10-Formylfolate tetraglutamate

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MedKoo CAT#: 597245

CAS#: 41432-72-8

Description: 10-Formylfolate tetraglutamate, also known as 10-Formylpteroylpentaglutamate or 10-CHOFA(glu)4, is a folate conjugate. 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase.

Chemical Structure

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10-Formylfolate tetraglutamate
CAS# 41432-72-8
Instruction

Theoretical Analysis

MedKoo Cat#: 597245
Name: 10-Formylfolate tetraglutamate
CAS#: 41432-72-8
Chemical Formula: C40H47N11O19
Exact Mass: 985.31
Molecular Weight: 985.870
Elemental Analysis: C, 48.73; H, 4.81; N, 15.63; O, 30.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 10-Formylpteroylpentaglutamate; 10-Formylfolate tetraglutamate; 10-CHOFA(glu)4;

IUPAC/Chemical Name: (3S,8S,13S,18S,23S)-1-(4-(N-((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)formamido)phenyl)-1,6,11,16,21-pentaoxo-2,7,12,17,22-pentaazapentacosane-3,8,13,18,23,25-hexacarboxylic acid

InChi Key: AIQOHUVZTIREKD-KEOOTSPTSA-N

InChi Code: InChI=1S/C40H47N11O19/c41-40-49-32-31(34(60)50-40)43-19(15-42-32)16-51(17-52)20-3-1-18(2-4-20)33(59)48-25(39(69)70)8-13-29(56)46-23(37(65)66)6-11-27(54)44-21(35(61)62)5-10-26(53)45-22(36(63)64)7-12-28(55)47-24(38(67)68)9-14-30(57)58/h1-4,15,17,21-25H,5-14,16H2,(H,44,54)(H,45,53)(H,46,56)(H,47,55)(H,48,59)(H,57,58)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H,69,70)(H3,41,42,49,50,60)/t21-,22-,23-,24-,25-/m0/s1

SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=CN=C3NC(N)=NC(C3=N2)=O)C=O)C=C1)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 985.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pheasant AE, Bates J, Blair JA, Nayyir-Mazhir R. Investigations of tissue folates in normal and malignant tissues. Br J Cancer. 1983 Mar;47(3):393-8. doi: 10.1038/bjc.1983.59. PMID: 6830689; PMCID: PMC2011316.


2: Connor MJ, Blair JA. The identification of the folate conjugates found in rat liver 48 h after the administration of radioactively labelled folate tracers. Biochem J. 1980 Jan 15;186(1):235-42. doi: 10.1042/bj1860235. PMID: 6892769; PMCID: PMC1161524.


3: Connor MJ, Pheasant AE, Blair JA. The identification of p-acetamidobenzoate as a folate degradation product in rat urine. Biochem J. 1979 Mar 15;178(3):795-797. doi: 10.1042/bj1780795. PMID: 454383; PMCID: PMC1186581.