Carbidine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558103

CAS#: 33162-17-3

Description: Carbidine is a neuroleptic drug.


Chemical Structure

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Carbidine
CAS# 33162-17-3

Theoretical Analysis

MedKoo Cat#: 558103
Name: Carbidine
CAS#: 33162-17-3
Chemical Formula: C13H20Cl2N2
Exact Mass: 274.1
Molecular Weight: 275.22
Elemental Analysis: C, 56.73; H, 7.33; Cl, 25.76; N, 10.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Carbidin; Carbidine; Carbidine dihydrochloride; Karbidin; Karbidine;

IUPAC/Chemical Name: 5H-Pyrido(4,3-b)indole, 1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-, dihydrochloride

InChi Key: XWLFAMANDIWUKH-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H18N2.2ClH/c1-9-3-4-12-10(7-9)11-8-15(2)6-5-13(11)14-12;;/h3-4,7,11,13-14H,5-6,8H2,1-2H3;2*1H

SMILES Code: CC1=CC2=C(NC3C2CN(C)CC3)C=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 275.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gainetdinov RR, Sotnikova TD, Grekhova TV, Rayevsky KS. Simultaneous monitoring of dopamine, its metabolites and trans-isomer of atypical neuroleptic drug carbidine concentrations in striatal dialysates of conscious rats. Prog Neuropsychopharmacol Biol Psychiatry. 1996 Feb;20(2):291-305. PubMed PMID: 8861194.

2: Kudrin VS, Hetey L, Morgenshtern R, Raevskiĭ KS, Olssner W. [Effect of the atypical neuroleptics carbidine and sulpiride on dopamine biosynthesis in the synaptosomes of the nucleus accumbens septi in rats]. Farmakol Toksikol. 1987 Mar-Apr;50(2):16-20. Russian. PubMed PMID: 2884129.

3: Zharkovskiĭ AM, Klassen NE, Zharkovskiĭ TA. [Effect of carbidine on the dopamine and serotonin receptors of the central nervous system]. Biull Eksp Biol Med. 1985 Jun;99(6):700-2. Russian. PubMed PMID: 2861866.

4: Proskuriakova TV, Gurtovenko VM, Gorshkova EP. [Comparative evaluation of the effect of carbidine and levamisole on the E-rosette-forming activity of the lymphocytes in alcoholic intoxication]. Farmakol Toksikol. 1989 Jan-Feb;52(1):94-8. Russian. PubMed PMID: 2565251.

5: Zharkovskiĭ AM, Chereshka KS, Zharkovskaia TA, Allikmets LKh. [Changes in the sensitivity of brain dopamine and serotonin receptors during the prolonged administration of carbidine]. Biull Eksp Biol Med. 1985 Dec;100(12):719-22. Russian. PubMed PMID: 2866801.

6: Guinetdinov RR, Bogdanov MB, Pogorelov VM, Kudrin VS, Rayevsky KS. Stereoisomers of the atypical neuroleptic carbidine modulate striatal dopamine release in awake rats. Neuropharmacology. 1991 Nov;30(11):1251-4. PubMed PMID: 1685561.

7: Gurtovenko VM, Kuznetsova NI, Shumaĭlov IN, Proskuriakova TV, Eremina RV. [Effect of carbidine on parameters of ethanol oxidation in experimental alcoholic intoxication]. Farmakol Toksikol. 1989 May-Jun;52(3):83-6. Russian. PubMed PMID: 2571520.

8: Gaĭnetdinov RR, Miroshnichenko II, Kudrin VS, Bogdanov MB, Pogorelov VM, Budygin EA, Kovalev GI, Raevskiĭ KS. [A comparative study of the neurochemical profiles of carbidine stereoisomers]. Eksp Klin Farmakol. 1993 Jan-Feb;56(1):24-7. Russian. PubMed PMID: 8100728.

9: Miroshnichenko II, Kudrin VS, Raevskiĭ KS. [Effect of carbidine, sulpiride and haloperidol on levels of monoamines and their metabolites in the brain structures of rats]. Farmakol Toksikol. 1988 Mar-Apr;51(2):26-9. Russian. PubMed PMID: 2897932.

10: Malikova LA, Arefolov VA. [Effect of carbidine on dopamine turnover in the rat corpus striatum]. Farmakol Toksikol. 1980 May-Jun;43(3):310-3. Russian. PubMed PMID: 6108865.

11: Arefolov VA, Panasiuk LV. [Effect of carbidine on the content and storage of adrenergic neurotransmitter in the synaptic vesicles]. Biull Eksp Biol Med. 1975 Oct;80(10):69-72. Russian. PubMed PMID: 6093.

12: Sreenilayam G, Fasan R. Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates. Chem Commun (Camb). 2015 Jan 28;51(8):1532-4. doi: 10.1039/c4cc08753d. Erratum in: Chem Commun (Camb). 2015 Jan 31;51(9):1744. PubMed PMID: 25504318; PubMed Central PMCID: PMC4282819.

13: Xie Y, Yu C, Li T, Tu S, Yao C. An NHC-catalyzed in situ activation strategy to β-functionalize saturated carboxylic acid: an enantioselective formal [3+2] annulation for spirocyclic oxindolo-γ-butyrolactones. Chemistry. 2015 Mar 27;21(14):5355-9. doi: 10.1002/chem.201500345. Epub 2015 Feb 16. PubMed PMID: 25689040.

14: Arefolov VA, Panasiuk LV. [Effect of carbidine on the process of adrenergic neurotransmission]. Biull Eksp Biol Med. 1975 Jun;79(6):66-9. Russian. PubMed PMID: 177124.

15: Komendantova MV, Larentsova LI, Golobokiĭ NK. [Effect of carbidine and its combinations with pyranal on pain sensitivity in man]. Farmakol Toksikol. 1972 Mar-Apr;35(2):137-41. Russian. PubMed PMID: 5021641.

16: Barkov NK, Ostrovskaia RU. [Effect of carbidine on conditioned defense reflexes]. Biull Eksp Biol Med. 1975 Apr;79(4):61-4. Russian. PubMed PMID: 105.

17: Arefolov VA, Panasiuk LV. [Influence of carbidine on the noradrenaline level in the adrenergic nerve fibers in the peripheral tissues]. Farmakol Toksikol. 1976 Jan-Feb;39(1):25-31. Russian. PubMed PMID: 943316.

18: Barkov NK. [Pharmacological properties of carbidine]. Farmakol Toksikol. 1971 Nov-Dec;34(6):647-50. Russian. PubMed PMID: 5003741.

19: Liubimov BI, Smol'nikova NM, Strekalova SN, Iavorskiĭ AN. [Effect of carbidine on the sex glands of rats chronically exposed to ethanol]. Biull Eksp Biol Med. 1979 Feb;87(2):155-8. Russian. PubMed PMID: 570436.

20: Mitrofanov VS, Runova MF, Barkov NK, Parin VV. [Tolerance for carbidine]. Farmakol Toksikol. 1972 Jul;35(4):410-2. Russian. PubMed PMID: 5050267.