WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591846

CAS#: 91-63-4

Description: Quinaldine or 2-methylquinoline is an organic compound with the formula CH₃C₉H₆N. It is one of the methyl derivative of a heterocyclic compound quinoline. It is bioactive and is used in the preparation of various dyes.

Chemical Structure

CAS# 91-63-4

Theoretical Analysis

MedKoo Cat#: 591846
Name: 2-Methylquinoline
CAS#: 91-63-4
Chemical Formula: C10H9N
Exact Mass: 143.0735
Molecular Weight: 143.19
Elemental Analysis: Chemical Formula: C10H9N Exact Mass: 143.0735 Molecular Weight: 143.1890 Elemental Analysis: C, 83.88; H, 6.34; N, 9.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 2-Methylquinoline

IUPAC/Chemical Name: 2-Methylquinoline


InChi Code: InChI=1S/C10H9N/c1-8-6-7-9-4-2-3-5-10(9)11-8/h2-7H,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 143.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Bai JY, Xie YZ, Wang CJ, Fang SQ, Cao LN, Wang LL, Jin JY. A Quninolylthiazole Derivatives as an ICT-Based Fluorescent Probe of Hg(II) and its Application in Ratiometric Imaging in Live HeLa Cells. J Fluoresc. 2018 May 28. doi: 10.1007/s10895-018-2241-4. [Epub ahead of print] PubMed PMID: 29808394.

2: Bayrak N. A new family of azanaphthoquinones for antimicrobial evaluation. Chem Cent J. 2018 Feb 23;12(1):21. doi: 10.1186/s13065-018-0388-3. PubMed PMID: 29476277; PubMed Central PMCID: PMC5825353.

3: Rahim A, Shaik SP, Baig MF, Alarifi A, Kamal A. Iodine mediated oxidative cross-coupling of unprotected anilines and heteroarylation of benzothiazoles with 2-methylquinoline. Org Biomol Chem. 2018 Jan 24;16(4):635-644. doi: 10.1039/c7ob02241g. PubMed PMID: 29303199.

4: Ni YL, Hsieh CH, Kim SH, Wang JP, Su CL, Yao CF, Fang K. A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres. Apoptosis. 2017 Oct;22(10):1235-1245. doi: 10.1007/s10495-017-1401-3. PubMed PMID: 28741092.

5: Wang HW, Lu Y, Zhang B, He J, Xu HJ, Kang YS, Sun WY, Yu JQ. Ligand-Promoted Rhodium(III)-Catalyzed ortho-C-H Amination with Free Amines. Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7449-7453. doi: 10.1002/anie.201703300. Epub 2017 May 29. PubMed PMID: 28500664.

6: Siemers AK, Palm WU, Faubel C, Mänz JS, Steffen D, Ruck W. Sources of nitrogen heterocyclic PAHs (N-HETs) along a riverine course. Sci Total Environ. 2017 Jul 15;590-591:69-79. doi: 10.1016/j.scitotenv.2017.03.036. PubMed PMID: 28301813.

7: Liu CY, Hsieh CH, Kim SH, Wang JP, Ni YL, Su CL, Yao CF, Fang K. An indolylquinoline derivative activates DNA damage response and apoptosis in human hepatocellular carcinoma cells. Int J Oncol. 2016 Dec;49(6):2431-2441. doi: 10.3892/ijo.2016.3717. Epub 2016 Oct 5. PubMed PMID: 27748837.

8: Le ST, Yasuoka C, Asahara H, Nishiwaki N. Dual Behavior of Iodine Species in Condensation of Anilines and Vinyl Ethers Affording 2-Methylquinolines. Molecules. 2016 Jun 25;21(7). pii: E827. doi: 10.3390/molecules21070827. PubMed PMID: 27347919.

9: Mesquita LM, André V, Esteves CV, Palmeira T, Berberan-Santos MN, Mateus P, Delgado R. Dinuclear Zinc(II) Macrocyclic Complex as Receptor for Selective Fluorescence Sensing of Pyrophosphate. Inorg Chem. 2016 Mar 7;55(5):2212-9. doi: 10.1021/acs.inorgchem.5b02596. Epub 2016 Feb 12. PubMed PMID: 26871612.

