MedKoo Biosciences

A22 hydrochloride
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555259

CAS#: 22816-60-0 (HCl)

Description: A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport.

Chemical Structure

A22 hydrochloride

CAS# 22816-60-0 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 555259
Name: A22 hydrochloride
CAS#: 22816-60-0 (HCl)
Chemical Formula: C8H9Cl3N2S
Exact Mass: 0.00
Molecular Weight: 271.584
Elemental Analysis: C, 35.38; H, 3.34; Cl, 39.16; N, 10.32; S, 11.80

Price and Availability

Size	Price	Availability
10mg	USD 390	2 Weeks
25mg	USD 610	2 Weeks
50mg	USD 820	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 22816-60-0 (HCl) 22297-13-8 (free base)

Synonym: MreB Perturbing Compound A22; A22 hydrochloride.

IUPAC/Chemical Name: S-(3,4-Dichlorobenzyl)isothiourea hydrochloride

InChi Key: VBJNMXMOMSWRDV-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H

SMILES Code: N=C(N)SCC1=CC=C(Cl)C(Cl)=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 271.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bonez PC, Rossi GG, Bandeira JR, Ramos AP, Mizdal CR, Agertt VA, Dalla Nora
ESS, de Souza ME, Dos Santos Alves CF, Dos Santos FS, Gündel A, de Almeida
Vaucher R, Santos RCV, de Campos MMA. Anti-biofilm activity of A22
((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas
aeruginosa: Influence on biofilm formation, motility and bioadhesion. Microb
Pathog. 2017 Oct;111:6-13. doi: 10.1016/j.micpath.2017.08.008. Epub 2017 Aug 10.
PubMed PMID: 28804018.

2: Bonez PC, Ramos AP, Nascimento K, Copetti PM, Souza ME, Rossi GG, Agertt VA,
Sagrillo MR, Santos RC, Campos MM. Antibacterial, cyto and genotoxic activities
of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride). Microb
Pathog. 2016 Oct;99:14-18. doi: 10.1016/j.micpath.2016.07.007. Epub 2016 Jul 16.
PubMed PMID: 27427089.

3: Nicholson A, Perry JD, James AL, Stanforth SP, Carnell S, Wilkinson K, Anjam
Khan CM, De Soyza A, Gould FK. In vitro activity of
S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related
compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa
and Burkholderia cepacia complex. Int J Antimicrob Agents. 2012 Jan;39(1):27-32.
doi: 10.1016/j.ijantimicag.2011.08.015. Epub 2011 Oct 10. PubMed PMID: 21993484.

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