WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558151

CAS#: 64849-39-4

Description: Rubusoside is a natural sweetener.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-27. Prices are subject to change without notice.

Rubusoside, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 558151
Name: Rubusoside
CAS#: 64849-39-4
Chemical Formula: C32H50O13
Exact Mass: 642.33
Molecular Weight: 642.74
Elemental Analysis: C, 59.80; H, 7.84; O, 32.36

Synonym: UNII-TCV5K3M3GX;

IUPAC/Chemical Name: Kaur-16-en-18-oic acid, 13-(beta-D-glucopyranosyloxy)-, beta-D-glucopyranosyl ester, (4alpha)-


InChi Code: InChI=1S/C32H50O13/c1-15-11-31-9-5-18-29(2,7-4-8-30(18,3)28(41)44-26-24(39)22(37)20(35)16(12-33)42-26)19(31)6-10-32(15,14-31)45-27-25(40)23(38)21(36)17(13-34)43-27/h16-27,33-40H,1,4-14H2,2-3H3/t16-,17-,18+,19+,20-,21-,22+,23+,24-,25-,26+,27+,29-,30-,31-,32+/m1/s1

SMILES Code: C=C([C@@](CC1)(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)C3)C[C@@]43CC[C@]5([H])[C@@](C(O[C@H]6[C@@H]([C@H]([C@@H]([C@@H](CO)O6)O)O)O)=O)(C)CCC[C@@]5(C)[C@@]41[H]

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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2: Wang Z, Wang J, Jiang M, Wei Y, Pang H, Wei H, Huang R, Du L. Selective production of rubusoside from stevioside by using the sophorose activity of β-glucosidase from Streptomyces sp. GXT6. Appl Microbiol Biotechnol. 2015 Nov;99(22):9663-74. doi: 10.1007/s00253-015-6802-z. Epub 2015 Jul 22. PubMed PMID: 26198882.

3: Nguyen TT, Jung SJ, Kang HK, Kim YM, Moon YH, Kim M, Kim D. Production of rubusoside from stevioside by using a thermostable lactase from Thermus thermophilus and solubility enhancement of liquiritin and teniposide. Enzyme Microb Technol. 2014 Oct;64-65:38-43. doi: 10.1016/j.enzmictec.2014.07.001. Epub 2014 Jul 11. PubMed PMID: 25152415.

4: Chu J, Zhang T, He K. Cariogenicity features of Streptococcus mutans in presence of rubusoside. BMC Oral Health. 2016 May 11;16(1):54. doi: 10.1186/s12903-016-0212-1. PubMed PMID: 27169524; PubMed Central PMCID: PMC4864916.

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6: Zhang J, Chou G, Liu Z, Liu M. Employing rubusoside to improve the solubility and permeability of antitumor compound betulonic acid. Nanomedicine (Lond). 2016 Oct 19. [Epub ahead of print] PubMed PMID: 27759492.

7: Ko JA, Kim YM, Ryu YB, Jeong HJ, Park TS, Park SJ, Wee YJ, Kim JS, Kim D, Lee WS. Mass production of rubusoside using a novel stevioside-specific β-glucosidase from Aspergillus aculeatus. J Agric Food Chem. 2012 Jun 20;60(24):6210-6. doi: 10.1021/jf300531e. Epub 2012 Jun 1. PubMed PMID: 22530920.

8: George Thompson AM, Iancu CV, Nguyen TT, Kim D, Choe JY. Inhibition of human GLUT1 and GLUT5 by plant carbohydrate products; insights into transport specificity. Sci Rep. 2015 Aug 26;5:12804. doi: 10.1038/srep12804. PubMed PMID: 26306809; PubMed Central PMCID: PMC4549712.

9: Jiang Z, Chen Y, Liu H. [Identification and biotransformation properties of a bacterium that converts stevioside into rubusoside]. Wei Sheng Wu Xue Bao. 2011 Jan;51(1):43-9. Chinese. PubMed PMID: 21465788.

10: Sugimoto N, Sato K, Liu HM, Kikuchi H, Yamazaki T, Maitani T. Analysis of rubusoside and related compounds in tenryocha extract sweetener. Shokuhin Eiseigaku Zasshi. 2002 Aug;43(4):250-3. PubMed PMID: 12436720.

11: Liu Z, Zhang F, Koh GY, Dong X, Hollingsworth J, Zhang J, Russo PS, Yang P, Stout RW. Cytotoxic and antiangiogenic paclitaxel solubilized and permeation-enhanced by natural product nanoparticles. Anticancer Drugs. 2015 Feb;26(2):167-79. doi: 10.1097/CAD.0000000000000173. PubMed PMID: 25243454; PubMed Central PMCID: PMC4272611.

12: Ohtani K, Aikawa Y, Ishikawa H, Kasai R, Kitahata S, Mizutani K, Doi S, Nakaura M, Tanaka O. Further study on the 1,4-alpha-transglucosylation of rubusoside, a sweet steviol-bisglucoside from Rubus suavissimus. Agric Biol Chem. 1991 Feb;55(2):449-53. PubMed PMID: 1368695.

13: Ko JA, Ryu YB, Park JY, Kim CY, Kim JS, Nam SH, Lee WS, Kim YM. Glucosyl Rubusosides by Dextransucrases Improve the Quality of Taste and Sweetness. J Microbiol Biotechnol. 2016 Mar;26(3):493-7. doi: 10.4014/jmb.1512.12085. PubMed PMID: 26809800.

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15: Well C, Frank O, Hofmann T. Quantitation of sweet steviol glycosides by means of a HILIC-MS/MS-SIDA approach. J Agric Food Chem. 2013 Nov 27;61(47):11312-20. doi: 10.1021/jf404018g. Epub 2013 Nov 19. PubMed PMID: 24206531.

16: Chaturvedula VS, Upreti M, Prakash I. Diterpene glycosides from Stevia rebaudiana. Molecules. 2011 Apr 28;16(5):3552-62. doi: 10.3390/molecules16053552. PubMed PMID: 21527882.

17: Ohtani K, Aikawa Y, Fujisawa Y, Kasai R, Tanaka O, Yamasaki K. Solubilization of steviolbioside and steviolmonoside with gamma-cyclodextrin and its application to selective syntheses of better sweet glycosides from stevioside and rubusoside. Chem Pharm Bull (Tokyo). 1991 Dec;39(12):3172-4. PubMed PMID: 1814608.

18: Zhang F, Koh GY, Jeansonne DP, Hollingsworth J, Russo PS, Vicente G, Stout RW, Liu Z. A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity. J Pharm Sci. 2011 Jul;100(7):2778-89. doi: 10.1002/jps.22512. Epub 2011 Feb 10. PubMed PMID: 21312196.

19: Liu D, Chen Z. The effect of curcumin on breast cancer cells. J Breast Cancer. 2013 Jun;16(2):133-7. doi: 10.4048/jbc.2013.16.2.133. Epub 2013 Jun 28. PubMed PMID: 23843843; PubMed Central PMCID: PMC3706856.

20: Jeansonne DP, Koh GY, Zhang F, Kirk-Ballard H, Wolff L, Liu D, Eilertsen K, Liu Z. Paclitaxel-induced apoptosis is blocked by camptothecin in human breast and pancreatic cancer cells. Oncol Rep. 2011 May;25(5):1473-80. doi: 10.3892/or.2011.1187. Epub 2011 Feb 17. PubMed PMID: 21331447.