NSC145021

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597152

CAS#: 151648-46-3

Description: NSC145021 is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-08-03. Prices are subject to change without notice.

NSC145021 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 597152
Name: NSC145021
CAS#: 151648-46-3
Chemical Formula: C20H20Cl2N8O5
Exact Mass: 522.0934
Molecular Weight: 523.33
Elemental Analysis: C, 45.90; H, 3.85; Cl, 13.55; N, 21.41; O, 15.29


Synonym: NSC145021; NSC 145021; NSC-145021;

IUPAC/Chemical Name: (2,5-dichloro-4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid

InChi Key: WGCHJFVQYMDTAB-LBPRGKRZSA-N

InChi Code: InChI=1S/C20H20Cl2N8O5/c1-30(7-8-6-25-17-15(26-8)16(23)28-20(24)29-17)13-5-10(21)9(4-11(13)22)18(33)27-12(19(34)35)2-3-14(31)32/h4-6,12H,2-3,7H2,1H3,(H,27,33)(H,31,32)(H,34,35)(H4,23,24,25,28,29)/t12-/m0/s1

SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC(Cl)=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1Cl)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Kostina EV, Sinyakov AN, Ryabinin VA. A many probes-one spot hybridization oligonucleotide microarray. Anal Bioanal Chem. 2018 Jun 22. doi: 10.1007/s00216-018-1190-8. [Epub ahead of print] PubMed PMID: 29934850.

2: Marler TE. Axial and Radial Spatial Patterns of Non-Structural Carbohydrates in Cycas micronesica Stems. Plants (Basel). 2018 Jun 22;7(3). pii: E49. doi: 10.3390/plants7030049. PubMed PMID: 29932150.

3: Kim DE, Lee JM, Ahrberg CD, Shaker MR, Lee JH, Sun W, Chung BG. Micropillar-based microfluidic device to regulate neurite networks of uniform-sized neurospheres. Electrophoresis. 2018 Jun 22. doi: 10.1002/elps.201800119. [Epub ahead of print] PubMed PMID: 29931692.

4: Lu P, Lei S, Li W, Lu Y, Zheng J, Wang N, Xia Y, Lu H, Chen X, Liu Y, Zhang PB. Dexmedetomidine Protects Neural Stem Cells from Ketamine-Induced Injury. Cell Physiol Biochem. 2018 Jun 19;47(4):1377-1388. doi: 10.1159/000490823. [Epub ahead of print] PubMed PMID: 29929189.

5: Proskuryakova AA, Kulemzina AI, Perelman PL, Serdukova NA, Ryder OA, Graphodatsky AS. The Case of X and Y Localization of Nucleolus Organizer Regions (NORs) in Tragulus javanicus (Cetartiodactyla, Mammalia). Genes (Basel). 2018 Jun 20;9(6). pii: E312. doi: 10.3390/genes9060312. PubMed PMID: 29925822.

6: Rando HM, Farré M, Robson MP, Won NB, Johnson JL, Buch R, Bastounes ER, Xiang X, Feng S, Liu S, Xiong Z, Kim J, Zhang G, Trut LN, Larkin DM, Kukekova AV. Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly. Genes (Basel). 2018 Jun 20;9(6). pii: E308. doi: 10.3390/genes9060308. PubMed PMID: 29925783.

7: Kim BE, Choi SW, Shin JH, Kim JJ, Kang I, Lee BC, Lee JY, Kook MG, Kang KS. Single-Factor SOX2 Mediates Direct Neural Reprogramming of Human Mesenchymal Stem Cells via Transfection of In Vitro Transcribed mRNA. Cell Transplant. 2018 Jan 1:963689718771885. doi: 10.1177/0963689718771885. [Epub ahead of print] PubMed PMID: 29909688.

8: Ding X, Yang W, Liu XD, Yang X, Wang HM, Tai J. Spinal SHP2 Contributes to Exaggerated Incisional Pain in Adult Rats Subjected to Neonatal and Adult Incisions via PI3K. Neuroscience. 2018 Jun 15. pii: S0306-4522(18)30424-X. doi: 10.1016/j.neuroscience.2018.06.013. [Epub ahead of print] PubMed PMID: 29909075.

9: Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Atzeni M, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barschel C, Barsuk S, Barter W, Baryshnikov F, Batozskaya V, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjørn M, Blake T, Blanc F, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bordyuzhin I, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Brodzicka J, Brundu D, Buchanan E, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, D'Ambrosio C, Da Cunha Marinho F, Da Silva CL, Dall'Occo E, Dalseno J, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Del Buono L, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Di Nezza P, Dijkstra H, Dordei F, Dorigo M, Dosil Suárez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fazzini D, Federici L, Ferguson D, Fernandez G, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Färber C, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, García Pardiñas J, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Gianì S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Graugés E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Grünberg O, Gushchin E, Guz Y, Gys T, Göbel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harnew ST, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Heß M, Hicheur A, Hill D, Hopchev PH, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Ibis P, Idzik M, Ilten P, Jacobsson R, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kim KE, Kirn T, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kosmyntseva A, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Krokovny P, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Leflat A, Lefrançois J, Lefèvre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li PR, Li T, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meier F, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Mogini A, Molina Rodriguez J, Mombächer T, Monroy IA, Monteil S, Morandin M, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Müller D, Müller J, Müller K, Müller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Nogay A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Ossowska A, Otalora Goicochea JM, Owen P, Oyanguren A, Pais PR, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pietrzyk G, Pikies M, Pinci D, Pisani F, Pistone A, Piucci A, Placinta V, Playfer S, Plo Casasus M, Polci F, Poli Lener M, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Potterat C, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Ruiz Vidal J, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith IT, Smith J, Smith M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Swientek K, Syropoulos V, Szumlak T, Szymanski M, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vacca C, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Verlage TA, Vernet M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voß C, de Vries JA, Vázquez Sierra C, Waldi R, Walsh J, Wang J, Wang Y, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams M, Williams T, Wilson FF, Wimberley J, Winn M, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xie Y, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S; LHCb Collaboration. Evidence for the Rare Decay Σ^{+}→pμ^{+}μ^{-}. Phys Rev Lett. 2018 Jun 1;120(22):221803. doi: 10.1103/PhysRevLett.120.221803. PubMed PMID: 29906142.

