WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563112

CAS#: 1421931-14-7

Description: SW120 is a fluorescent sigma-2 selective ligand.

Chemical Structure

CAS# 1421931-14-7

Theoretical Analysis

MedKoo Cat#: 563112
Name: SW120
CAS#: 1421931-14-7
Chemical Formula: C33H48N6O7
Exact Mass: 640.3584
Molecular Weight: 640.78
Elemental Analysis: C, 61.86; H, 7.55; N, 13.12; O, 17.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: SW120; SW-120; SW 120;

IUPAC/Chemical Name: (2,5-Dimethoxy-phenyl)-carbamic acid 9-[10-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-decyl]-9-aza-bicyclo[3.3.1]non-3-yl ester


InChi Code: InChI=1S/C33H48N6O7/c1-43-26-14-16-31(44-2)29(22-26)36-33(40)45-27-20-24-12-11-13-25(21-27)37(24)19-10-8-6-4-3-5-7-9-18-34-28-15-17-32(39(41)42)38-30(28)23-35-46-38/h14-17,22-25,27,34-35H,3-13,18-21H2,1-2H3,(H,36,40)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 640.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bean DC, Wigmore SM, Wareham DW. Draft Genome Sequence of Staphylococcus cohnii subsp. urealyticus Isolated from a Healthy Dog. Genome Announc. 2017 Feb 16;5(7). pii: e01628-16. doi: 10.1128/genomeA.01628-16. PubMed PMID: 28209829; PubMed Central PMCID: PMC5313621.

2: Zeng C, Garg N, Mach RH. The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells. Mol Imaging Biol. 2016 Apr;18(2):172-9. doi: 10.1007/s11307-015-0891-z. PubMed PMID: 26335282.

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5: Haller JL, Panyutin I, Chaudhry A, Zeng C, Mach RH, Frank JA. Sigma-2 receptor as potential indicator of stem cell differentiation. Mol Imaging Biol. 2012 Jun;14(3):325-35. doi: 10.1007/s11307-011-0493-3. PubMed PMID: 21614680; PubMed Central PMCID: PMC3164741.

6: Törnsten A, Jeon JT, Alexander LJ, Andersson L, Chowdhary BP. Physical ordering of six YACs from the RN region in pigs. Anim Genet. 1998 Aug;29(4):319-21. PubMed PMID: 9745672.

7: Reinsch N, Looft C, Rudat I, Kalm E. The Kiel RN experiment: final porcine chromosome 15 mapping results. J Anim Breed Genet. 1997 Jan 12;114(1-6):133-42. doi: 10.1111/j.1439-0388.1997.tb00500.x. PubMed PMID: 21395810.

8: Milan D, Woloszyn N, Yerle M, Le Roy P, Bonnet M, Riquet J, Lahbib-Mansais Y, Caritez JC, Robic A, Sellier P, Elsen JM, Gellin J. Accurate mapping of the "acid meat" RN gene on genetic and physical maps of pig chromosome 15. Mamm Genome. 1996 Jan;7(1):47-51. PubMed PMID: 8903728.