L-Neopterin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597054

CAS#: 2277-43-2

Description: L-Neopterin is a cholinergic receptor.

Chemical Structure

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L-Neopterin
CAS# 2277-43-2
Instruction

Theoretical Analysis

MedKoo Cat#: 597054
Name: L-Neopterin
CAS#: 2277-43-2
Chemical Formula: C9H11N5O4
Exact Mass: 253.08
Molecular Weight: 253.210
Elemental Analysis: C, 42.69; H, 4.38; N, 27.66; O, 25.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Neopterin, L-erythro-; L-Neopterin; Neopterin, L-(-)-; L-Erythro-neopterin;

IUPAC/Chemical Name: 2-amino-6-((1R,2S)-1,2,3-trihydroxypropyl)pteridin-4(1H)-one

InChi Key: BMQYVXCPAOLZOK-UJURSFKZSA-N

InChi Code: InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m0/s1

SMILES Code: O=C1N=C(N)NC2=NC=C([C@@H](O)[C@@H](O)CO)N=C12

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 253.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nomura T, Tazawa M, Ohtsuki M, Sumi-Ichinose C, Hagino Y, Ota A, Nakashima A, Mori K, Sugimoto T, Ueno O, Nozawa Y, Ichinose H, Nagatsu T. Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis. Presence of GTP cyclohydrolase I. Comp Biochem Physiol B Biochem Mol Biol. 1998 Aug;120(4):753-60. PubMed PMID: 9854821.

2: Tani Y, Ishihara T, Kanai T, Ohno T, Andersson J, Lilja A, Antoni G, Fasth KJ, Bjurling P, Westerberg G, et al. Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopaminergic and cholinergic receptors as evaluated by positron emission tomography in the Rhesus monkey. J Neural Transm Gen Sect. 1995;102(3):189-208. PubMed PMID: 8788068.

3: Curtius HC, Matasovic A, Schoedon G, Kuster T, Guibaud P, Giudici T, Blau N. 7-Substituted pterins. A new class of mammalian pteridines. J Biol Chem. 1990 Mar 5;265(7):3923-30. PubMed PMID: 2303485.

4: Curtius HC, Kuster T, Matasovic A, Blau N, Dhondt JL. Primapterin, anapterin, and 6-oxo-primapterin, three new 7-substituted pterins identified in a patient with hyperphenylalaninemia. Biochem Biophys Res Commun. 1988 Jun 16;153(2):715-21. PubMed PMID: 3382399.

5: Kuster T, Matasović A, Niederwieser A. Application of gas chromatography-mass spectrometry to the study of biopterin metabolism in man. Detection of biolumazine and 2'-deoxysepialumazine. J Chromatogr. 1984 May 4;290:303-10. PubMed PMID: 6547448.

6: Niederwieser A, Blau N, Wang M, Joller P, Atarés M, Cardesa-Garcia J. GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia. Eur J Pediatr. 1984 Feb;141(4):208-14. PubMed PMID: 6734669.

7: Niederwieser A, Curtius HC, Bettoni O, Bieri J, Schircks B, Viscontini M, Schaub J. Atypical phenylketonuria caused by 7, 8-dihydrobiopterin synthetase deficiency. Lancet. 1979 Jan 20;1(8108):131-3. PubMed PMID: 84153.

8: Eto I, Fukushima K, Shiota T. Enzymatic synthesis of biopterin from D-erythrodihydroneopterin triphosphate by extracts of kidneys from Syrian golden hamsters. J Biol Chem. 1976 Nov 10;251(21):6505-12. PubMed PMID: 10299.