SW IV-52

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563114

CAS#: 845745-37-1

Description: SW IV-52 is an XIAP-inhibitor. It acts as a second mitochondria-derived activator of caspases (SMAC) mimetic.

Chemical Structure

SW IV-52
CAS# 845745-37-1

Theoretical Analysis

MedKoo Cat#: 563114
Name: SW IV-52
CAS#: 845745-37-1
Chemical Formula: C25H39ClN4O3
Exact Mass: 478.2711
Molecular Weight: 479.06
Elemental Analysis: C, 62.68; H, 8.21; Cl, 7.40; N, 11.70; O, 10.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SW IV-52; SW IV 52; SW IV52; SWIV52; SW-IV-52;

IUPAC/Chemical Name: 1-[3,3-Dimethyl-2(S)-(2(S)-methylamino-propionylamino)-butyryl]-pyrrolidine-2(S)-carboxylic acid (1,2,3,4-tetrahydro-naphthalen-1(R)-yl)-amide Hydrochloride


InChi Code: InChI=1S/C25H38N4O3.ClH/c1-16(26-5)22(30)28-21(25(2,3)4)24(32)29-15-9-14-20(29)23(31)27-19-13-8-11-17-10-6-7-12-18(17)19;/h6-7,10,12,16,19-21,26H,8-9,11,13-15H2,1-5H3,(H,27,31)(H,28,30);1H/t16-,19+,20-,21+;/m0./s1

SMILES Code: O=C([C@H]1N(C([C@@H](NC([C@@H](NC)C)=O)C(C)(C)C)=O)CCC1)N[C@@H]2CCCC3=C2C=CC=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 479.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wang H, Wang R, Xu S, Lakshmana MK. Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains. Neurosci J. 2016;2016:4732837. doi: 10.1155/2016/4732837. Epub 2016 Jun 28. PubMed PMID: 27433468; PubMed Central PMCID: PMC4940567.

2: Hashim YM, Spitzer D, Vangveravong S, Hornick MC, Garg G, Hornick JR, Goedegebuure P, Mach RH, Hawkins WG. Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134. Mol Oncol. 2014 Jul;8(5):956-67. doi: 10.1016/j.molonc.2014.03.005. Epub 2014 Mar 26. PubMed PMID: 24731702; PubMed Central PMCID: PMC4082741.

3: Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D. Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer. Mol Cancer. 2014 Mar 7;13:50. doi: 10.1186/1476-4598-13-50. PubMed PMID: 24602489; PubMed Central PMCID: PMC4015918.