SR-17018
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MedKoo CAT#: 555270

CAS#: 2134602-45-0

Description: SR-17018 is an mu-opioid-receptor (MOR) agonist with an EC50 of 97 nM.


Chemical Structure

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SR-17018
CAS# 2134602-45-0

Theoretical Analysis

MedKoo Cat#: 555270
Name: SR-17018
CAS#: 2134602-45-0
Chemical Formula: C19H18Cl3N3O
Exact Mass: 409.05
Molecular Weight: 410.723
Elemental Analysis: C, 55.56; H, 4.42; Cl, 25.89; N, 10.23; O, 3.90

Price and Availability

Size Price Availability Quantity
10mg USD 150 Ready to ship
25mg USD 250 Ready to ship
50mg USD 450 Ready to ship
100mg USD 750 Ready to ship
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Synonym: SR17018; SR-17018; SR 17018;

IUPAC/Chemical Name: 5,6-dichloro-1-(1-(4-chlorobenzyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one

InChi Key: LAGUDYUGRSQDKS-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26)

SMILES Code: C1=CC(CN2CCC(N3C(=O)NC4C=C(Cl)C(Cl)=CC3=4)CC2)=CC=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: SR-17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.
In vitro activity: To be determined
In vivo activity: Biased agonists, such as SR-17018, may be useful for opioid dependence treatment, while also restoring opioid antinociceptive sensitivity. When chronically administered to mice, SR-17018 did not lead to certain hallmarks of opioid neuronal adaptations seen with morphine. Substitution with SR-17018 in morphine-tolerant mice restored morphine potency and efficacy, whereas the onset of opioid withdrawal was prevented. Reference: Neuropsychopharmacology. 2020 Jan; 45(2): 416–425. https://pubmed.ncbi.nlm.nih.gov/31443104/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.0 14.61

Preparing Stock Solutions

The following data is based on the product molecular weight 410.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Hill R, Sanchez J, Lemel L, Antonijevic M, Hosking Y, Mistry SN, Kruegel AC, Javitch JA, Lane JR, Canals M. Assessment of the potential of novel and classical opioids to induce respiratory depression in mice. Br J Pharmacol. 2023 Dec;180(24):3160-3174. doi: 10.1111/bph.16199. Epub 2023 Aug 22. PMID: 37489013. 2. Grim TW, Schmid CL, Stahl EL, Pantouli F, Ho JH, Acevedo-Canabal A, Kennedy NM, Cameron MD, Bannister TD, Bohn LM. A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal. Neuropsychopharmacology. 2020 Jan;45(2):416-425. doi: 10.1038/s41386-019-0491-8. Epub 2019 Aug 23. PMID: 31443104; PMCID: PMC6901606.
In vitro protocol: To be determined
In vivo protocol: 1. Hill R, Sanchez J, Lemel L, Antonijevic M, Hosking Y, Mistry SN, Kruegel AC, Javitch JA, Lane JR, Canals M. Assessment of the potential of novel and classical opioids to induce respiratory depression in mice. Br J Pharmacol. 2023 Dec;180(24):3160-3174. doi: 10.1111/bph.16199. Epub 2023 Aug 22. PMID: 37489013. 2. Grim TW, Schmid CL, Stahl EL, Pantouli F, Ho JH, Acevedo-Canabal A, Kennedy NM, Cameron MD, Bannister TD, Bohn LM. A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal. Neuropsychopharmacology. 2020 Jan;45(2):416-425. doi: 10.1038/s41386-019-0491-8. Epub 2019 Aug 23. PMID: 31443104; PMCID: PMC6901606.

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Schmid CL, et al. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 2017 Nov 16;171(5):1165-1175.e13.