WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563139

CAS#: 487-49-0

Description: Ononetin is a TRPM3 channel blocker.

Chemical Structure

CAS# 487-49-0

Theoretical Analysis

MedKoo Cat#: 563139
Name: Ononetin
CAS#: 487-49-0
Chemical Formula: C15H14O4
Exact Mass: 258.0892
Molecular Weight: 258.27
Elemental Analysis: C, 69.76; H, 5.46; O, 24.78

Price and Availability

Size Price Availability Quantity
250.0mg USD 310.0 2 Weeks
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Synonym: Ononetin;

IUPAC/Chemical Name: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone


InChi Code: InChI=1S/C15H14O4/c1-19-12-5-2-10(3-6-12)8-14(17)13-7-4-11(16)9-15(13)18/h2-7,9,16,18H,8H2,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 258.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Son GY, Yang YM, Park WS, Chang I, Shin DM. Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. J Dent Res. 2015 Mar;94(3):473-81. doi: 10.1177/0022034514567196. Epub 2015 Jan 16. PubMed PMID: 25595364; PubMed Central PMCID: PMC4814022.

2: Straub I, Krügel U, Mohr F, Teichert J, Rizun O, Konrad M, Oberwinkler J, Schaefer M. Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. Mol Pharmacol. 2013 Nov;84(5):736-50. doi: 10.1124/mol.113.086843. Epub 2013 Sep 4. PubMed PMID: 24006495.

3: Straub I, Mohr F, Stab J, Konrad M, Philipp SE, Oberwinkler J, Schaefer M. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br J Pharmacol. 2013 Apr;168(8):1835-50. doi: 10.1111/bph.12076. PubMed PMID: 23190005; PubMed Central PMCID: PMC3623054.


250.0mg / USD 310.0