WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555259
CAS#: 22816-60-0 (HCl)
Description: A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport.
MedKoo Cat#: 555259
Name: A22 hydrochloride
CAS#: 22816-60-0 (HCl)
Chemical Formula: C8H9Cl3N2S
Exact Mass:
Molecular Weight: 271.584
Elemental Analysis: C, 35.38; H, 3.34; Cl, 39.16; N, 10.32; S, 11.80
Related CAS #: 22816-60-0 (HCl)
Synonym: MreB Perturbing Compound A22; A22 hydrochloride.
IUPAC/Chemical Name: S-(3,4-Dichlorobenzyl)isothiourea hydrochloride
InChi Key: VBJNMXMOMSWRDV-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(3-7(6)10)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
SMILES Code: N=C(N)SCC1=CC=C(Cl)C(Cl)=C1.[H]Cl
1: Bonez PC, Rossi GG, Bandeira JR, Ramos AP, Mizdal CR, Agertt VA, Dalla Nora
ESS, de Souza ME, Dos Santos Alves CF, Dos Santos FS, Gündel A, de Almeida
Vaucher R, Santos RCV, de Campos MMA. Anti-biofilm activity of A22
((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas
aeruginosa: Influence on biofilm formation, motility and bioadhesion. Microb
Pathog. 2017 Oct;111:6-13. doi: 10.1016/j.micpath.2017.08.008. Epub 2017 Aug 10.
PubMed PMID: 28804018.
2: Bonez PC, Ramos AP, Nascimento K, Copetti PM, Souza ME, Rossi GG, Agertt VA,
Sagrillo MR, Santos RC, Campos MM. Antibacterial, cyto and genotoxic activities
of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride). Microb
Pathog. 2016 Oct;99:14-18. doi: 10.1016/j.micpath.2016.07.007. Epub 2016 Jul 16.
PubMed PMID: 27427089.
3: Nicholson A, Perry JD, James AL, Stanforth SP, Carnell S, Wilkinson K, Anjam
Khan CM, De Soyza A, Gould FK. In vitro activity of
S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related
compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa
and Burkholderia cepacia complex. Int J Antimicrob Agents. 2012 Jan;39(1):27-32.
doi: 10.1016/j.ijantimicag.2011.08.015. Epub 2011 Oct 10. PubMed PMID: 21993484.