10: Zhong J, Chen DQ, Hung PSP, Hayes DJ, Liang KE, Davis KD, Hodaie M. Multivariate Pattern Classification of Brain White Matter Connectivity Predicts Classic Trigeminal Neuralgia. Pain. 2018 Jun 13. doi: 10.1097/j.pain.0000000000001312. [Epub ahead of print] PubMed PMID: 29905649.

11: Wu X, Zhao X, Miao X. MicroRNA-374b promotes the proliferation and differentiation of neural stem cells through targeting Hes1. Biochem Biophys Res Commun. 2018 Jun 18. pii: S0006-291X(18)31356-1. doi: 10.1016/j.bbrc.2018.06.044. [Epub ahead of print] PubMed PMID: 29902458.

12: Pletto D, Capra S, Finardi A, Colciaghi F, Nobili P, Battaglia GS, Locatelli D, Cagnoli C. Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures. PLoS One. 2018 Jun 14;13(6):e0199105. doi: 10.1371/journal.pone.0199105. eCollection 2018. PubMed PMID: 29902268; PubMed Central PMCID: PMC6001960.

13: Das SK, Choupoo NS, Pradhan D, Saikia P, Monnet X. Diagnostic accuracy of inferior vena caval respiratory variation in detecting fluid unresponsiveness: A systematic review and meta-analysis. Eur J Anaesthesiol. 2018 Jun 12. doi: 10.1097/EJA.0000000000000841. [Epub ahead of print] PubMed PMID: 29901465.

14: Zounemat-Kermani M, Ramezani-Charmahineh A, Adamowski J, Kisi O. Investigating the management performance of disinfection analysis of water distribution networks using data mining approaches. Environ Monit Assess. 2018 Jun 13;190(7):397. doi: 10.1007/s10661-018-6769-1. PubMed PMID: 29900478.

15: Bruce A, Santorelli G, Wright J, Bradbury J, Barrett BT, Bloj M, Sheldon TA. Prevalence of, and risk factors for, presenting visual impairment: findings from a vision screening programme based on UK NSC guidance in a multi-ethnic population. Eye (Lond). 2018 Jun 13. doi: 10.1038/s41433-018-0146-8. [Epub ahead of print] PubMed PMID: 29899459.

16: Li W, Hartmann H, Adams HD, Zhang H, Jin C, Zhao C, Guan D, Wang A, Yuan F, Wu J. The sweet side of global change-dynamic responses of non-structural carbohydrates to drought, elevated CO2 and nitrogen fertilization in tree species. Tree Physiol. 2018 Jun 11. doi: 10.1093/treephys/tpy059. [Epub ahead of print] PubMed PMID: 29897549.

17: Boese AC, Le QE, Pham D, Hamblin MH, Lee JP. Neural stem cell therapy for subacute and chronic ischemic stroke. Stem Cell Res Ther. 2018 Jun 13;9(1):154. doi: 10.1186/s13287-018-0913-2. Review. PubMed PMID: 29895321.

18: Lloret F, Sapes G, Rosas T, Galiano L, Saura-Mas S, Sala A, Martínez-Vilalta J. Non-structural carbohydrate dynamics associated with drought-induced die-off in woody species of a shrubland community. Ann Bot. 2018 Jun 8;121(7):1383-1396. doi: 10.1093/aob/mcy039. PubMed PMID: 29893878.

19: Ould-Brahim F, Sarma SN, Syal C, Lu KJ, Seegobin M, Carter A, Jeffers MS, Doré C, Stanford W, Corbett D, Wang J. Metformin Preconditioning of Human induced Pluripotent Stem Cell-derived Neural Stem Cells Promotes Their Engraftment and Improves Post-Stroke Regeneration and Recovery. Stem Cells Dev. 2018 Jun 12. doi: 10.1089/scd.2018.0055. [Epub ahead of print] PubMed PMID: 29893190.

20: Kawai K, Ichikawa M, Masuyama T, Ishihara M, Kijima Y. Impact of out-stent plaque characteristics on vascular response after second generation drug-eluting stent implantation: iMAP-intravascular ultrasound and angioscopic study. Int J Cardiol Heart Vasc. 2018 May 25;19:83-87. doi: 10.1016/j.ijcha.2018.05.004. eCollection 2018 Jun. PubMed PMID: 29892708; PubMed Central PMCID: PMC5993171.