WC-9

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563050

CAS#: 205381-53-9

Description: WC-9 is a squalene synthase (SQS) inhibitor that acts by binding to TcSQS and HsSQS.


Chemical Structure

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WC-9
CAS# 205381-53-9

Theoretical Analysis

MedKoo Cat#: 563050
Name: WC-9
CAS#: 205381-53-9
Chemical Formula: C15H13NO2S
Exact Mass: 271.0667
Molecular Weight: 271.33
Elemental Analysis: C, 66.40; H, 4.83; N, 5.16; O, 11.79; S, 11.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WC-9; WC 9; WC9;

IUPAC/Chemical Name: 1-Phenoxy-4-(2-thiocyanato-ethoxy)-benzene

InChi Key: YQZHGQYIMXWEHI-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H13NO2S/c16-12-19-11-10-17-13-6-8-15(9-7-13)18-14-4-2-1-3-5-14/h1-9H,10-11H2

SMILES Code: N#CSCCOC1=CC=C(OC2=CC=CC=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 271.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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2: Chao MN, Storey M, Li C, Rodríguez MG, Di Salvo F, Szajnman SH, Moreno SNJ, Docampo R, Rodriguez JB. Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation. Bioorg Med Chem. 2017 Dec 15;25(24):6435-6449. doi: 10.1016/j.bmc.2017.10.016. Epub 2017 Oct 16. PubMed PMID: 29107437.

3: Chao MN, Li C, Storey M, Falcone BN, Szajnman SH, Bonesi SM, Docampo R, Moreno SN, Rodriguez JB. Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem. 2016 Dec 16;11(24):2690-2702. doi: 10.1002/cmdc.201600505. Epub 2016 Nov 25. PubMed PMID: 27886451; PubMed Central PMCID: PMC5200956.

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5: Rodriguez JB. WC-9 a Lead Drug with Great Prospects for American Trypanosomiasis and Toxoplasmosis. Mini Rev Med Chem. 2016;16(15):1195-1200. Review. PubMed PMID: 27290911.

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11: Elicio PD, Chao MN, Galizzi M, Li C, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB. Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents. Eur J Med Chem. 2013 Nov;69:480-9. doi: 10.1016/j.ejmech.2013.09.009. Epub 2013 Sep 18. PubMed PMID: 24090919; PubMed Central PMCID: PMC3831659.

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