Nooglutil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597129

CAS#: 112193-35-8

Description: Nooglutil is a nootropic agent being studied at the Research Institute of Pharmacology, Russian Academy of Medical Sciences as a potential treatment for amnesia. In animal models, it has a variety of central nervous system effects.

Chemical Structure

img
Nooglutil
CAS# 112193-35-8
Instruction

Theoretical Analysis

MedKoo Cat#: 597129
Name: Nooglutil
CAS#: 112193-35-8
Chemical Formula: C11H12N2O6
Exact Mass: 268.07
Molecular Weight: 268.220
Elemental Analysis: C, 49.26; H, 4.51; N, 10.44; O, 35.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Nooglutil; ONK-10; N-5-(Hydroxynicotinoyl)-l-glutamic acid;

IUPAC/Chemical Name: (5-hydroxynicotinoyl)-L-glutamic acid

InChi Key: XFZGYOJFPGPYCS-QMMMGPOBSA-N

InChi Code: InChI=1S/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1

SMILES Code: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC(O)=CN=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 268.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Iasnetsov VV, Krylova IN. [The antiamnestic effect of nootropic substances in rats]. Eksp Klin Farmakol. 2013;76(11):3-6. Russian. PubMed PMID: 24555225.

2: Vasil'eva EV, Salimov RM, Kovalev GI. [Effects of nootropic drugs on behavior of BALB/c and C57BL/6 mice in the exploratory cross-maze test]. Eksp Klin Farmakol. 2012;75(7):3-7. Russian. PubMed PMID: 23025044.

3: Kiselev AV, Stovbun SV, Sergienko VI. [The influence of calcium N-(5-hydroxynicotinoyl)-L-glutamate on reproductive function, prenatal and postnatal development of rats]. Eksp Klin Farmakol. 2012;75(2):26-9. Russian. PubMed PMID: 22550856.

4: Firstova IuIu, Vasil'eva EV, Kovalev GI. [Studying specific effects of nootropic drugs on glutamate receptors in the rat brain]. Eksp Klin Farmakol. 2011;74(1):6-10. Russian. PubMed PMID: 21476267.

5: Firsov AA, Portnoĭ IuA, Dovzhenko SA, Kobrin MB, Kiselev AV, Stovbun SV, Dolgova GV, Pomerantseva TIa. [Pharmacokinetics of n-(5-oxynicotinoyl)-L-glutamic acid calcium salt upon bolus administration in rats and rabbits: interspecies extrapolation]. Eksp Klin Farmakol. 2010 Dec;73(12):31-5. Russian. PubMed PMID: 21395015.

6: Firstova IuIu, Dolotov OV, Kondrakhin eA, Dubynina EV, Grivennikov IA, Kovalev GI. [Effects of nootropic drugs on hippocampal and cortical BDNF levels in mice with different exploratory behavior efficacy]. Eksp Klin Farmakol. 2009 Nov-Dec;72(6):3-6. Russian. PubMed PMID: 20095391.

7: Garibova TL, Voronina TA, Litvinova SA, Grigor'ev VV, Bachurin SO. [Effect of nooglutyl on the behavior and memory of SAMP10 mice with genetically determined accelerated aging]. Eksp Klin Farmakol. 2007 Jul-Aug;70(4):3-6. Russian. PubMed PMID: 18078032.

8: Belozertsev FIu, Belozertsev IuA, Slobodeniuk TF, Iuntsev SV, Shabel'skaia VV. [Comparison of neuroprotective properties of nootropes, calcium channel blockers, and panangin]. Eksp Klin Farmakol. 2007 Sep-Oct;70(5):12-4. Russian. PubMed PMID: 18074799.

9: Povarova OV, Garibova TL, Kalenikova EI, Galaeva IP, Kraĭneva VA, Medvedev OS, Voronina TA. [Effect of phenyl-tert-butylnitrone, mexidol and nooglutil on the ischemic lesion zone and memory in rats following middle cerebral artery occlusion]. Eksp Klin Farmakol. 2004 Jan-Feb;67(1):3-6. Russian. PubMed PMID: 15079898.

10: Iasnetsov VV, Provornova NA. [A method for reproducing amnesia in mice by the complex extremal exposure]. Eksp Klin Farmakol. 2003 May-Jun;66(3):66-8. Russian. PubMed PMID: 12924240.

11: Garibova TL, Galaeva IP, Voronina TA, Kraĭneva VA, Kapitsa IG, Kirichenko SV, Makarenko AN, Mirzoian GR, Kuznetsova EA. [Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)]. Eksp Klin Farmakol. 2003 May-Jun;66(3):13-6. Russian. PubMed PMID: 12924225.

12: Voronina TA, Borlikova GG, Garibova TL, Proskuryakova TV, Petrichenko OB, Burd SG, Avakyan GN. Effect of nooglutil on benzodiazepine withdrawal syndrome and binding of 3H-spiperone with D2 receptors in rat striatum. Bull Exp Biol Med. 2002 Nov;134(5):448-50. PubMed PMID: 12802448.

13: Motin V, Yasnetsov V, Kovalev S, Krylova I. Effects of nootropics on electrical activity in rat hippocampal CA1 area. Bull Exp Biol Med. 2000 Sep;130(9):830-1. PubMed PMID: 11177255.

14: Voronina TA. [Hypoxia and memory. Specific features of nootropic agents effects and their use]. Vestn Ross Akad Med Nauk. 2000;(9):27-34. Review. Russian. PubMed PMID: 11055197.

15: Chesnokova EA, Sariev AK, Zherdev VP, Kartashov VS, Smirnov LD. [The bioavailability of tableted drug forms of the new Russian nootropic preparation nooglutil in rabbits]. Eksp Klin Farmakol. 1998 Jul-Aug;61(4):48-50. Russian. PubMed PMID: 9783110.

16: Novikov VE, Kovaleva LA. [The effect of substances with nootropic activity on oxidative phosphorylation in brain mitochondria in acute craniocerebral trauma]. Eksp Klin Farmakol. 1997 Jan-Feb;60(1):59-61. Russian. PubMed PMID: 9162289.

17: Iasnetsov VV, Krylova IN, Popov VM. [The nootropic correction of disorders in learning and memory processes induced by extreme exposures]. Eksp Klin Farmakol. 1996 May-Jun;59(3):20-3. Russian. PubMed PMID: 8974577.

18: Trofimov SS, Ostrovskaia RU, Smol'nikova NM, Nemova EP, Gudasheva TA, Kuznetsova EA, Voronina TA. [The correction with nooglutil and L-pyroglutamyl-D-alanine amide of cognitive disorders in rats due to intrauterine hypoxia]. Eksp Klin Farmakol. 1995 Nov-Dec;58(6):10-3. Russian. PubMed PMID: 8704601.

19: Iasentsov VV, Pravdivtsev VA, Popov VM, Voronina TP, Kiseleva NM, Kozlov SB. [Antimotion-sickness effect of nooglutil and its neuronal mechanism]. Biull Eksp Biol Med. 1995 May;119(5):515-6. Russian. PubMed PMID: 7579248.

20: Kovalev GI, Budygin EA, Gaĭnetdinov RR, Kudrin VS, Trofimov SS, Ostrovskaia RU. [The sodium oxybutyrate and nooglutil correction of dopamine release in the striatum of prenatally alcoholized rat pups]. Biull Eksp Biol Med. 1993 Jul;116(7):56-8. Russian. PubMed PMID: 8400184.