5,10-Dideazaaminopterin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597271

CAS#: 95674-53-6

Description: 5,10-Dideazaaminopterin is an antileukemic agent.


Chemical Structure

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5,10-Dideazaaminopterin
CAS# 95674-53-6

Theoretical Analysis

MedKoo Cat#: 597271
Name: 5,10-Dideazaaminopterin
CAS#: 95674-53-6
Chemical Formula: C21H22N6O5
Exact Mass: 438.1652
Molecular Weight: 438.44
Elemental Analysis: C, 57.53; H, 5.06; N, 19.17; O, 18.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 5,10-Dideazaaminopterin;

IUPAC/Chemical Name: (4-(2-(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)ethyl)benzoyl)-L-glutamic acid

InChi Key: RGUQKUKRLMXLCM-HNNXBMFYSA-N

InChi Code: InChI=1S/C21H22N6O5/c22-17-14-9-12(10-24-18(14)27-21(23)26-17)2-1-11-3-5-13(6-4-11)19(30)25-15(20(31)32)7-8-16(28)29/h3-6,9-10,15H,1-2,7-8H2,(H,25,30)(H,28,29)(H,31,32)(H4,22,23,24,26,27)/t15-/m0/s1

SMILES Code: Nc1c2cc(CCc3ccc(C(N[C@H](C(O)=O)CCC(O)=O)=O)cc3)cnc2nc(N)n1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 438.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pitts C, Bowen D, Southerland WM. Interaction energy analyses of folate analog binding to human dihydrofolate reductase: contribution of the antifolate substructural regions to complex stability. Drug Metabol Drug Interact. 2000;16(2):99-121. PubMed PMID: 10962643.

2: Piper JR, DeGraw JI, Colwell WT, Johnson CA, Smith RL, Waud WR, Sirotnak FM. Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5,10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in mice. J Med Chem. 1997 Jan 31;40(3):377-84. PubMed PMID: 9022805.

3: Piper JR, Ramamurthy B, Johnson CA, Otter GM, Sirotnak FM. Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl. J Med Chem. 1996 Jan 19;39(2):614-8. PubMed PMID: 8558535.

4: Piper JR, Johnson CA, Otter GM, Sirotnak FM. Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate). J Med Chem. 1992 Aug 7;35(16):3002-6. PubMed PMID: 1501226.

5: DeGraw JI, Christie PH, Colwell WT, Sirotnak FM. Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin. J Med Chem. 1992 Jan 24;35(2):320-4. PubMed PMID: 1732549.

6: Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Thorndike J, Sirotnak FM. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase. J Med Chem. 1988 Nov;31(11):2164-9. PubMed PMID: 3184124.

7: Taylor EC, Harrington PJ, Fletcher SR, Beardsley GP, Moran RG. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. J Med Chem. 1985 Jul;28(7):914-21. PubMed PMID: 4009615.