Acetyleugenol | CAS#93-28-7 | anticancer

Acetyleugenol
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591749

CAS#: 93-28-7

Description: Acetyleugenol is known to reduce cell proliferation and delayed the cell cycle.

Chemical Structure

Acetyleugenol

CAS# 93-28-7

Instruction

Theoretical Analysis

MedKoo Cat#: 591749
Name: Acetyleugenol
CAS#: 93-28-7
Chemical Formula: C12H14O3
Exact Mass: 206.09
Molecular Weight: 206.240
Elemental Analysis: C, 69.89; H, 6.84; O, 23.27

Price and Availability

Size	Price	Availability	Quantity
25g	USD 250	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Acetyleugenol; NSC 1242; NSC-1242; NSC1242; Eugenol Acetate.

IUPAC/Chemical Name: 4-Allyl-2-methoxyphenyl acetate

InChi Key: SCCDQYPEOIRVGX-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14O3/c1-4-5-10-6-7-11(15-9(2)13)12(8-10)14-3/h4,6-8H,1,5H2,2-3H3

SMILES Code: CC(OC1=CC=C(CC=C)C=C1OC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 206.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Saha S, Verma RJ. Molecular interactions of active constituents of essential oils in zwitterionic lipid bilayers. Chem Phys Lipids. 2018 Jul;213:76-87. doi: 10.1016/j.chemphyslip.2018.03.008. Epub 2018 Mar 27. PubMed PMID: 29596800.

2: Drewes CC, Alves AC, Hebeda CB, Copetti I, Sandri S, Uchiyama MK, Araki K, Guterres SS, Pohlmann AR, Farsky SH. Role of poly(ε-caprolactone) lipid-core nanocapsules on melanoma-neutrophil crosstalk. Int J Nanomedicine. 2017 Sep 27;12:7153-7163. doi: 10.2147/IJN.S140557. eCollection 2017. PubMed PMID: 29026308; PubMed Central PMCID: PMC5627757.

3: Musthafa KS, Hmoteh J, Thamjarungwong B, Voravuthikunchai SP. Antifungal potential of eugenyl acetate against clinical isolates of Candida species. Microb Pathog. 2016 Oct;99:19-29. doi: 10.1016/j.micpath.2016.07.012. Epub 2016 Jul 22. PubMed PMID: 27452957.

4: Cansian RL, Vanin AB, Orlando T, Piazza SP, Puton BM, Cardoso RI, Gonçalves IL, Honaiser TC, Paroul N, Oliveira D. Toxicity of clove essential oil and its ester eugenyl acetate against Artemia salina. Braz J Biol. 2017 Mar;77(1):155-161. doi: 10.1590/1519-6984.12215. Epub 2016 Jul 4. PubMed PMID: 27382998.

5: Drewes CC, Fiel LA, Bexiga CG, Asbahr AC, Uchiyama MK, Cogliati B, Araki K, Guterres SS, Pohlmann AR, Farsky SP. Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models. Int J Nanomedicine. 2016 Mar 31;11:1261-79. doi: 10.2147/IJN.S101543. eCollection 2016. PubMed PMID: 27099491; PubMed Central PMCID: PMC4821388.

6: Silva MJ, Loss RA, Laroque DA, Lerin LA, Pereira GN, Thon É, Oliveira JV, Ninow JL, Hense H, Oliveira D. Lipozyme TL IM as Catalyst for the Synthesis of Eugenyl Acetate in Solvent-Free Acetylation. Appl Biochem Biotechnol. 2015 Jun;176(3):782-95. doi: 10.1007/s12010-015-1611-5. Epub 2015 Apr 15. PubMed PMID: 25875787.

7: Pasay C, Mounsey K, Stevenson G, Davis R, Arlian L, Morgan M, Vyszenski-Moher D, Andrews K, McCarthy J. Acaricidal activity of eugenol based compounds against scabies mites. PLoS One. 2010 Aug 11;5(8):e12079. doi: 10.1371/journal.pone.0012079. PubMed PMID: 20711455; PubMed Central PMCID: PMC2920318.

8: Prakash B, Shukla R, Singh P, Kumar A, Mishra PK, Dubey NK. Efficacy of chemically characterized Piper betle L. essential oil against fungal and aflatoxin contamination of some edible commodities and its antioxidant activity. Int J Food Microbiol. 2010 Aug 15;142(1-2):114-9. doi: 10.1016/j.ijfoodmicro.2010.06.011. Epub 2010 Jun 19. PubMed PMID: 20621374.

9: Shen Q, Li W, Li W. The effect of clove oil on the transdermal delivery of ibuprofen in the rabbit by in vitro and in vivo methods. Drug Dev Ind Pharm. 2007 Dec;33(12):1369-74. PubMed PMID: 18097811.

10: Yang YC, Lee SH, Lee WJ, Choi DH, Ahn YJ. Ovicidal and adulticidal effects of Eugenia caryophyllata bud and leaf oil compounds on Pediculus capitis. J Agric Food Chem. 2003 Aug 13;51(17):4884-8. PubMed PMID: 12903940.

11: Kim EH, Kim HK, Ahn YJ. Acaricidal activity of clove bud oil compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). J Agric Food Chem. 2003 Feb 12;51(4):885-9. PubMed PMID: 12568544.

12: Srivastava KC. Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]. Prostaglandins Leukot Essent Fatty Acids. 1993 May;48(5):363-72. Erratum in: Prostaglandins Leukot Essent Fatty Acids 1993 Nov;49(5):885. PubMed PMID: 8321872.

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