Aceglutamide
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MedKoo CAT#: 597275

CAS#: 2490-97-3

Description: Aceglutamide is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain. Aceglutamide functions as a prodrug to glutamine with improved potency and stability. Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition. The drug has shown neuroprotective effects in an animal model of cerebral ischemia.


Chemical Structure

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Aceglutamide
CAS# 2490-97-3

Theoretical Analysis

MedKoo Cat#: 597275
Name: Aceglutamide
CAS#: 2490-97-3
Chemical Formula: C7H12N2O4
Exact Mass: 188.0797
Molecular Weight: 188.18
Elemental Analysis: C, 44.68; H, 6.43; N, 14.89; O, 34.01

Price and Availability

Size Price Availability Quantity
25.0g USD 210.0 2 Weeks
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Synonym: Aceglutamide; Acetylglutamine; NSC 186896; NSC-186896; NSC186896; N(sup2)-Acetyl-L-glutamine;

IUPAC/Chemical Name: acetyl-L-glutamine

InChi Key: KSMRODHGGIIXDV-YFKPBYRVSA-N

InChi Code: InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1

SMILES Code: O=C(N)CC[C@@H](C(O)=O)NC(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 188.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Fang YC, Wan HT, Yu L, Yin F, Yang JH, Zhou HF, He Y. [Pharmacokinetics of main activ ingredients of Guhong injection in cerebral ischemia rats]. Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1940-1945. doi: 10.19540/j.cnki.cjcmm.20180206.001. Chinese. PubMed PMID: 29902908.

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10: Racine SX, Le Toumelin P, Adnet F, Cohen Y, Cupa M, Hantz E, Le Moyec L. N-acetyl functions and acetate detected by nuclear magnetic resonance spectroscopy of urine to detect renal dysfunction following aminoglycoside and/or glycopeptide antibiotic therapy. Nephron Physiol. 2004;97(4):p53-7. PubMed PMID: 15331932.

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12: Coudray-Lucas C, Lasnier E, Renaud F, Ziegler F, Settembre P, Cynober LA, Ekindjian OG. Is alpha-ketoisocaproyl-glutamine a suitable glutamine precursor to sustain fibroblast growth? Clin Nutr. 1999 Feb;18(1):29-33. PubMed PMID: 10459079.

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17: Drago F, D'Agata V, Valerio C, Spadaro F, Raffaele R, Nardo L, Grassi M, Freni V. Memory deficits of aged male rats can be improved by pyrimidine nucleosides and n-acetyl-glutamine. Clin Neuropharmacol. 1990 Aug;13(4):290-6. PubMed PMID: 2208180.

18: Seiki M, Ueki S, Tanaka Y, Soeda M, Hori Y, Aita H, Yoneta T, Morita H, Tagashira E, Okabe S. [Studies on anti-ulcer effects of a new compound, zinc L-carnosine (Z-103)]. Nihon Yakurigaku Zasshi. 1990 May;95(5):257-69. Japanese. PubMed PMID: 2113032.

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