Isoborneol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591878

CAS#: 124-76-5

Description: Borneol is a bicyclic organic compound and a terpene derivative. The hydroxyl group in this compound is placed in an endo position. There are two different enantiomers of borneol. Both d--borneol and l--borneol are found in nature.

Chemical Structure

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Isoborneol
CAS# 124-76-5
Instruction

Theoretical Analysis

MedKoo Cat#: 591878
Name: Isoborneol
CAS#: 124-76-5
Chemical Formula: C10H18O
Exact Mass: 154.14
Molecular Weight: 154.250
Elemental Analysis: C, 77.87; H, 11.76; O, 10.37

Price and Availability

Size Price Availability Quantity
25g USD 350 2 Weeks
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Synonym: Isoborneol; NSC 26350; NSC-26350; NSC26350

IUPAC/Chemical Name: Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1R,2R,4R)-rel-

InChi Key: DTGKSKDOIYIVQL-MRTMQBJTSA-N

InChi Code: InChI=1S/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3/t7-,8-,10+/m1/s1

SMILES Code: O[C@H]1[C@](C2(C)C)(C)CC[C@]2([H])C1

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 154.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yuan X, Fei F, Sun H, Xiao C, Zhao X, Zhang Y, Zheng X. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo. Int J Nanomedicine. 2018 Apr 12;13:2265-2274. doi: 10.2147/IJN.S159789. eCollection 2018. PubMed PMID: 29695905; PubMed Central PMCID: PMC5905822.

2: Song H, Wei M, Zhang N, Li H, Tan X, Zhang Y, Zheng W. Enhanced permeability of blood-brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle. Int J Nanomedicine. 2018 Mar 28;13:1869-1879. doi: 10.2147/IJN.S161237. eCollection 2018. PubMed PMID: 29636606; PubMed Central PMCID: PMC5880572.

3: Liao W, Huang X, Yin Y, Liu B, Zhu R. In vivo microdialysis with ultra performance liquid chromatography-mass spectrometry for analysis of tetramethylpyrazine and its interaction with borneol in rat brain and blood. Biomed Chromatogr. 2018 Jun;32(6):e4210. doi: 10.1002/bmc.4210. Epub 2018 Mar 2. PubMed PMID: 29431191.

4: Ho TJ, Hung CC, Shih TL, Yiin LM, Chen HP. Investigation of borneols sold in Taiwan by chiral gas chromatography. J Food Drug Anal. 2018 Jan;26(1):348-352. doi: 10.1016/j.jfda.2016.10.012. Epub 2016 Dec 1. PubMed PMID: 29389573.

5: Shang L, Feng M, Xu X, Liu F, Ke F, Li W. Co-Occurrence of Microcystins and Taste-and-Odor Compounds in Drinking Water Source and Their Removal in a Full-Scale Drinking Water Treatment Plant. Toxins (Basel). 2018 Jan 2;10(1). pii: E26. doi: 10.3390/toxins10010026. PubMed PMID: 29301296; PubMed Central PMCID: PMC5793113.

6: Cao B, Ni HY, Li J, Zhou Y, Bian XL, Tao Y, Cai CY, Qin C, Wu HY, Chang L, Luo CX, Zhu DY. (+)-Borneol suppresses conditioned fear recall and anxiety-like behaviors in mice. Biochem Biophys Res Commun. 2018 Jan 8;495(2):1588-1593. doi: 10.1016/j.bbrc.2017.12.025. Epub 2017 Dec 6. PubMed PMID: 29223397.

7: Wu JJ, Wang HJ, Yang S, Liu Y, Xu XY. [Borneol promotes catalpol and puerarin crossing through blood-brain barrier in focal cerebral ischemic rats]. Zhongguo Zhong Yao Za Zhi. 2016 Nov;41(21):3988-3995. doi: 10.4268/cjcmm20162117. Chinese. PubMed PMID: 28929686.

8: Wang HY, Zhou F, Yu MM, Jin XH. [Preparation of borneol loaded hollow mesoporous silica nanoparticles and effect on borneol volatility]. Zhongguo Zhong Yao Za Zhi. 2016 Aug;41(15):2809-2813. doi: 10.4268/cjcmm20161510. Chinese. PubMed PMID: 28914020.

9: Jafari E, Ghanbarian G, Bahmanzadegan A. Essential oil composition of aerial parts of Micromeria persica Boiss. from Western of Shiraz, Iran. Nat Prod Res. 2018 Apr;32(8):991-996. doi: 10.1080/14786419.2017.1374270. Epub 2017 Sep 11. PubMed PMID: 28893105.

