N-Butyl stearate
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591636

CAS#: 123-95-5

Description: Butyl stearate enteric-coated tablets cause a reaction in intestinal enzymes.


Chemical Structure

img
N-Butyl stearate
CAS# 123-95-5

Theoretical Analysis

MedKoo Cat#: 591636
Name: N-Butyl stearate
CAS#: 123-95-5
Chemical Formula: C22H44O2
Exact Mass: 340.33
Molecular Weight: 340.592
Elemental Analysis: C, 77.58; H, 13.02; O, 9.39

Price and Availability

Size Price Availability Quantity
25g USD 210
400g USD 370
Bulk inquiry

Synonym: N-Butyl stearate; NSC 4820 NSC-4820; NSC4820

IUPAC/Chemical Name: Octadecanoic acid, butyl ester

InChi Key: ULBTUVJTXULMLP-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H44O2/c1-3-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22(23)24-21-6-4-2/h3-21H2,1-2H3

SMILES Code: CCCCCCCCCCCCCCCCCC(OCCCC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Butyl stearate enteric-coated tablets cause a reaction in intestinal enzymes.
In vitro activity: Comparative analysis of the thermographs shown in Figure 1 indicated, as expected, that the sample of pure butyl stearate has the best heat storage properties. From the TGA analysis, it was observed that the mass loss is much higher and at a much lower temperature in the case of the butyl stearate sample. The butyl stearate microcapsules encapsulated in a PMMA membrane had a fairly uniform particle size distribution. Also, the co-preservation process was an appropriate one in that the PMMA layer was relatively uniform in thickness, and this was observed after electron microscopy analysis (Figure 10). Reference: Polymers (Basel). 2020 Feb 18;12(2):467. https://pubmed.ncbi.nlm.nih.gov/32085434/
In vivo activity: In vivo pharmacokinetic study was conducted on female beagle dogs. Spherical microspheres with smooth surfaces, small internal pores and shell structures were initially prepared. It was found that 3% (w/w) butyl stearate prolonged the in vitro drug release period from 46 to 82 days, and in vivo release period from 20 to 27 days. Reference: Mol Med Rep. 2019 Mar;19(3):1595-1602. https://pubmed.ncbi.nlm.nih.gov/30592277/

Preparing Stock Solutions

The following data is based on the product molecular weight 340.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Bendic V, Dobrotă D, Simion I, Bălan E, Pascu NE, Tilina DI. Methods for Determining the Thermal Transfer in Phase-Changing Materials (PCMs). Polymers (Basel). 2020 Feb 18;12(2):467. doi: 10.3390/polym12020467. PMID: 32085434; PMCID: PMC7077708. 2. Marske F, Martins de Souza E Silva J, Wehrspohn RB, Hahn T, Enke D. Synthesis of monolithic shape-stabilized phase change materials with high mechanical stability via a porogen-assisted in situ sol-gel process. RSC Adv. 2020 Jan 16;10(6):3072-3083. doi: 10.1039/c9ra10631f. PMID: 35497767; PMCID: PMC9048775. 3. Sun F, Yu C, Liu X, Wang D, Liu N, Liu J, Teng L, Li Y. Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation. Mol Med Rep. 2019 Mar;19(3):1595-1602. doi: 10.3892/mmr.2018.9797. Epub 2018 Dec 24. PMID: 30592277; PMCID: PMC6390036.
In vitro protocol: 1. Bendic V, Dobrotă D, Simion I, Bălan E, Pascu NE, Tilina DI. Methods for Determining the Thermal Transfer in Phase-Changing Materials (PCMs). Polymers (Basel). 2020 Feb 18;12(2):467. doi: 10.3390/polym12020467. PMID: 32085434; PMCID: PMC7077708. 2. Marske F, Martins de Souza E Silva J, Wehrspohn RB, Hahn T, Enke D. Synthesis of monolithic shape-stabilized phase change materials with high mechanical stability via a porogen-assisted in situ sol-gel process. RSC Adv. 2020 Jan 16;10(6):3072-3083. doi: 10.1039/c9ra10631f. PMID: 35497767; PMCID: PMC9048775.
In vivo protocol: 1. Sun F, Yu C, Liu X, Wang D, Liu N, Liu J, Teng L, Li Y. Butyl stearate prolongs the drug release period of isoperidone‑loaded poly (lactic‑co‑glycolic acid) microspheres: In vitro and in vivo investigation. Mol Med Rep. 2019 Mar;19(3):1595-1602. doi: 10.3892/mmr.2018.9797. Epub 2018 Dec 24. PMID: 30592277; PMCID: PMC6390036.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Carr AL, Sonenshine DE, Strider JB Jr, Roe RM. Evidence of female sex pheromones and characterization of the cuticular lipids of unfed, adult male versus female blacklegged ticks, Ixodes scapularis. Exp Appl Acarol. 2016 Apr;68(4):519-38. doi: 10.1007/s10493-015-0009-y. Epub 2016 Feb 10. PubMed PMID: 26864785; PubMed Central PMCID: PMC4785100.

