WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206866
Description: Gusacitinib, also known as ASN-002, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and Pfeiffer.
MedKoo Cat#: 206866
Chemical Formula: C24H28N8O2
Exact Mass: 460.2335
Molecular Weight: 460.542
Elemental Analysis: C, 62.59; H, 6.13; N, 24.33; O, 6.95
Synonym: ASN-002; ASN 002; ASN002; Gusacitinib
IUPAC/Chemical Name: 1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile
InChi Key: NLFLXLJXEIUQDL-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)
SMILES Code: N#CCC1CCN(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C5C(C=NNC5=O)=N2)CC1
IC50 of 5-46 nM in biochemical assays
2. Kinase Inhibitors for the Treatment of Immunological Disorders: Marian C. Bryan, and Naomi S. Rajapaksa; Publication Date (Web): June 5, 2018 (Perspective); DOI: 10.1021/acs.jmedchem.8b00667