WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 533018
CAS#: 1449742-87-3
Description: AM-6226 is a Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. AM-6226 is the first molecule to display significant glucose lowering in cynomolgus monkeys providing additional evidence that GPR40 full agonists afford access to a powerful mechanism for maintaining glycemic control.
MedKoo Cat#: 533018
Name: AM-6226
CAS#: 1449742-87-3
Chemical Formula: C32H36F2O4
Exact Mass: 522.2582
Molecular Weight: 522.6328
Elemental Analysis: C, 73.54; H, 6.94; F, 7.27; O, 12.24
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Related CAS #: 1449742-87-3 (RR isomer)
Synonym: AM-6226; AM 6226; AM6226;
IUPAC/Chemical Name: (R)-3-{3-[2-((S)-2,2-Dimethyl-cyclopentyl)-2'-fluoro-5'-methoxy-biphenyl-4-ylmethoxy]-2-fluoro-phenyl}-pentanoic acid
InChi Key: CUBDGLIBZGKXKQ-ZBLYBZFDSA-N
InChi Code: InChI=1S/C32H36F2O4/c1-5-21(17-30(35)36)23-8-6-10-29(31(23)34)38-19-20-11-13-24(26-18-22(37-4)12-14-28(26)33)25(16-20)27-9-7-15-32(27,2)3/h6,8,10-14,16,18,21,27H,5,7,9,15,17,19H2,1-4H3,(H,35,36)/t21-,27+/m1/s1
SMILES Code: CC[C@@H](C1=CC=CC(OCC(C=C2[C@@H]3CCCC(C)3C)=CC=C2C4=CC(OC)=CC=C4F)=C1F)CC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 522.6328 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Luo J, Swaminath G, Brown SP, Zhang J, Guo Q, Chen M, Nguyen K, Tran T, Miao
L, Dransfield PJ, Vimolratana M, Houze JB, Wong S, Toteva M, Shan B, Li F, Zhuang
R, Lin DC. A potent class of GPR40 full agonists engages the enteroinsular axis
to promote glucose control in rodents. PLoS One. 2012;7(10):e46300. doi:
10.1371/journal.pone.0046300. Epub 2012 Oct 9. PubMed PMID: 23056280; PubMed
Central PMCID: PMC3467217.
