WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597126
Description: alpha-Glutamylthymine is a hypermodified base in DNA.
MedKoo Cat#: 597126
Chemical Formula: C10H13N3O6
Exact Mass: 271.0804
Molecular Weight: 271.22
Elemental Analysis: C, 44.28; H, 4.83; N, 15.49; O, 35.39
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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IUPAC/Chemical Name: ((2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl)-L-glutamic acid
InChi Key: XHGJNVZDOQDSDY-LURJTMIESA-N
InChi Code: InChI=1S/C10H13N3O6/c14-7(15)2-1-6(9(17)18)11-3-5-4-12-10(19)13-8(5)16/h4,6,11H,1-3H2,(H,14,15)(H,17,18)(H2,12,13,16,19)/t6-/m0/s1
SMILES Code: O=C(O)CC[C@@H](C(O)=O)NCC1=CNC(NC1=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 271.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Iyer LM, Zhang D, Burroughs AM, Aravind L. Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA. Nucleic Acids Res. 2013 Sep;41(16):7635-55. doi: 10.1093/nar/gkt573. Epub 2013 Jun 28. PubMed PMID: 23814188; PubMed Central PMCID: PMC3763556.
2: Warren RA. Modified bases in bacteriophage DNAs. Annu Rev Microbiol. 1980;34:137-58. Review. PubMed PMID: 7002022.