2: Tshilanda DD, Mpiana PT, Onyamboko DN, Mbala BM, Ngbolua KT, Tshibangu DS, Bokolo MK, Taba KM, Kasonga TK. Antisickling activity of butyl stearate isolated from Ocimum basilicum (Lamiaceae). Asian Pac J Trop Biomed. 2014 May;4(5):393-8. doi: 10.12980/APJTB.4.2014C1329. PubMed PMID: 25182725; PubMed Central PMCID: PMC3985055.

3: Gołębiowski M, Cerkowniak M, Urbanek A, Dawgul M, Kamysz W, Boguś MI, Stepnowski P. Identification and antifungal activity of novel organic compounds found in cuticular and internal lipids of medically important flies. Microbiol Res. 2015 Jan;170:213-22. doi: 10.1016/j.micres.2014.06.004. Epub 2014 Jun 26. PubMed PMID: 25026883.

4: Ma Y, Chu X, Tang G, Yao Y. The effect of different soft segments on the formation and properties of binary core microencapsulated phase change materials with polyurea/polyurethane double shell. J Colloid Interface Sci. 2013 Feb 15;392:407-414. doi: 10.1016/j.jcis.2012.10.052. Epub 2012 Nov 8. PubMed PMID: 23201062.

5: Nguyen SH, Dang TP, Maibach HI. Comedogenicity in rabbit: some cosmetic ingredients/vehicles. Cutan Ocul Toxicol. 2007;26(4):287-92. PubMed PMID: 18058303.

6: Correa MA, Scarpa MV, Franzini MC, Oliveira AG. On the incorporation of the non-steroidal anti-inflammatory naproxen into cationic O/W microemulsions. Colloids Surf B Biointerfaces. 2005 Jun 25;43(2):108-14. PubMed PMID: 15919187.

7: Kuo SC. A simple assay for local heating by optical tweezers. Methods Cell Biol. 1998;55:43-5. PubMed PMID: 9352510.

8: Bieber WD, Freytag W, Figge K, vom Bruck CG, Rossi L. Transfer of additives from plastics materials into foodstuffs and into food simulants--a comparison. Food Chem Toxicol. 1984 Sep;22(9):737-42. PubMed PMID: 6541627.

9: Fulton JE Jr, Pay SR, Fulton JE 3rd. Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear. J Am Acad Dermatol. 1984 Jan;10(1):96-105. PubMed PMID: 6229554.

10: Bomford R. The adjuvant activity of fatty acid esters. The role of acyl chain length and degree of saturation. Immunology. 1981 Sep;44(1):187-92. PubMed PMID: 7275184; PubMed Central PMCID: PMC1555125.

11: SMITH CC. Toxicity of butyl stearate, dibutyl sebacate, dibutyl phthalate, and methoxyethyl oleate. AMA Arch Ind Hyg Occup Med. 1953 Apr;7(4):310-8. PubMed PMID: 13039587.

12: BAUER CW, MASUCCI PE. The action of intestinal enzymes upon cellulose acetate phthalate and butyl stearate enteric-coated tablets. J Am Pharm Assoc Am Pharm Assoc. 1948 Mar;37(3):124-8. PubMed PMID: 18905813.

13: BRADLEY RS, EVANS MG, WHYTLAWGRAY RW. The rate of evaporation of droplets; evaporation and diffusion coefficients, and vapour pressures of dibutyl phthalate and butyl stearate. Proc R Soc Lond A Math Phys Sci. 1946;186(1006):368-90. PubMed PMID: 20998740.