Aminobenzoic acid
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MedKoo CAT#: 591784

CAS#: 150-13-0

Description: Aminobenzoic acid, an aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.

Chemical Structure

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Aminobenzoic acid
CAS# 150-13-0
Instruction

Theoretical Analysis

MedKoo Cat#: 591784
Name: Aminobenzoic acid
CAS#: 150-13-0
Chemical Formula: C7H7NO2
Exact Mass: 137.05
Molecular Weight: 137.140
Elemental Analysis: C, 61.31; H, 5.15; N, 10.21; O, 23.33

Price and Availability

Size Price Availability Quantity
25g USD 200
100g USD 330
500g USD 530
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Synonym: Aminobenzoic acid

IUPAC/Chemical Name: 4-Aminobenzoic acid

InChi Key: ALYNCZNDIQEVRV-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10)

SMILES Code: O=C(O)C1=CC=C(N)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 137.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cox L, Guberg K, Young S, Nicholson S, Steer T, Prentice A, Page P. Validation of thes use of p-aminobenzoic acid to determine completeness of 24 h urine collections in surveys of diet and nutrition. Eur J Clin Nutr. 2018 Jun 5. doi: 10.1038/s41430-018-0195-x. [Epub ahead of print] PubMed PMID: 29872160.

2: Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. [(11)C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 May 8. doi: 10.1021/acsinfecdis.8b00061. [Epub ahead of print] PubMed PMID: 29712422.

3: Jeong YR, Kim SY, Park YS, Lee GM. Simple and Robust N-Glycan Analysis Based on Improved 2-Aminobenzoic Acid Labeling for Recombinant Therapeutic Glycoproteins. J Pharm Sci. 2018 Jul;107(7):1831-1841. doi: 10.1016/j.xphs.2018.03.013. Epub 2018 Mar 21. PubMed PMID: 29574229.

4: Abellán-Llobregat A, González-Gaitán C, Vidal L, Canals A, Morallón E. Portable electrochemical sensor based on 4-aminobenzoic acid-functionalized herringbone carbon nanotubes for the determination of ascorbic acid and uric acid in human fluids. Biosens Bioelectron. 2018 Jun 30;109:123-131. doi: 10.1016/j.bios.2018.02.047. Epub 2018 Feb 23. PubMed PMID: 29547773.

5: Xia H, Attygalle AB. Transformation of the gas-phase favored O-protomer of p-aminobenzoic acid to its unfavored N-protomer by ion activation in the presence of water vapor: An ion-mobility mass spectrometry study. J Mass Spectrom. 2018 Apr;53(4):353-360. doi: 10.1002/jms.4066. PubMed PMID: 29377420.

6: Gaines E, Di Tommaso D. Solvation and Aggregation of Meta-Aminobenzoic Acid in Water: Density Functional Theory and Molecular Dynamics Study. Pharmaceutics. 2018 Jan 23;10(1). pii: E12. doi: 10.3390/pharmaceutics10010012. PubMed PMID: 29360788; PubMed Central PMCID: PMC5874825.

7: Laborda P, Zhao Y, Ling J, Hou R, Liu F. Production of Antifungal p-Aminobenzoic Acid in Lysobacter antibioticus OH13. J Agric Food Chem. 2018 Jan 24;66(3):630-636. doi: 10.1021/acs.jafc.7b05084. Epub 2018 Jan 12. PubMed PMID: 29283262.

8: Al-Zaydi KM, Khalil HH, El-Faham A, Khattab SN. Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity. Chem Cent J. 2017 May 10;11(1):39. doi: 10.1186/s13065-017-0267-3. PubMed PMID: 29086830; PubMed Central PMCID: PMC5423881.

9: Gan HM, Lee YP, Austin CM. Nanopore Long-Read Guided Complete Genome Assembly of Hydrogenophaga intermedia, and Genomic Insights into 4-Aminobenzenesulfonate, p-Aminobenzoic Acid and Hydrogen Metabolism in the Genus Hydrogenophaga. Front Microbiol. 2017 Oct 4;8:1880. doi: 10.3389/fmicb.2017.01880. eCollection 2017. PubMed PMID: 29046667; PubMed Central PMCID: PMC5632844.

