R243
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MedKoo CAT#: 563044

CAS#: 688352-84-3

Description: R243 is an inhibitor of CCR8 signaling and chemotaxis.


Chemical Structure

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R243
CAS# 688352-84-3

Theoretical Analysis

MedKoo Cat#: 563044
Name: R243
CAS#: 688352-84-3
Chemical Formula: C21H27NO4
Exact Mass: 357.194
Molecular Weight: 357.45
Elemental Analysis: C, 70.56; H, 7.61; N, 3.92; O, 17.90

Price and Availability

Size Price Availability Quantity
10.0mg USD 135.0 Ready to ship
25.0mg USD 250.0 Ready to ship
50.0mg USD 450.0 Ready to ship
100.0mg USD 750.0 Ready to ship
200.0mg USD 1250.0 Ready to ship
500.0mg USD 2450.0 Ready to ship
1.0g USD 3650.0 2 Weeks
2.0g USD 5850.0 2 Weeks
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Synonym: R243; R-243; R 243;

IUPAC/Chemical Name: 7,8-Dihydro-7-[2-(tricyclo[3.3.1.1(3,7)]dec-1-yloxy)ethyl]-6H-1,3-dioxolo[4,5-g][1,3]benzoxazine

InChi Key: JJMLDSFDOODCIR-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27NO4/c1(2-26-21-8-14-3-15(9-21)5-16(4-14)10-21)22-11-17-6-19-20(25-13-24-19)7-18(17)23-12-22/h6-7,14-16H,1-5,8-13H2

SMILES Code: N1(CCOC2(C3)CC4CC3CC(C4)C2)COC5=CC(OCO6)=C6C=C5C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 357.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Berenguer J, Lagerweij T, Zhao XW, Dusoswa S, van der Stoop P, Westerman B, de Gooijer MC, Zoetemelk M, Zomer A, Crommentuijn MHW, Wedekind LE, López-López À, Giovanazzi A, Bruch-Oms M, van der Meulen-Muileman IH, Reijmers RM, van Kuppevelt TH, García-Vallejo JJ, van Kooyk Y, Tannous BA, Wesseling P, Koppers-Lalic D, Vandertop WP, Noske DP, van Beusechem VW, van Rheenen J, Pegtel DM, van Tellingen O, Wurdinger T. Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. J Extracell Vesicles. 2018 Mar 13;7(1):1446660. doi: 10.1080/20013078.2018.1446660. eCollection 2018. PubMed PMID: 29696074; PubMed Central PMCID: PMC5912193.

2: Huber DA, Schreihofer AM. Exaggerated sympathoexcitatory reflexes develop with changes in the rostral ventrolateral medulla in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R243-53. doi: 10.1152/ajpregu.00085.2016. Epub 2016 Jun 8. PubMed PMID: 27280427; PubMed Central PMCID: PMC5008660.

3: Wan H, Otsuka Y, Gao ZQ, Wei Y, Chen Z, Masuda M, Yonesaki T, Zhang H, Dong YH. Structural insights into the inhibition mechanism of bacterial toxin LsoA by bacteriophage antitoxin Dmd. Mol Microbiol. 2016 Sep;101(5):757-69. doi: 10.1111/mmi.13420. Epub 2016 Jun 2. PubMed PMID: 27169810.

4: Richards MB, Soares P, Torroni A. Palaeogenomics: Mitogenomes and Migrations in Europe's Past. Curr Biol. 2016 Mar 21;26(6):R243-6. doi: 10.1016/j.cub.2016.01.044. PubMed PMID: 27003890.

5: Palamarchuk IS, Baker J, Kimpinski K. The utility of Valsalva maneuver in the diagnoses of orthostatic disorders. Am J Physiol Regul Integr Comp Physiol. 2016 Feb 1;310(3):R243-52. doi: 10.1152/ajpregu.00290.2015. Epub 2015 Oct 21. PubMed PMID: 26491102.

6: Busiek KK, Margolin W. Bacterial actin and tubulin homologs in cell growth and division. Curr Biol. 2015 Mar 16;25(6):R243-R254. doi: 10.1016/j.cub.2015.01.030. Review. PubMed PMID: 25784047; PubMed Central PMCID: PMC5519336.

7: Oshio T, Kawashima R, Kawamura YI, Hagiwara T, Mizutani N, Okada T, Otsubo T, Inagaki-Ohara K, Matsukawa A, Haga T, Kakuta S, Iwakura Y, Hosokawa S, Dohi T. Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. PLoS One. 2014 Apr 8;9(4):e94445. doi: 10.1371/journal.pone.0094445. eCollection 2014. PubMed PMID: 24714157; PubMed Central PMCID: PMC3979852.

