Calcium diglutamate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597111

CAS#: 5996-22-5

Description: Calcium diglutamate, sometimes abbreviated CDG is a calcium acid salt of glutamic acid. CDG is a flavor enhancer (E number E623) — it is the calcium analog of monosodium glutamate (MSG). Because the glutamate is the actual flavor-enahancer, CDG has the same flavor-enhancing properties as MSG, but without the increased sodium content. As a soluble source of calcium ions, this chemical is also used as a first-aid treatment for exposure to hydrofluoric acid.

Chemical Structure

Calcium diglutamate
CAS# 5996-22-5

Theoretical Analysis

MedKoo Cat#: 597111
Name: Calcium diglutamate
CAS#: 5996-22-5
Chemical Formula: C10H16CaN2O8
Exact Mass:
Molecular Weight: 332.32
Elemental Analysis: C, 36.14; H, 4.85; Ca, 12.06; N, 8.43; O, 38.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Calcium diglutamate; Calcium di-L-glutamate; Glutamic acid, calcium salt (2:1), L-;

IUPAC/Chemical Name: calcium (S)-2-amino-4-carboxybutanoate


InChi Code: InChI=1S/2C5H9NO4.Ca/c2*6-3(5(9)10)1-2-4(7)8;/h2*3H,1-2,6H2,(H,7,8)(H,9,10);/q;;+2/p-2/t2*3-;/m00./s1

SMILES Code: N[C@@H](CCC(O)=O)C([O-])=O.N[C@@H](CCC(O)=O)C([O-])=O.[Ca+2]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 332.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bain JL, Culpepper BK, Reddy MS, Bellis SL. Comparing variable-length polyglutamate domains to anchor an osteoinductive collagen-mimetic peptide to diverse bone grafting materials. Int J Oral Maxillofac Implants. 2014 Nov-Dec;29(6):1437-45. doi: 10.11607/jomi.3759. PubMed PMID: 25397807; PubMed Central PMCID: PMC4504020.

2: Türkoğlu Ş. Evaluation of genotoxic effects of five flavour enhancers (glutamates) on the root meristem cells of Allium cepa. Toxicol Ind Health. 2015 Sep;31(9):792-801. doi: 10.1177/0748233713475509. Epub 2013 Feb 1. PubMed PMID: 23377115.

3: Ball P, Woodward D, Beard T, Shoobridge A, Ferrier M. Calcium diglutamate improves taste characteristics of lower-salt soup. Eur J Clin Nutr. 2002 Jun;56(6):519-23. PubMed PMID: 12032651.

4: Schiffman SS, Frey AE, Luboski JA, Foster MA, Erickson RP. Taste of glutamate salts in young and elderly subjects: role of inosine 5'-monophosphate and ions. Physiol Behav. 1991 May;49(5):843-54. PubMed PMID: 1715997.