N,N'-Ethylenediamine disuccinic acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597062

CAS#: 20846-91-7

Description: N,N'-Ethylenediamine disuccinic acid is an aminopolycarboxylic acid. It is a colourless solid that is used as chelating agent that may offer a biodegradable alternative to EDTA, which is currently used on a large scale in numerous applications. Isolated from Actinomycetes MG417-CF17.

Chemical Structure

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N,N'-Ethylenediamine disuccinic acid
CAS# 20846-91-7
Instruction

Theoretical Analysis

MedKoo Cat#: 597062
Name: N,N'-Ethylenediamine disuccinic acid
CAS#: 20846-91-7
Chemical Formula: C10H16N2O8
Exact Mass: 292.09
Molecular Weight: 292.240
Elemental Analysis: C, 41.10; H, 5.52; N, 9.59; O, 43.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: N,N'-Ethylenediamine disuccinic acid; EDDS; EDSS; L-Ethylenediaminedisuccinic acid;

IUPAC/Chemical Name: (2S,2'S)-2,2'-(ethane-1,2-diylbis(azanediyl))disuccinic acid

InChi Key: VKZRWSNIWNFCIQ-WDSKDSINSA-N

InChi Code: InChI=1S/C10H16N2O8/c13-7(14)3-5(9(17)18)11-1-2-12-6(10(19)20)4-8(15)16/h5-6,11-12H,1-4H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)/t5-,6-/m0/s1

SMILES Code: O=C(O)C[C@@H](C(O)=O)NCCN[C@@H](CC(O)=O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 292.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhou LY, Chen S, Li H, Guo S, Liu YD, Yang J. EDDS enhanced Shewanella putrefaciens CN32 and α-FeOOH reductive dechlorination of carbon tetrachloride. Chemosphere. 2018 May;198:556-564. doi: 10.1016/j.chemosphere.2018.01.083. Epub 2018 Jan 18. PubMed PMID: 29422245.

2: Dong H, Zeng Y, Xie Y, He Q, Zhao F, Wang Y, Zeng G. Single and combined removal of Cr(VI) and Cd(II) by nanoscale zero-valent iron in the absence and presence of EDDS. Water Sci Technol. 2017 Sep;76(5-6):1261-1271. doi: 10.2166/wst.2017.321. PubMed PMID: 28876268; PubMed Central PMCID: wst_2017_321.

3: Race M. Applicability of alkaline precipitation for the recovery of EDDS spent solution. J Environ Manage. 2017 Dec 1;203(Pt 1):358-363. doi: 10.1016/j.jenvman.2017.08.013. Epub 2017 Aug 12. PubMed PMID: 28806652.

4: Thanh PM, Ketheesan B, Yan Z, Stuckey D. Effect of Ethylenediamine-N,N'-disuccinic acid (EDDS) on the speciation and bioavailability of Fe(2+) in the presence of sulfide in anaerobic digestion. Bioresour Technol. 2017 Apr;229:169-179. doi: 10.1016/j.biortech.2016.12.113. Epub 2017 Jan 4. PubMed PMID: 28110234.

5: Zhang X, Gu X, Lu S, Miao Z, Xu M, Fu X, Qiu Z, Sui Q. Application of calcium peroxide activated with Fe(II)-EDDS complex in trichloroethylene degradation. Chemosphere. 2016 Oct;160:1-6. doi: 10.1016/j.chemosphere.2016.06.067. Epub 2016 Jun 25. PubMed PMID: 27351899.

6: Beiyuan J, Tsang DCW, Ok YS, Zhang W, Yang X, Baek K, Li XD. Integrating EDDS-enhanced washing with low-cost stabilization of metal-contaminated soil from an e-waste recycling site. Chemosphere. 2016 Sep;159:426-432. doi: 10.1016/j.chemosphere.2016.06.030. Epub 2016 Jun 20. PubMed PMID: 27337434.

7: Vigliotta G, Matrella S, Cicatelli A, Guarino F, Castiglione S. Effects of heavy metals and chelants on phytoremediation capacity and on rhizobacterial communities of maize. J Environ Manage. 2016 Sep 1;179:93-102. doi: 10.1016/j.jenvman.2016.04.055. Epub 2016 May 21. PubMed PMID: 27219351.

8: Satyro S, Race M, Marotta R, Dezotti M, Guida M, Clarizia L. Photocatalytic processes assisted by artificial solar light for soil washing effluent treatment. Environ Sci Pollut Res Int. 2017 Mar;24(7):6353-6360. doi: 10.1007/s11356-016-6431-9. Epub 2016 Apr 5. PubMed PMID: 27044292.

