WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597194
CAS#: 85803-34-5
Description: 3'-Fluoroaminopterin is a folic acid antagonist.
MedKoo Cat#: 597194
Name: 3'-Fluoroaminopterin
CAS#: 85803-34-5
Chemical Formula: C19H19FN8O5
Exact Mass: 458.1462
Molecular Weight: 458.41
Elemental Analysis: C, 49.78; H, 4.18; F, 4.14; N, 24.44; O, 17.45
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: 3'-Fluoroaminopterin;
IUPAC/Chemical Name: (4-(((2,4-diaminopteridin-6-yl)methyl)amino)-3-fluorobenzoyl)-L-glutamic acid
InChi Key: SGJMILOGOMOIPG-LBPRGKRZSA-N
InChi Code: InChI=1S/C19H19FN8O5/c20-10-5-8(17(31)26-12(18(32)33)3-4-13(29)30)1-2-11(10)23-6-9-7-24-16-14(25-9)15(21)27-19(22)28-16/h1-2,5,7,12,23H,3-4,6H2,(H,26,31)(H,29,30)(H,32,33)(H4,21,22,24,27,28)/t12-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(N)N=C(N)N=C3N=C2)C(F)=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 458.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Henkin J, Washtien WL. Novel fluorinated antifolates. Enzyme inhibition and cytotoxicity studies on 2'- and 3'-fluoroaminopterin. J Med Chem. 1983 Aug;26(8):1193-6. PubMed PMID: 6410066.
