAS#: 488-45-9

Description: Iditol is a rare sugar alcohol (polyol).


Chemical Structure

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Iditol
CAS# 488-45-9

Theoretical Analysis

MedKoo Cat#: 597366
Name: Iditol
CAS#: 488-45-9
Chemical Formula: C6H14O6
Exact Mass: 182.079
Molecular Weight: 182.17
Elemental Analysis: C, 39.56; H, 7.75; O, 52.69

Price and Availability

Size Price Availability Quantity
100.0mg USD 280.0 2 Weeks
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Synonym: Iditol; L-Iditol;

IUPAC/Chemical Name: (2S,3R,4R,5S)-hexane-1,2,3,4,5,6-hexaol

InChi Key: FBPFZTCFMRRESA-UNTFVMJOSA-N

InChi Code: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5+,6+/m0/s1

SMILES Code: OC[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)CO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 182.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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Reconstitution Calculator

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1: Mukherjee K, Narindoshvili T, Raushel FM. Discovery of a Kojibiose Phosphorylase in Escherichia coli K-12. Biochemistry. 2018 May 15;57(19):2857-2867. doi: 10.1021/acs.biochem.8b00392. Epub 2018 Apr 30. PubMed PMID: 29684280; PubMed Central PMCID: PMC5953851.

2: Tanimoto T. [Enzymological Studies on the Mechanisms of Pathogenesis of Diabetic Complications]. Yakugaku Zasshi. 2018;138(3):405-415. doi: 10.1248/yakushi.17-00195. Review. Japanese. PubMed PMID: 29503433.

3: Fikry EM, Hasan WA, Mohamed EG. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32(2). doi: 10.1002/jbt.22029. Epub 2018 Jan 5. PubMed PMID: 29315975.

4: Şengül B, Beydemir Ş. The interactions of cephalosporins on polyol pathway enzymes from sheep kidney. Arch Physiol Biochem. 2018 Feb;124(1):35-44. doi: 10.1080/13813455.2017.1358749. Epub 2017 Jul 31. PubMed PMID: 28758816.

5: Zou X, Lin J, Mao X, Zhao S, Ren Y. Biosynthesis of L-Erythrose by Assembly of Two Key Enzymes in Gluconobacter oxydans. J Agric Food Chem. 2017 Sep 6;65(35):7721-7725. doi: 10.1021/acs.jafc.7b02201. Epub 2017 Aug 24. PubMed PMID: 28707464.

6: Duarte RM, Sadauskas-Henrique H, de Almeida-Val VMF, Val AL, Nice HE, Gagnon MM. Biomarker responses and PAH ratios in fish inhabiting an estuarine urban waterway. Environ Toxicol. 2017 Oct;32(10):2305-2315. doi: 10.1002/tox.22447. Epub 2017 Jul 14. PubMed PMID: 28707373.

7: Mohammad F E, Hasan WA, Mohamed EG. Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2017 Jul;31(7). doi: 10.1002/jbt.21896. Epub 2017 Apr 19. PubMed PMID: 28422384.

8: Cui ZM, Zhang JD, Fan XJ, Zheng GW, Chang HH, Wei WL. Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-phenyl-1,2-ethanediol by two substrate tolerance carbonyl reductases with cofactor regeneration. J Biotechnol. 2017 Feb 10;243:1-9. doi: 10.1016/j.jbiotec.2016.12.016. Epub 2016 Dec 21. PubMed PMID: 28011130.

9: Fredslund F, Otten H, Gemperlein S, Poulsen JC, Carius Y, Kohring GW, Lo Leggio L. Structural characterization of the thermostable Bradyrhizobium japonicumD-sorbitol dehydrogenase. Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt 11):846-852. Epub 2016 Oct 27. PubMed PMID: 27827356.

10: Wang J, Zhang RR, Gao GQ, Ma MY, Chen H. Cold tolerance and silencing of three cold-tolerance genes of overwintering Chinese white pine larvae. Sci Rep. 2016 Oct 5;6:34698. doi: 10.1038/srep34698. PubMed PMID: 27703270; PubMed Central PMCID: PMC5050449.

