Paclitaxel Poliglumex

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597118

CAS#: 263351-82-2 (Poliglumex)

Description: Paclitaxel Poliglumex is a bioconjugate in which paclitaxel is linked to a biodegradable, water-soluble polyglutamate polymer with antineoplastic properties. The polyglutamate residue increases the water solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone. Paclitaxel promotes microtubule assembly and prevents microtubule depolymerization, thus interfering with normal mitosis.

Chemical Structure

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Paclitaxel Poliglumex
CAS# 263351-82-2 (Poliglumex)
Instruction

Theoretical Analysis

MedKoo Cat#: 597118
Name: Paclitaxel Poliglumex
CAS#: 263351-82-2 (Poliglumex)
Chemical Formula: C52H60N2O18
Exact Mass: 0.00
Molecular Weight: 1,001.040
Elemental Analysis: C, 62.39; H, 6.04; N, 2.80; O, 28.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 186040-50-6 (ceribate)   33069-62-4 (free base)   263351-82-2 (Poliglumex)   Paclitaxel-SMCC   117527-50-1 (Paclitaxel-Succinic acid)   Paclitaxel-MVCP  

Synonym: Paclitaxel Poliglumex; PG-TXL; PPX; CT 2103; CT-2103; CT2103; Opaxio; Xyotax; paclitaxel-polyglutamate polymer; polyglutamate paclitaxel; polyglutamic acid paclitaxel; Poly-L-Glutamic acid-Paclitaxel Conjugate;

IUPAC/Chemical Name: (2aS,4S,4aS,6R,9S,11R,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate L-glutamate

InChi Key: ZPUHVPYXSITYDI-ZYOSQDPASA-N

InChi Code: InChI=1S/C47H51NO14.C5H9NO4/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5;6-3(5(9)10)1-2-4(7)8/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54);3H,1-2,6H2,(H,7,8)(H,9,10)/t31-,32-,33-,35-,36+,37+,38-,40-,45+,46-,47-;3-/m00/s1

SMILES Code: CC([C@@H](OC([C@H](O)[C@@H](NC(c1ccccc1)=O)c2ccccc2)=O)C3)=C([C@H]4OC(C)=O)C(C)(C)[C@@]3(O)[C@@H](OC(c5ccccc5)=O)[C@@H]6[C@]7(OC(C)=O)CO[C@H]7C[C@H](O)[C@@]6(C)C4=O.O=C(O)[C@@H](N)CCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,001.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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