WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563055

CAS#: 303196-31-8

Description: R1498 is an inhibitor of cyclin-dependent kinase 2 (CDK2). It is well-tolerated and orally active for hepatocellular carcinoma and gastric cancer treatment and acts via targeting angiogenesis and mitosis pathways.

Chemical Structure

CAS# 303196-31-8

Theoretical Analysis

MedKoo Cat#: 563055
Name: R1498
CAS#: 303196-31-8
Chemical Formula: C18H15ClN4O
Exact Mass: 338.0934
Molecular Weight: 338.79
Elemental Analysis: C, 63.81; H, 4.46; Cl, 10.46; N, 16.54; O, 4.72

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: R1498; R-1498; R 1498;

IUPAC/Chemical Name: 5-(2-Chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine


InChi Code: InChI=1S/C18H15ClN4O/c1-10-16-18(23-22-10)20-15-8-7-11(24-2)9-13(15)17(21-16)12-5-3-4-6-14(12)19/h3-9H,1-2H3,(H2,20,22,23)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 338.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Thunhorst RL, Beltz TG, Johnson AK. Effects of aging on mineralocorticoid-induced salt appetite in rats. Am J Physiol Regul Integr Comp Physiol. 2013 Dec 15;305(12):R1498-505. doi: 10.1152/ajpregu.00349.2013. Epub 2013 Oct 16. PubMed PMID: 24133100; PubMed Central PMCID: PMC3882696.

2: Zhang C, Wu X, Zhang M, Zhu L, Zhao R, Xu D, Lin Z, Liang C, Chen T, Chen L, Ren Y, Zhang J, Qin N, Zhang X. Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways. PLoS One. 2013 Jun 5;8(6):e65264. doi: 10.1371/journal.pone.0065264. Print 2013. PubMed PMID: 23755206; PubMed Central PMCID: PMC3673949.

3: Ray R, Herring CM, Markel TA, Crisostomo PR, Wang M, Weil B, Lahm T, Meldrum DR. Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production. Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1498-503. doi: 10.1152/ajpregu.00897.2007. Epub 2008 Mar 12. PubMed PMID: 18337309.