NDMC101
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MedKoo CAT#: 563143

CAS#: 1308631-40-4

Description: NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 260 2 Weeks
10mg USD 430 2 Weeks
25mg USD 760 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-28. Prices are subject to change without notice.

NDMC101, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563143
Name: NDMC101
CAS#: 1308631-40-4
Chemical Formula: C13H9ClFNO2
Exact Mass: 265.0306
Molecular Weight: 265.66
Elemental Analysis: C, 58.77; H, 3.41; Cl, 13.34; F, 7.15; N, 5.27; O, 12.04


Synonym: NDMC101; NDMC-101; NDMC 101; HS-Cm; HS Cm; HSCm;

IUPAC/Chemical Name: N-(4-Chloro-2-fluorophenyl)-2-hydroxybenzamide

InChi Key: NUQWCDAXACRITO-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H9ClFNO2/c14-8-5-6-11(10(15)7-8)16-13(18)9-3-1-2-4-12(9)17/h1-7,17H,(H,16,18)

SMILES Code: O=C(NC1=CC=C(Cl)C=C1F)C2=CC=CC=C2O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Lee CC, Liu FL, Chen CL, Chen TC, Liu FC, Ahmed Ali AA, Chang DM, Huang HS. Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones. Bioorg Med Chem. 2015 Aug 1;23(15):4522-32. doi: 10.1016/j.bmc.2015.06.007. Epub 2015 Jun 10. PubMed PMID: 26081760.

2: Lee CC, Liu FL, Chen CL, Chen TC, Chang DM, Huang HS. Discovery of 5-(2',4'-difluorophenyl)-salicylanilides as new inhibitors of receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis. Eur J Med Chem. 2015 Jun 15;98:115-26. doi: 10.1016/j.ejmech.2015.05.015. Epub 2015 May 15. PubMed PMID: 26005025.

3: Liou JT, Huang HS, Chiang ML, Lin CS, Yang SP, Ho LJ, Lai JH. A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells. Eur J Pharmacol. 2014 Mar 5;726:124-32. PubMed PMID: 24491838.

4: Cheng CP, Huang HS, Hsu YC, Sheu MJ, Chang DM. A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritis. J Clin Immunol. 2012 Aug;32(4):762-77. doi: 10.1007/s10875-012-9660-9. Epub 2012 Feb 23. PubMed PMID: 22396044.