10: Zou L, Zhang Y, Li W, Zhang J, Wang D, Fu J, Wang P. Comparison of Chemical Profiles, Anti-Inflammatory Activity, and UPLC-Q-TOF/MS-Based Metabolomics in Endotoxic Fever Rats between Synthetic Borneol and Natural Borneol. Molecules. 2017 Aug 31;22(9). pii: E1446. doi: 10.3390/molecules22091446. PubMed PMID: 28858264.

11: Song Y, Chu Y, Ma X, Zheng H, Bai X, Zhou S, Yu B. GC-MS/MS method for the determination and pharmacokinetic analysis of borneol and muscone in rat after the intravenous administration of Xingnaojing injection. J Sep Sci. 2017 Nov;40(21):4264-4271. doi: 10.1002/jssc.201700341. PubMed PMID: 28834206.

12: Yu B, Ruan M, Liang T, Huang SW, Yu Y, Cheng HB, Shen XC. The Synergic Effect of Tetramethylpyrazine Phosphate and Borneol for Protecting Against Ischemia Injury in Cortex and Hippocampus Regions by Modulating Apoptosis and Autophagy. J Mol Neurosci. 2017 Sep;63(1):70-83. doi: 10.1007/s12031-017-0958-1. Epub 2017 Aug 4. PubMed PMID: 28779236.

13: Roth S, Funk I, Hofer M, Sieber V. Chemoenzymatic Synthesis of a Novel Borneol-Based Polyester. ChemSusChem. 2017 Sep 22;10(18):3574-3580. doi: 10.1002/cssc.201701146. Epub 2017 Aug 24. PubMed PMID: 28772002.

14: Gao RQ, Fan J, Tan Q, Guo D, Chen T, He RJ, Li D, Zhang H, Zhang WG. Reliable HPLC separation, vibrational circular dichroism spectra, and absolute configurations of isoborneol enantiomers. Chirality. 2017 Sep;29(9):550-557. doi: 10.1002/chir.22728. Epub 2017 Jul 15. PubMed PMID: 28710844.

15: Zhang QL, Fu BM, Zhang ZJ. Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood-brain barrier permeability. Drug Deliv. 2017 Nov;24(1):1037-1044. doi: 10.1080/10717544.2017.1346002. PubMed PMID: 28687052.

16: Mu J, Gao X, Li Q, Yang X, Yang W, Sun X, Bi K, Zhang H. Vortex-ultrasound-assisted dispersive liquid-liquid microextraction coupled with gas chromatography-mass spectrometry for the analysis of volatile bioactive components and comparative pharmacokinetic study of the herb-herb interactions in Guanxin Shutong Capsule. J Sep Sci. 2017 Aug;40(16):3267-3278. doi: 10.1002/jssc.201700500. Epub 2017 Jul 17. PubMed PMID: 28626996.

17: Basom EJ, Manifold BA, Thielges MC. Conformational Heterogeneity and the Affinity of Substrate Molecular Recognition by Cytochrome P450cam. Biochemistry. 2017 Jun 27;56(25):3248-3256. doi: 10.1021/acs.biochem.7b00238. Epub 2017 Jun 14. PubMed PMID: 28581729; PubMed Central PMCID: PMC5816979.

18: Silva ARST, Scher R, Santos FV, Ferreira SR, Cavalcanti SCH, Correa CB, Bueno LL, Alves RJ, Souza DP, Fujiwara RT, Dolabella SS. Leishmanicidal Activity and Structure-Activity Relationships of Essential Oil Constituents. Molecules. 2017 May 16;22(5). pii: E815. doi: 10.3390/molecules22050815. PubMed PMID: 28509873.

19: Mao Z, Wang X, Liu Y, Huang Y, Liu Y, Di X. Simultaneous determination of seven alkaloids from Rhizoma Corydalis Decumbentis in rabbit aqueous humor by LC-MS/MS: Application to ocular pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 1;1057:46-53. doi: 10.1016/j.jchromb.2017.04.040. Epub 2017 Apr 27. PubMed PMID: 28499206.

20: Yin Y, Cao L, Ge H, Duanmu W, Tan L, Yuan J, Tunan C, Li F, Hu R, Gao F, Feng H. L-Borneol induces transient opening of the blood-brain barrier and enhances the therapeutic effect of cisplatin. Neuroreport. 2017 Jun 14;28(9):506-513. doi: 10.1097/WNR.0000000000000792. PubMed PMID: 28471848.