N-Acetylpurinomycin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563094

CAS#: 22852-13-7

Description: N-Acetylpurinomycin is a selective CB2 receptor agonist.


Price and Availability

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N-Acetylpurinomycin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563094
Name: N-Acetylpurinomycin
CAS#: 22852-13-7
Chemical Formula: C24H31N7O6
Exact Mass: 513.2336
Molecular Weight: 513.55
Elemental Analysis: C, 56.13; H, 6.08; N, 19.09; O, 18.69


Synonym: N-Acetylpurinomycin; N Acetylpurinomycin;

IUPAC/Chemical Name: 3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine

InChi Key: LADKVYSQIGJMFP-IYRMOJGWSA-N

InChi Code: InChI=1S/C24H31N7O6/c1-13(33)28-16(9-14-5-7-15(36-4)8-6-14)23(35)29-18-17(10-32)37-24(20(18)34)31-12-27-19-21(30(2)3)25-11-26-22(19)31/h5-8,11-12,16-18,20,24,32,34H,9-10H2,1-4H3,(H,28,33)(H,29,35)/t16-,17+,18+,20+,24+/m0/s1

SMILES Code: OC[C@@H]1[C@@H](NC([C@@H](NC(C)=O)CC2=CC=C(OC)C=C2)=O)[C@H]([C@H](N3C=NC4=C(N=CN=C43)N(C)C)O1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Tercero JA, Espinosa JC, Jiménez A. Expression of the Streptomyces alboniger pur cluster in Streptomyces lividans is dependent on the bldA-encoded tRNALeu. FEBS Lett. 1998 Jan 16;421(3):221-3. PubMed PMID: 9468310.

2: Tercero JA, Espinosa JC, Lacalle RA, Jiménez A. The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger. J Biol Chem. 1996 Jan 19;271(3):1579-90. PubMed PMID: 8576156.

3: Tercero JA, Lacalle RA, Jimenez A. The pur8 gene from the pur cluster of Streptomyces alboniger encodes a highly hydrophobic polypeptide which confers resistance to puromycin. Eur J Biochem. 1993 Dec 15;218(3):963-71. PubMed PMID: 7916693.

4: Lacalle RA, Tercero JA, Vara J, Jimenez A. Identification of the gene encoding an N-acetylpuromycin N-acetylhydrolase in the puromycin biosynthetic gene cluster from Streptomyces alboniger. J Bacteriol. 1993 Nov;175(22):7474-8. PubMed PMID: 8226694; PubMed Central PMCID: PMC206894.

5: Lacalle RA, Tercero JA, Jiménez A. Cloning of the complete biosynthetic gene cluster for an aminonucleoside antibiotic, puromycin, and its regulated expression in heterologous hosts. EMBO J. 1992 Feb;11(2):785-92. PubMed PMID: 1537349; PubMed Central PMCID: PMC556512.

6: Vara J, Perez-Gonzalez JA, Jimenez A. Biosynthesis of puromycin by Streptomyces alboniger: characterization of puromycin N-acetyltransferase. Biochemistry. 1985 Dec 31;24(27):8074-81. PubMed PMID: 4092057.