WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 591795
CAS#: 5090-87-9
Description: Mansonone E inhibits topoisomerase II. It has cytotoxic and topo inhibitory potencies.
MedKoo Cat#: 591795
Name: Mansonone E
CAS#: 5090-87-9
Chemical Formula: C15H14O3
Exact Mass: 242.943
Molecular Weight: 242.27
Elemental Analysis: C, 74.36; H, 5.82; O, 19.81
This product is not in stock, which may be available by custom synthesis.
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Synonym: Mansonone E;
IUPAC/Chemical Name: 3,6,9-trimethyl-2,3-dihydrobenzo[de]chromene-7,8-dione
InChi Key: SYWTYRLIJCHSLJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H14O3/c1-7-4-5-10-8(2)6-18-15-9(3)13(16)14(17)11(7)12(10)15/h4-5,8H,6H2,1-3H3
SMILES Code: O=C1C2=C3C(C(C)COC3=C(C)C1=O)=CC=C2C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 242.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nishina A, Miura A, Goto M, Terakado K, Sato D, Kimura H, Hirai Y, Sato H, Phay N. Mansonone E from Mansonia gagei Inhibited α-MSH-Induced Melanogenesis in B16 Cells by Inhibiting CREB Expression and Phosphorylation in the PI3K/Akt Pathway. Biol Pharm Bull. 2018;41(5):770-776. doi: 10.1248/bpb.b17-01045. PubMed PMID: 29709914.
2: Mahalapbutr P, Nutho B, Wolschann P, Chavasiri W, Kungwan N, Rungrotmongkol T. Molecular insights into inclusion complexes of mansonone E and H enantiomers with various β-cyclodextrins. J Mol Graph Model. 2018 Jan;79:72-80. doi: 10.1016/j.jmgm.2017.11.006. Epub 2017 Nov 11. PubMed PMID: 29154164.
3: Huang ZH, Zhuo ST, Li CY, Xie HT, Li D, Tan JH, Ou TM, Huang ZS, Gu LQ, Huang SL. Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors. Eur J Med Chem. 2013 Oct;68:58-71. doi: 10.1016/j.ejmech.2013.07.011. Epub 2013 Aug 1. PubMed PMID: 23968711.
4: Changwong N, Sabphon C, Ingkaninan K, Sawasdee P. Acetyl- and butyryl-cholinesterase inhibitory activities of mansorins and mansonones. Phytother Res. 2012 Mar;26(3):392-6. doi: 10.1002/ptr.3576. Epub 2011 Jul 21. PubMed PMID: 21780212.
5: Boonsri S, Karalai C, Ponglimanont C, Chantrapromma S, Kanjana-Opas A. Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. J Nat Prod. 2008 Jul;71(7):1173-7. doi: 10.1021/np800055q. Epub 2008 Jun 14. PubMed PMID: 18553924.
6: Puckhaber LS, Stipanovic RD. Thespesenone and dehydrooxoperezinone-6-methyl ether, new sesquiterpene quinones from Thespesia populnea. J Nat Prod. 2004 Sep;67(9):1571-3. PubMed PMID: 15387662.
7: Wang D, Xia M, Cui Z, Tashiro S, Onodera S, Ikejima T. Cytotoxic effects of mansonone E and F isolated from Ulmus pumila. Biol Pharm Bull. 2004 Jul;27(7):1025-30. PubMed PMID: 15256734.
8: Tiew P, Ioset JR, Kokpol U, Chavasiri W, Hostettmann K. Antifungal, antioxidant and larvicidal activities of compounds isolated from the heartwood of Mansonia gagei. Phytother Res. 2003 Feb;17(2):190-3. PubMed PMID: 12601687.
9: Nambiar MP, Murugesan R, Wu HC. Inhibition of the cytotoxicity of protein toxins by a novel plant metabolite, mansonone-D. J Cell Physiol. 1998 Jul;176(1):40-9. PubMed PMID: 9618143.
10: Villamil SH, Dubin M, Portela MP, Perissinotti LJ, Brusa MA, Stoppani AO. Semiquinone production by lipophilic o-naphthoquinones. Redox Rep. 1997 Aug;3(4):245-52. doi: 10.1080/13510002.1997.11747117. PubMed PMID: 27415027.
11: Villamil SF, Dubin M, Galeffi C, Stoppani AO. Effects of mansonones on lipid peroxidation, P450 monooxygenase activity, and superoxide anion generation by rat liver microsomes. Biochem Pharmacol. 1990 Nov 15;40(10):2343-51. PubMed PMID: 2173928.