8: Pavlou HJ, Neville MC, Goodwin SF. Aggression: tachykinin is all the rage. Curr Biol. 2014 Mar 17;24(6):R243-4. doi: 10.1016/j.cub.2014.02.017. PubMed PMID: 24650914.

9: Moraes DP, Sassi FC, Mangilli LD, Zilberstein B, de Andrade CR. Clinical prognostic indicators of dysphagia following prolonged orotracheal intubation in ICU patients. Crit Care. 2013 Oct 18;17(5):R243. doi: 10.1186/cc13069. PubMed PMID: 24138781; PubMed Central PMCID: PMC4056041.

10: Li R, Xie DD, Dong JH, Li H, Li KS, Su J, Chen LZ, Xu YF, Wang HM, Gong Z, Cui GY, Yu X, Wang K, Yao W, Xin T, Li MY, Xiao KH, An XF, Huo Y, Xu ZG, Sun JP, Pang Q. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase. J Neurochem. 2014 Jan;128(2):315-329. doi: 10.1111/jnc.12463. Epub 2013 Oct 31. Erratum in: J Neurochem. 2015 Sep;134(5):978. PubMed PMID: 24117863; PubMed Central PMCID: PMC3947313.

11: Bailey MR, Balsam PD. Memory reconsolidation: time to change your mind. Curr Biol. 2013 Mar 18;23(6):R243-5. doi: 10.1016/j.cub.2013.02.006. PubMed PMID: 23518056; PubMed Central PMCID: PMC4864982.

12: Chandani S, Loechler EL. Structural model of the Y-Family DNA polymerase V/RecA mutasome. J Mol Graph Model. 2013 Feb;39:133-44. doi: 10.1016/j.jmgm.2012.09.005. Epub 2012 Nov 27. PubMed PMID: 23266508; PubMed Central PMCID: PMC3557540.

13: Hutcheson J, Vanarsa K, Bashmakov A, Grewal S, Sajitharan D, Chang BY, Buggy JJ, Zhou XJ, Du Y, Satterthwaite AB, Mohan C. Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus. Arthritis Res Ther. 2012 Nov 8;14(6):R243. doi: 10.1186/ar4086. PubMed PMID: 23136880; PubMed Central PMCID: PMC3674619.

14: Shiota M, Yokomizo A, Naito S. Pro-survival and anti-apoptotic properties of androgen receptor signaling by oxidative stress promote treatment resistance in prostate cancer. Endocr Relat Cancer. 2012 Nov 9;19(6):R243-53. doi: 10.1530/ERC-12-0232. Print 2012 Dec. Review. PubMed PMID: 23033314.

15: Andaluz-Ojeda D, Iglesias V, Bobillo F, Almansa R, Rico L, Gandía F, Loma AM, Nieto C, Diego R, Ramos E, Nocito M, Resino S, Eiros JM, Tamayo E, de Lejarazu RO, Bermejo-Martin JF. Early natural killer cell counts in blood predict mortality in severe sepsis. Crit Care. 2011;15(5):R243. doi: 10.1186/cc10501. Epub 2011 Oct 21. PubMed PMID: 22018048; PubMed Central PMCID: PMC3334794.

16: Garcia-Marcos M, Ghosh P, Farquhar MG. Molecular basis of a novel oncogenic mutation in GNAO1. Oncogene. 2011 Jun 9;30(23):2691-6. doi: 10.1038/onc.2010.645. Epub 2011 Feb 14. PubMed PMID: 21317923; PubMed Central PMCID: PMC3349449.

17: Hofgaard JP, Mollerup S, Holstein-Rathlou NH, Nielsen MS. Quantification of gap junctional intercellular communication based on digital image analysis. Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R243-7. doi: 10.1152/ajpregu.00089.2009. Epub 2009 Jun 17. PubMed PMID: 19535680.

18: Mullen KL, Pritchard J, Ritchie I, Snook LA, Chabowski A, Bonen A, Wright D, Dyck DJ. Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats. Am J Physiol Regul Integr Comp Physiol. 2009 Feb;296(2):R243-51. doi: 10.1152/ajpregu.90774.2008. Epub 2008 Dec 10. PubMed PMID: 19073900.

19: Hand JW. Modelling the interaction of electromagnetic fields (10 MHz-10 GHz) with the human body: methods and applications. Phys Med Biol. 2008 Aug 21;53(16):R243-86. doi: 10.1088/0031-9155/53/16/R01. Epub 2008 Jul 24. Review. PubMed PMID: 18653928.

20: Mutolo D, Bongianni F, Cinelli E, Fontana GA, Pantaleo T. Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit. Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R243-51. doi: 10.1152/ajpregu.00184.2008. Epub 2008 May 14. PubMed PMID: 18480245.

R243

10.0mg / USD 135.0