Mansonone E

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591795

CAS#: 5090-87-9

Description: Mansonone E inhibits topoisomerase II. It has cytotoxic and topo inhibitory potencies.


Chemical Structure

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Mansonone E
CAS# 5090-87-9

Theoretical Analysis

MedKoo Cat#: 591795
Name: Mansonone E
CAS#: 5090-87-9
Chemical Formula: C15H14O3
Exact Mass: 242.943
Molecular Weight: 242.27
Elemental Analysis: C, 74.36; H, 5.82; O, 19.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Mansonone E;

IUPAC/Chemical Name: 3,6,9-trimethyl-2,3-dihydrobenzo[de]chromene-7,8-dione

InChi Key: SYWTYRLIJCHSLJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14O3/c1-7-4-5-10-8(2)6-18-15-9(3)13(16)14(17)11(7)12(10)15/h4-5,8H,6H2,1-3H3

SMILES Code: O=C1C2=C3C(C(C)COC3=C(C)C1=O)=CC=C2C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 242.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nishina A, Miura A, Goto M, Terakado K, Sato D, Kimura H, Hirai Y, Sato H, Phay N. Mansonone E from Mansonia gagei Inhibited α-MSH-Induced Melanogenesis in B16 Cells by Inhibiting CREB Expression and Phosphorylation in the PI3K/Akt Pathway. Biol Pharm Bull. 2018;41(5):770-776. doi: 10.1248/bpb.b17-01045. PubMed PMID: 29709914.

2: Mahalapbutr P, Nutho B, Wolschann P, Chavasiri W, Kungwan N, Rungrotmongkol T. Molecular insights into inclusion complexes of mansonone E and H enantiomers with various β-cyclodextrins. J Mol Graph Model. 2018 Jan;79:72-80. doi: 10.1016/j.jmgm.2017.11.006. Epub 2017 Nov 11. PubMed PMID: 29154164.

3: Huang ZH, Zhuo ST, Li CY, Xie HT, Li D, Tan JH, Ou TM, Huang ZS, Gu LQ, Huang SL. Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors. Eur J Med Chem. 2013 Oct;68:58-71. doi: 10.1016/j.ejmech.2013.07.011. Epub 2013 Aug 1. PubMed PMID: 23968711.

4: Changwong N, Sabphon C, Ingkaninan K, Sawasdee P. Acetyl- and butyryl-cholinesterase inhibitory activities of mansorins and mansonones. Phytother Res. 2012 Mar;26(3):392-6. doi: 10.1002/ptr.3576. Epub 2011 Jul 21. PubMed PMID: 21780212.

5: Boonsri S, Karalai C, Ponglimanont C, Chantrapromma S, Kanjana-Opas A. Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. J Nat Prod. 2008 Jul;71(7):1173-7. doi: 10.1021/np800055q. Epub 2008 Jun 14. PubMed PMID: 18553924.

6: Puckhaber LS, Stipanovic RD. Thespesenone and dehydrooxoperezinone-6-methyl ether, new sesquiterpene quinones from Thespesia populnea. J Nat Prod. 2004 Sep;67(9):1571-3. PubMed PMID: 15387662.

7: Wang D, Xia M, Cui Z, Tashiro S, Onodera S, Ikejima T. Cytotoxic effects of mansonone E and F isolated from Ulmus pumila. Biol Pharm Bull. 2004 Jul;27(7):1025-30. PubMed PMID: 15256734.

8: Tiew P, Ioset JR, Kokpol U, Chavasiri W, Hostettmann K. Antifungal, antioxidant and larvicidal activities of compounds isolated from the heartwood of Mansonia gagei. Phytother Res. 2003 Feb;17(2):190-3. PubMed PMID: 12601687.

9: Nambiar MP, Murugesan R, Wu HC. Inhibition of the cytotoxicity of protein toxins by a novel plant metabolite, mansonone-D. J Cell Physiol. 1998 Jul;176(1):40-9. PubMed PMID: 9618143.

10: Villamil SH, Dubin M, Portela MP, Perissinotti LJ, Brusa MA, Stoppani AO. Semiquinone production by lipophilic o-naphthoquinones. Redox Rep. 1997 Aug;3(4):245-52. doi: 10.1080/13510002.1997.11747117. PubMed PMID: 27415027.

11: Villamil SF, Dubin M, Galeffi C, Stoppani AO. Effects of mansonones on lipid peroxidation, P450 monooxygenase activity, and superoxide anion generation by rat liver microsomes. Biochem Pharmacol. 1990 Nov 15;40(10):2343-51. PubMed PMID: 2173928.