9: Spohn M, Wohlleben W, Stegmann E. Elucidation of the zinc-dependent regulation in Amycolatopsis japonicum enabled the identification of the ethylenediamine-disuccinate ([S,S]-EDDS) genes. Environ Microbiol. 2016 Apr;18(4):1249-63. doi: 10.1111/1462-2920.13159. Epub 2016 Jan 18. PubMed PMID: 26636770.

10: Marsh JM, Davis MG, Lucas RL, Reilman R, Styczynski PB, Li C, Mamak M, McComb DW, Williams RE, Godfrey S, Navqi KR, Chechik V. Preserving fibre health: reducing oxidative stress throughout the life of the hair fibre. Int J Cosmet Sci. 2015 Dec;37 Suppl 2:16-24. doi: 10.1111/ics.12285. Review. PubMed PMID: 26574301.

11: Wu Y, Bianco A, Brigante M, Dong W, de Sainte-Claire P, Hanna K, Mailhot G. Sulfate Radical Photogeneration Using Fe-EDDS: Influence of Critical Parameters and Naturally Occurring Scavengers. Environ Sci Technol. 2015 Dec 15;49(24):14343-9. doi: 10.1021/acs.est.5b03316. Epub 2015 Nov 24. PubMed PMID: 26554494.

12: Ferraro A, van Hullebusch ED, Huguenot D, Fabbricino M, Esposito G. Application of an electrochemical treatment for EDDS soil washing solution regeneration and reuse in a multi-step soil washing process: Case of a Cu contaminated soil. J Environ Manage. 2015 Nov 1;163:62-9. doi: 10.1016/j.jenvman.2015.08.004. Epub 2015 Aug 22. PubMed PMID: 26292775.

13: Yang L, Jiang L, Wang G, Chen Y, Shen Z, Luo C. Assessment of amendments for the immobilization of Cu in soils containing EDDS leachates. Environ Sci Pollut Res Int. 2015 Nov;22(21):16525-34. doi: 10.1007/s11356-015-4840-9. Epub 2015 Jun 17. PubMed PMID: 26077318.

14: Marsh JM, Davis MG, Flagler MJ, Sun Y, Chaudhary T, Mamak M, McComb DW, Williams RE, Greis KD, Rubio L, Coderch L. Advanced hair damage model from ultra-violet radiation in the presence of copper. Int J Cosmet Sci. 2015 Oct;37(5):532-41. doi: 10.1111/ics.12231. Epub 2015 Jun 9. PubMed PMID: 25923177.

15: Luo C, Wang S, Wang Y, Yang R, Zhang G, Shen Z. Effects of EDDS and plant-growth-promoting bacteria on plant uptake of trace metals and PCBs from e-waste-contaminated soil. J Hazard Mater. 2015 Apr 9;286:379-85. doi: 10.1016/j.jhazmat.2015.01.010. Epub 2015 Jan 6. PubMed PMID: 25658198.

16: Hu MH, Yuan JH. Changes in the spectral pattern of selenium accumulation in Coleus blumei and the effects of chelation. Ecotoxicology. 2015 Apr;24(3):686-99. doi: 10.1007/s10646-014-1415-3. Epub 2015 Jan 8. PubMed PMID: 25567191.

17: Morrison PW, Khutoryanskiy VV. Enhancement in corneal permeability of riboflavin using calcium sequestering compounds. Int J Pharm. 2014 Sep 10;472(1-2):56-64. doi: 10.1016/j.ijpharm.2014.06.007. Epub 2014 Jun 10. PubMed PMID: 24928133; PubMed Central PMCID: PMC4111866.

18: Vamerali T, Bandiera M, Lucchini P, Mosca G. Metal partitioning in plant-substrate-water compartments under EDDS-assisted phytoextraction of pyrite waste with Brassica carinata A. Braun. Environ Sci Pollut Res Int. 2015 Feb;22(4):2434-46. doi: 10.1007/s11356-014-3003-8. Epub 2014 May 27. PubMed PMID: 24859698.

19: Tan J, He S, Yan S, Li Y, Li H, Zhang H, Zhao L, Li L. Exogenous EDDS modifies copper-induced various toxic responses in rice. Protoplasma. 2014 Sep;251(5):1213-21. doi: 10.1007/s00709-014-0628-x. Epub 2014 Mar 5. PubMed PMID: 24595621.

20: Tsang DC, Hartley NR. Metal distribution and spectroscopic analysis after soil washing with chelating agents and humic substances. Environ Sci Pollut Res Int. 2014 Mar;21(5):3987-95. doi: 10.1007/s11356-013-2300-y. Epub 2013 Dec 3. PubMed PMID: 24297462.