10: Liu CY, Wu PT, Wang JP, Fan PW, Hsieh CH, Su CL, Chiu CC, Yao CF, Fang K. An indolylquinoline derivative promotes apoptosis in human lung cancer cells by impairing mitochondrial functions. Apoptosis. 2015 Nov;20(11):1471-82. doi: 10.1007/s10495-015-1165-6. PubMed PMID: 26349782.

11: Arthur AJ, Karanewsky DS, Liu H, Chi B, Markison S. Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carb oxylic acid. Toxicol Rep. 2015 Sep 3;2:1255-1264. doi: 10.1016/j.toxrep.2015.08.012. eCollection 2015. PubMed PMID: 28962468; PubMed Central PMCID: PMC5598146.

12: Canovese L, Visentin F, Scattolin T, Santo C, Bertolasi V. The addition of bromine and iodine to palladacyclopentadienyl complexes bearing bidentate heteroditopic P-N spectator ligands derived from differently substituted quinolinic frames. The unexpected evolution of the reaction. Dalton Trans. 2015 Sep 7;44(33):15049-58. doi: 10.1039/c5dt01884f. PubMed PMID: 26228761.

13: Xie H, Liao Y, Chen S, Chen Y, Deng GJ. Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines. Org Biomol Chem. 2015 Jul 7;13(25):6944-8. doi: 10.1039/c5ob00915d. Epub 2015 Jun 5. PubMed PMID: 26053552.

14: Amini MM, Fazaeli Y, Mohammadnezhad G, Khavasi HR. Structural and spectroscopic characterizations of tetra-nuclear niobium(V) complexes of quinolinol derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jun 5;144:192-9. doi: 10.1016/j.saa.2015.02.077. Epub 2015 Feb 26. PubMed PMID: 25756687.

15: Qin QP, Chen ZF, Qin JL, He XJ, Li YL, Liu YC, Huang KB, Liang H. Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis. Eur J Med Chem. 2015 Mar 6;92:302-13. doi: 10.1016/j.ejmech.2014.12.052. Epub 2014 Dec 30. PubMed PMID: 25575314.

16: Jiang XJ, Li M, Lu HL, Xu LH, Xu H, Zang SQ, Tang MS, Hou HW, Mak TC. A highly sensitive C3-symmetric Schiff-base fluorescent probe for Cd2+. Inorg Chem. 2014 Dec 15;53(24):12665-7. doi: 10.1021/ic501279y. Epub 2014 Dec 2. PubMed PMID: 25456106.

17: Xiao F, Chen S, Chen Y, Huang H, Deng GJ. Efficient 2-sulfolmethyl quinoline formation from 2-methylquinolines and sodium sulfinates under transition-metal free conditions. Chem Commun (Camb). 2015 Jan 14;51(4):652-4. doi: 10.1039/c4cc07546c. PubMed PMID: 25415851.

18: Siddappa K, Mayana NS. Synthesis, Spectroscopic Characterization, and Biological Evaluation Studies of 5-Bromo-3-(((hydroxy-2-methylquinolin-7-yl)methylene)hydrazono)indolin-2-one and Its Metal (II) Complexes. Bioinorg Chem Appl. 2014;2014:483282. doi: 10.1155/2014/483282. Epub 2014 Oct 12. PubMed PMID: 25371658; PubMed Central PMCID: PMC4209756.

19: Jeon JH, Lee HS. Biofunctional constituent isolated from Citrullus colocynthis fruits and structure-activity relationships of its analogues show acaricidal and insecticidal efficacy. J Agric Food Chem. 2014 Aug 27;62(34):8663-7. doi: 10.1021/jf502536e. Epub 2014 Aug 18. PubMed PMID: 25110971.

20: Ramji R, Wang M, Bhagat AA, Tan Shao Weng D, Thakor NV, Teck Lim C, Chen CH. Single cell kinase signaling assay using pinched flow coupled droplet microfluidics. Biomicrofluidics. 2014 May 19;8(3):034104. doi: 10.1063/1.4878635. eCollection 2014 May. PubMed PMID: 24926389; PubMed Central PMCID: PMC4032411.