SB-414796

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563009

CAS#: 264262-71-7

Description: SB-414796 is a potent and selective dopamine D3 receptor antagonist.


Chemical Structure

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SB-414796
CAS# 264262-71-7

Theoretical Analysis

MedKoo Cat#: 563009
Name: SB-414796
CAS#: 264262-71-7
Chemical Formula: C29H36N4O4S
Exact Mass: 536.25
Molecular Weight: 536.690
Elemental Analysis: C, 64.90; H, 6.76; N, 10.44; O, 11.92; S, 5.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SB-414796; SB 414796; SB414796;

IUPAC/Chemical Name: 3-(5-methyl-1,2,4-oxadiazol-3-yl)-N-((1r,4r)-4-(2-(7-(methylsulfonyl)-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)ethyl)cyclohexyl)benzamide

InChi Key: ZHQUFEJLPBTKSM-WVPZODRTSA-N

InChi Code: InChI=1S/C29H36N4O4S/c1-20-30-28(32-37-20)24-4-3-5-25(18-24)29(34)31-26-9-6-21(7-10-26)12-15-33-16-13-22-8-11-27(38(2,35)36)19-23(22)14-17-33/h3-5,8,11,18-19,21,26H,6-7,9-10,12-17H2,1-2H3,(H,31,34)/t21-,26-

SMILES Code: CS(C1=CC2=C(CCN(CC[C@H]3CC[C@H](NC(C4=CC=CC(C5=NOC(C)=N5)=C4)=O)CC3)CC2)C=C1)(=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 536.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lacroix LP, Ceolin L, Zocchi A, Varnier G, Garzotti M, Curcuruto O, Heidbreder CA. Selective dopamine D3 receptor antagonists enhance cortical acetylcholine levels measured with high-performance liquid chromatography/tandem mass spectrometry without anti-cholinesterases. J Neurosci Methods. 2006 Oct 15;157(1):25-31. Epub 2006 May 11. PubMed PMID: 16697046.

2: Heidbreder CA, Gardner EL, Xi ZX, Thanos PK, Mugnaini M, Hagan JJ, Ashby CR Jr. The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence. Brain Res Brain Res Rev. 2005 Jul;49(1):77-105. Review. PubMed PMID: 15960988; PubMed Central PMCID: PMC3732040.

3: Macdonald GJ, Branch CL, Hadley MS, Johnson CN, Nash DJ, Smith AB, Stemp G, Thewlis KM, Vong AK, Austin NE, Jeffrey P, Winborn KY, Boyfield I, Hagan JJ, Middlemiss DN, Reavill C, Riley GJ, Watson JM, Wood M, Parker SG, Ashby CR Jr. Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-ben zazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist. J Med Chem. 2003 Nov 6;46(23):4952-64. PubMed PMID: 14584946.