WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597275

CAS#: 2490-97-3

Description: Aceglutamide is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain. Aceglutamide functions as a prodrug to glutamine with improved potency and stability. Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition. The drug has shown neuroprotective effects in an animal model of cerebral ischemia.

Chemical Structure

CAS# 2490-97-3

Theoretical Analysis

MedKoo Cat#: 597275
Name: Aceglutamide
CAS#: 2490-97-3
Chemical Formula: C7H12N2O4
Exact Mass: 188.08
Molecular Weight: 188.180
Elemental Analysis: C, 44.68; H, 6.43; N, 14.89; O, 34.01

Price and Availability

Size Price Availability Quantity
25g USD 250 2 weeks
Bulk inquiry

Synonym: Aceglutamide; Acetylglutamine; NSC 186896; NSC-186896; NSC186896; N(sup2)-Acetyl-L-glutamine; α-N-Acetyl-L-glutamine; N2-Acetylglutamine

IUPAC/Chemical Name: acetyl-L-glutamine


InChi Code: InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1

SMILES Code: O=C(N)CC[C@@H](C(O)=O)NC(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 188.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Fang YC, Wan HT, Yu L, Yin F, Yang JH, Zhou HF, He Y. [Pharmacokinetics of main activ ingredients of Guhong injection in cerebral ischemia rats]. Zhongguo Zhong Yao Za Zhi. 2018 May;43(9):1940-1945. doi: 10.19540/j.cnki.cjcmm.20180206.001. Chinese. PubMed PMID: 29902908.

2: Yu L, Wan HF, Li C, Yang JH, Zhou HF, Wan HT, He Y. Pharmacokinetics of Active Components From Guhong Injection in Normal and Pathological Rat Models of Cerebral Ischemia: A Comparative Study. Front Pharmacol. 2018 May 15;9:493. doi: 10.3389/fphar.2018.00493. eCollection 2018. PubMed PMID: 29867497; PubMed Central PMCID: PMC5962683.

3: Li D, Chen YG, Zhang CJ, Tian J, Li X. Safflower Extract and Aceglutamide Injection Promoting Recovery of Peripheral Innervations via Vascular Endothelial Growth Factor-B Signaling in Diabetic Mice. Chin Med J (Engl). 2017 Dec 5;130(23):2829-2835. doi: 10.4103/0366-6999.219143. PubMed PMID: 29176141; PubMed Central PMCID: PMC5717862.

4: Ai J, Wan H, Shu M, Zhou H, Zhao T, Fu W, He Y. Guhong injection protects against focal cerebral ischemia-reperfusion injury via anti-inflammatory effects in rats. Arch Pharm Res. 2017 May;40(5):610-622. doi: 10.1007/s12272-016-0835-4. Epub 2016 Sep 13. PubMed PMID: 27624481.

5: Zhang R, Yang N, Ji C, Zheng J, Liang Z, Hou CY, Liu YY, Zuo PP. Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2015;33(5):741-59. doi: 10.3233/RNN-150509. PubMed PMID: 26444640.

6: Wang D, Wu S. Development and validation of a RP-HPLC method for the simultaneous determination of aceglutamide and oxiracetam in an injection formulation. J Chromatogr Sci. 2015 May-Jun;53(5):767-70. doi: 10.1093/chromsci/bmu123. Epub 2014 Sep 19. PubMed PMID: 25238766.

7: Pekkala S, Martínez AI, Barcelona B, Yefimenko I, Finckh U, Rubio V, Cervera J. Understanding carbamoyl-phosphate synthetase I (CPS1) deficiency by using expression studies and structure-based analysis. Hum Mutat. 2010 Jul;31(7):801-8. doi: 10.1002/humu.21272. PubMed PMID: 20578160.

8: López-Pedrosa JM, Manzano M, Baxter JH, Rueda R. N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs. Dig Dis Sci. 2007 Mar;52(3):650-8. PubMed PMID: 17253138.

9: Arnaud A, Ramírez M, Baxter JH, Angulo AJ. Absorption of enterally administered N-acetyl-l-glutamine versus glutamine in pigs. Clin Nutr. 2004 Dec;23(6):1303-12. PubMed PMID: 15556252.

10: Racine SX, Le Toumelin P, Adnet F, Cohen Y, Cupa M, Hantz E, Le Moyec L. N-acetyl functions and acetate detected by nuclear magnetic resonance spectroscopy of urine to detect renal dysfunction following aminoglycoside and/or glycopeptide antibiotic therapy. Nephron Physiol. 2004;97(4):p53-7. PubMed PMID: 15331932.

11: Bergana MM, Holton JD, Reyzer IL, Snowden MK, Baxter JH, Pound VL. NMR and MS analysis of decomposition compounds produced from N-acetyl-L-glutamine at low pH. J Agric Food Chem. 2000 Dec;48(12):6003-10. PubMed PMID: 11312773.

12: Coudray-Lucas C, Lasnier E, Renaud F, Ziegler F, Settembre P, Cynober LA, Ekindjian OG. Is alpha-ketoisocaproyl-glutamine a suitable glutamine precursor to sustain fibroblast growth? Clin Nutr. 1999 Feb;18(1):29-33. PubMed PMID: 10459079.

13: Sugahara K, Zhang J, Kodama H. Liquid chromatographic-mass spectrometric analysis of N-acetylamino acids in human urine. J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):15-21. PubMed PMID: 7952062.

14: Gouttebel MC, Astre C, Briand D, Saint-Aubert B, Girardot PM, Joyeux H. Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in the dog. JPEN J Parenter Enteral Nutr. 1992 Mar-Apr;16(2):117-21. PubMed PMID: 1556804.

15: Chen Y. Clinical research on treating senile dementia by combining acupuncture with acupoint-injection. Acupunct Electrother Res. 1992;17(2):61-73. PubMed PMID: 1353652.

16: Varas Lorenzo MJ, López Martínez A, Gordillo Bernal J, Mundet Surroca J. [Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer]. Rev Esp Enferm Dig. 1991 Aug;80(2):91-4. Spanish. PubMed PMID: 1790087.

17: Drago F, D'Agata V, Valerio C, Spadaro F, Raffaele R, Nardo L, Grassi M, Freni V. Memory deficits of aged male rats can be improved by pyrimidine nucleosides and n-acetyl-glutamine. Clin Neuropharmacol. 1990 Aug;13(4):290-6. PubMed PMID: 2208180.

18: Seiki M, Ueki S, Tanaka Y, Soeda M, Hori Y, Aita H, Yoneta T, Morita H, Tagashira E, Okabe S. [Studies on anti-ulcer effects of a new compound, zinc L-carnosine (Z-103)]. Nihon Yakurigaku Zasshi. 1990 May;95(5):257-69. Japanese. PubMed PMID: 2113032.

19: Barrett D, Breslau NA, Wax MB, Molinoff PB, Downs RW Jr. New form of pseudohypoparathyroidism with abnormal catalytic adenylate cyclase. Am J Physiol. 1989 Aug;257(2 Pt 1):E277-83. PubMed PMID: 2548394.

20: Ollenschläger G, Simmel A, Roth E. Availability of glutamine from peptides and acetylglutamine for human tumor-cell cultures. Metabolism. 1989 Aug;38(8 Suppl 1):40-2. PubMed PMID: 2761419.