Monosodium glutamate
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MedKoo CAT#: 597270

CAS#: 142-47-2

Description: Monosodium glutamate is one of the FLAVORING AGENTS used to impart a meat-like flavor. Medically it has been used to reduce blood ammonia levels in ammoniacal azotemia, therapy of hepatic coma, in psychosis, and INTELLECTUAL DISABILITY.

Chemical Structure

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Monosodium glutamate
CAS# 142-47-2
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 597270
Name: Monosodium glutamate
CAS#: 142-47-2
Chemical Formula: C5H8NNaO4
Exact Mass: 0.00
Molecular Weight: 169.112
Elemental Analysis: C, 35.51; H, 4.77; N, 8.28; Na, 13.59; O, 37.84

Price and Availability

Size Price Availability Quantity
100g USD 200
500g USD 330
1kg USD 520
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Synonym: Monosodium glutamate; Sodium glutamate; MSG;

IUPAC/Chemical Name: sodium (S)-2-amino-4-carboxybutanoate

InChi Key: LPUQAYUQRXPFSQ-DFWYDOINSA-M

InChi Code: InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1

SMILES Code: N[C@@H](CCC(O)=O)C([O-])=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Product Data
Instruction:
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Biological target: L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
In vitro activity: The aim of this study was to establish the existence of mGluR7 in normal B lymphocytes and analyse the effect of monosodium glutamate (MSG) on B cell apoptosis in vitro. Cells (10(6)/ml) were cultured with increasing MSG concentrations (1-100 mM). Exposure to increasing MSG concentrations displayed dose dependent effect on B cell viability altogether, ranging from 35% with 100 mM up to 80% with 1 mM MSG. Moreover, the number of late apoptotic cells as well as necrotic cells was dose dependant. Both CD27- as well as CD27+ B cells were affected by MSG. Reference: Bratisl Lek Listy. 2009;110(10):636-40. https://pubmed.ncbi.nlm.nih.gov/20017456/
In vivo activity: MSG (monosodium glutamate)-treated rats had significantly lower pancreatic β-cell mass at 1, 6 and 9 months of study. Islet hemorrhages increased with age in all groups and fibrosis was significantly more frequent in MSG-treated rats at 1 and 3 months. Serum insulin levels and glucose tolerance in MSG-treated and untreated rats were similar at all time points we investigated. Reference: PLoS One. 2015 Jun 29;10(6):e0131595. https://pubmed.ncbi.nlm.nih.gov/26121281/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Water 20.1 118.68

Preparing Stock Solutions

The following data is based on the product molecular weight 169.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Jovic Z, Veselinovic M, Vasic K, Stankovic-Djordjevic D, Cekic S, Milovanovic M, Sarac M. Monosodium glutamate induces apoptosis in naive and memory human B cells. Bratisl Lek Listy. 2009;110(10):636-40. PMID: 20017456. 2. Aruffo C, Ferszt R, Hildebrandt AG, Cérvos-Navarro J. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro. Dev Neurosci. 1987;9(4):228-39. doi: 10.1159/000111625. PMID: 3322785. 3. Albrakati A. Monosodium glutamate induces cortical oxidative, apoptotic, and inflammatory challenges in rats: the potential neuroprotective role of apigenin. Environ Sci Pollut Res Int. 2023 Feb;30(9):24143-24153. doi: 10.1007/s11356-022-23954-1. Epub 2022 Nov 5. PMID: 36334201. 4. Boonnate P, Waraasawapati S, Hipkaeo W, Pethlert S, Sharma A, Selmi C, Prasongwattana V, Cha'on U. Monosodium Glutamate Dietary Consumption Decreases Pancreatic β-Cell Mass in Adult Wistar Rats. PLoS One. 2015 Jun 29;10(6):e0131595. doi: 10.1371/journal.pone.0131595. PMID: 26121281; PMCID: PMC4487683.
In vitro protocol: 1. Jovic Z, Veselinovic M, Vasic K, Stankovic-Djordjevic D, Cekic S, Milovanovic M, Sarac M. Monosodium glutamate induces apoptosis in naive and memory human B cells. Bratisl Lek Listy. 2009;110(10):636-40. PMID: 20017456. 2. Aruffo C, Ferszt R, Hildebrandt AG, Cérvos-Navarro J. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro. Dev Neurosci. 1987;9(4):228-39. doi: 10.1159/000111625. PMID: 3322785.
In vivo protocol: 1. Albrakati A. Monosodium glutamate induces cortical oxidative, apoptotic, and inflammatory challenges in rats: the potential neuroprotective role of apigenin. Environ Sci Pollut Res Int. 2023 Feb;30(9):24143-24153. doi: 10.1007/s11356-022-23954-1. Epub 2022 Nov 5. PMID: 36334201. 2. Boonnate P, Waraasawapati S, Hipkaeo W, Pethlert S, Sharma A, Selmi C, Prasongwattana V, Cha'on U. Monosodium Glutamate Dietary Consumption Decreases Pancreatic β-Cell Mass in Adult Wistar Rats. PLoS One. 2015 Jun 29;10(6):e0131595. doi: 10.1371/journal.pone.0131595. PMID: 26121281; PMCID: PMC4487683.

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