11: Tripathi M, Singh AP, Gupta G, Rajender S. Concomitant and discrete expressions of aldose reductase and sorbitol dehydrogenase in the male reproductive tract. Acta Histochem. 2016 Oct;118(8):776-783. doi: 10.1016/j.acthis.2016.09.008. Epub 2016 Sep 29. PubMed PMID: 27692814.

12: Wan H, Kang Z, Li J, Zhou J. [Effect of high 2-KLG concentration on expression of pivotal genes involved in 2-KLG synthesis in Gluconobacter oxydans WSH-003]. Wei Sheng Wu Xue Bao. 2016 Oct 4;56(10):1656-63. Chinese. PubMed PMID: 29741828.

13: Kim TS, Patel SK, Selvaraj C, Jung WS, Pan CH, Kang YC, Lee JK. A highly efficient sorbitol dehydrogenase from Gluconobacter oxydans G624 and improvement of its stability through immobilization. Sci Rep. 2016 Sep 16;6:33438. doi: 10.1038/srep33438. PubMed PMID: 27633501; PubMed Central PMCID: PMC5025769.

14: Winges A, Garcia TB, Prager P, Wiedemann P, Kohen L, Bringmann A, Hollborn M. Osmotic expression of aldose reductase in retinal pigment epithelial cells: involvement of NFAT5. Graefes Arch Clin Exp Ophthalmol. 2016 Dec;254(12):2387-2400. Epub 2016 Sep 14. PubMed PMID: 27628063.

15: Steinhauser CB, Landers M, Myatt L, Burghardt RC, Vallet JL, Bazer FW, Johnson GA. Fructose Synthesis and Transport at the Uterine-Placental Interface of Pigs: Cell-Specific Localization of SLC2A5, SLC2A8, and Components of the Polyol Pathway. Biol Reprod. 2016 Nov;95(5):108. Epub 2016 Aug 17. PubMed PMID: 27535960.

16: Sadauskas-Henrique H, Braz-Mota S, Duarte RM, de Almeida-Val VM. Influence of the natural Rio Negro water on the toxicological effects of a crude oil and its chemical dispersion to the Amazonian fish Colossoma macropomum. Environ Sci Pollut Res Int. 2016 Oct;23(19):19764-75. doi: 10.1007/s11356-016-7190-3. Epub 2016 Jul 13. PubMed PMID: 27411537.

17: Naidu PB, Sathibabu Uddandrao VV, Naik RR, Pothani S, Munipally PK, Meriga B, Begum MS, Varatharaju C, Pandiyan R, Saravanan G. Effects of S-Allylcysteine on Biomarkers of the Polyol Pathway in Rats with Type 2 Diabetes. Can J Diabetes. 2016 Oct;40(5):442-448. doi: 10.1016/j.jcjd.2016.03.006. Epub 2016 Jul 1. PubMed PMID: 27373435.

18: Xi W, Zheng H, Zhang Q, Li W. Profiling Taste and Aroma Compound Metabolism during Apricot Fruit Development and Ripening. Int J Mol Sci. 2016 Jun 24;17(7). pii: E998. doi: 10.3390/ijms17070998. PubMed PMID: 27347931; PubMed Central PMCID: PMC4964374.

19: Adamczyk J, Deregowska A, Skoneczny M, Skoneczna A, Natkanska U, Kwiatkowska A, Rawska E, Potocki L, Kuna E, Panek A, Lewinska A, Wnuk M. Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts. Cell Stress Chaperones. 2016 Sep;21(5):849-64. doi: 10.1007/s12192-016-0710-8. Epub 2016 Jun 14. PubMed PMID: 27299603; PubMed Central PMCID: PMC5003802.

20: Yuan J, Wu M, Lin J, Yang L. Combinatorial metabolic engineering of industrial Gluconobacter oxydans DSM2343 for boosting 5-keto-D-gluconic acid accumulation. BMC Biotechnol. 2016 May 17;16(1):42. doi: 10.1186/s12896-016-0272-y. PubMed PMID: 27189063; PubMed Central PMCID: PMC4869267.

Iditol

100.0mg / USD 280.0