WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597331
CAS#: 32159-22-1
Description: Pyroglutamylhistidine is a dipeptide.
MedKoo Cat#: 597331
Name: Pyroglutamylhistidine
CAS#: 32159-22-1
Chemical Formula: C11H14N4O4
Exact Mass: 266.1015
Molecular Weight: 266.25
Elemental Analysis: C, 49.62; H, 5.30; N, 21.04; O, 24.04
Synonym: Pyroglutamylhistidine; Pglu-his;
IUPAC/Chemical Name: ((S)-5-oxopyrrolidine-2-carbonyl)-L-histidine
InChi Key: XFWCSGJOVUQCME-YUMQZZPRSA-N
InChi Code: InChI=1S/C11H14N4O4/c16-9-2-1-7(14-9)10(17)15-8(11(18)19)3-6-4-12-5-13-6/h4-5,7-8H,1-3H2,(H,12,13)(H,14,16)(H,15,17)(H,18,19)/t7-,8-/m0/s1
SMILES Code: O=C(O)[C@H](CC1=CNC=N1)NC([C@H](CC2)NC2=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 266.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Chambery A, Severino V, Di Maro A, D'Aniello A, Ruvo M, Parente A. Quantification of thyrotropin-releasing hormone by liquid chromatography-electrospray mass spectrometry. Amino Acids. 2010 Apr;38(4):1031-41. doi: 10.1007/s00726-009-0311-2. Epub 2009 Jun 13. PubMed PMID: 19526311.
2: Skopicki HA, Zikos D, Sukowski EJ, Fisher KA, Peterson DR. Gentamicin inhibits carrier-mediated dipeptide transport in kidney. Am J Physiol. 1996 Mar;270(3 Pt 2):F531-8. PubMed PMID: 8780257.
3: Skopicki HA, Fisher K, Zikos D, Flouret G, Peterson DR. Low-affinity transport of pyroglutamyl-histidine in renal brush-border membrane vesicles. Am J Physiol. 1989 Nov;257(5 Pt 1):C971-5. PubMed PMID: 2596591.
4: Skopicki HA, Fisher K, Zikos D, Flouret G, Bloch R, Kubillus S, Peterson DR. Carrier-mediated transport of pyroglutamyl-histidine in renal brush border membrane vesicles. Am J Physiol. 1988 Dec;255(6 Pt 1):C822-7. PubMed PMID: 3202151.