10: Patrick AL, Cismesia AP, Tesler LF, Polfer NC. Effects of ESI conditions on kinetic trapping of the solution-phase protonation isomer of p-aminobenzoic acid in the gas phase. Int J Mass Spectrom. 2017 Jul;418:148-155. doi: 10.1016/j.ijms.2016.09.022. Epub 2016 Oct 7. PubMed PMID: 28781574; PubMed Central PMCID: PMC5542407.

11: Qiu L, Tian K, Pan J, Jiang L, Yang H, Zhu X, Shen B, Duan Y, Huang Y. A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin. Tetrahedron. 2017 Feb 9;73(6):771-775. doi: 10.1016/j.tet.2016.12.059. Epub 2016 Dec 28. PubMed PMID: 28626267; PubMed Central PMCID: PMC5471356.

12: Imai T, Tanaka K, Yonemitsu T, Yakushiji Y, Ohura K. Elucidation of the Intestinal Absorption of para-Aminobenzoic Acid, a Marker for Dietary Intake. J Pharm Sci. 2017 Sep;106(9):2881-2888. doi: 10.1016/j.xphs.2017.04.070. Epub 2017 May 24. PubMed PMID: 28549908.

13: Cismesia AP, Nicholls GR, Polfer NC. Amine vs. carboxylic acid protonation in ortho-, meta-, and para-aminobenzoic acid: An IRMPD spectroscopy study. J Mol Spectrosc. 2017 Feb;332:79-85. doi: 10.1016/j.jms.2016.10.020. Epub 2016 Nov 1. PubMed PMID: 28439142; PubMed Central PMCID: PMC5400370.

14: Giraldo A, Montes R, Rodil R, Quintana JB, Vidal-Liñán L, Beiras R. Ecotoxicological Evaluation of the UV Filters Ethylhexyl Dimethyl p-Aminobenzoic Acid and Octocrylene Using Marine Organisms Isochrysis galbana, Mytilus galloprovincialis and Paracentrotus lividus. Arch Environ Contam Toxicol. 2017 May;72(4):606-611. doi: 10.1007/s00244-017-0399-4. Epub 2017 Apr 8. PubMed PMID: 28391487.

15: Paul A, Kalita S, Kalita S, Sukumar P, Mandal B. Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid containing α/β and α/γ Hybrid Peptidomimetics. Sci Rep. 2017 Jan 5;7:40095. doi: 10.1038/srep40095. PubMed PMID: 28054630; PubMed Central PMCID: PMC5214534.

16: Thiede JM, Kordus SL, Turman BJ, Buonomo JA, Aldrich CC, Minato Y, Baughn AD. Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates. Sci Rep. 2016 Dec 1;6:38083. doi: 10.1038/srep38083. PubMed PMID: 27905500; PubMed Central PMCID: PMC5131483.

17: Chai Q, Zhang S, Wang X, Yang H, Xie YF. Effect of bromide on the transformation and genotoxicity of octyl-dimethyl-p-aminobenzoic acid during chlorination. J Hazard Mater. 2017 Feb 15;324(Pt B):626-633. doi: 10.1016/j.jhazmat.2016.11.035. Epub 2016 Nov 15. PubMed PMID: 27887814.

18: Zhai P, Chen X, Dong W, Li H, Chovelon JM. Degradation of triclosan in the presence of p-aminobenzoic acid under simulated sunlight irradiation. Environ Sci Pollut Res Int. 2017 Jan;24(1):558-567. doi: 10.1007/s11356-016-7778-7. Epub 2016 Oct 13. PubMed PMID: 27734316.

19: Singaraju AB, Nguyen K, Jain A, Haware RV, Stevens LL. Aggregate Elasticity, Crystal Structure, and Tableting Performance for p-Aminobenzoic Acid and a Series of Its Benzoate Esters. Mol Pharm. 2016 Nov 7;13(11):3794-3806. Epub 2016 Oct 24. PubMed PMID: 27723351.

20: Seo J, Warnke S, Gewinner S, Schöllkopf W, Bowers MT, Pagel K, von Helden G. The impact of environment and resonance effects on the site of protonation of aminobenzoic acid derivatives. Phys Chem Chem Phys. 2016 Sep 14;18(36):25474-25482. PubMed PMID: 27722299.