WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558099

CAS#: 497-18-7

Description: Carbohydrazide is a high performance oxygen scavenger which can be used in all types of boilers.

Chemical Structure

CAS# 497-18-7

Theoretical Analysis

MedKoo Cat#: 558099
Name: Carbohydrazide
CAS#: 497-18-7
Chemical Formula: CH6N4O
Exact Mass: 90.05
Molecular Weight: 90.09
Elemental Analysis: C, 13.33; H, 6.71; N, 62.19; O, 17.76

Price and Availability

Size Price Availability Quantity
25.0g USD 230.0 2 Weeks
100.0g USD 430.0 2 Weeks
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Synonym: Carbohydrazide; Carbonohydrazide; Carbazide; Carbodihydrazide;

IUPAC/Chemical Name: Carbonic dihydrazide


InChi Code: InChI=1S/CH6N4O/c2-4-1(6)5-3/h2-3H2,(H2,4,5,6)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 90.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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2: Nogueira TC, Pinheiro AC, Wardell JL, de Souza MV, Abberley JP, Harrison WT. Weak C-H···O and C-H···π hydrogen bonds and π-π stacking interactions in a series of four N'-[(E)-(aryl)methylidene]-N-methyl-2-oxo-1,3-oxazolidine-4-carbohydrazides. Acta Crystallogr C Struct Chem. 2015 Aug;71(Pt 8):647-52. doi: 10.1107/S2053229615012450. Epub 2015 Jul 7. PubMed PMID: 26243408.

3: Qi J, Benipal N, Wang H, Chadderdon DJ, Jiang Y, Wei W, Hu YH, Li W. Metal-catalyst-free carbohydrazide fuel cells with three-dimensional graphene anodes. ChemSusChem. 2015 Apr 13;8(7):1147-50. doi: 10.1002/cssc.201403032. Epub 2014 Dec 3. PubMed PMID: 25469500.

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5: Barman S, You L, Chen R, Codrea V, Kago G, Edupuganti R, Robertus J, Krug RM, Anslyn EV. Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses. Eur J Med Chem. 2014 Jan;71:81-90. doi: 10.1016/j.ejmech.2013.10.063. Epub 2013 Nov 7. PubMed PMID: 24287556; PubMed Central PMCID: PMC4545637.

6: Salvador RR, Bello ML, Barreto IR, Vera MA, Muri EM, Albuquerque S, Dias LR. New carbohydrazide derivatives of 1H-pyrazolo[3,4-b]pyridine and trypanocidal activity. An Acad Bras Cienc. 2016 Oct-Dec;88(4):2341-2348. doi: 10.1590/0001-3765201620160087. Epub 2016 Dec 1. PubMed PMID: 27925033.

7: Siddiki AA, Bairwa VK, Telvekar VN. Synthesis and biological evaluation of novel N' (4-aryloxybenzylidene)- 1H-benzimidazole-2 carbohydrazide derivatives as anti-tubercular agents. Comb Chem High Throughput Screen. 2014;17(7):630-8. PubMed PMID: 24625232.

8: Mirfazli SS, Kobarfard F, Firoozpour L, Asadipour A, Esfahanizadeh M, Tabib K, Shafiee A, Foroumadi A. N-substituted indole carbohydrazide derivatives: synthesis and evaluation of their antiplatelet aggregation activity. Daru. 2014 Sep 20;22:65. doi: 10.1186/s40199-014-0065-6. PubMed PMID: 25238875; PubMed Central PMCID: PMC4172840.

9: Ahmad M, Hameed S, Tahir MN, Israr M, Anwar M, Shah MA, Khan SA, Din G. Synthesis, characterization and biological evaluation of some 5-methylpyrazine carbohydrazide based hydrazones. Pak J Pharm Sci. 2016 May;29(3):811-7. PubMed PMID: 27166526.

10: Jednačak T, Novak P, Hodzic A, Scheibelhofer O, Khinast JG, Plavec J, Sket P, Parlov VJ. Condensation reaction between carbohydrazide and salicylaldehyde: in-line vibrational spectroscopy monitoring and characterization of the reaction products in solution and solid state. Acta Chim Slov. 2014;61(1):161-9. PubMed PMID: 24664340.

11: Hasegawa F, Niidome K, Migihashi C, Murata M, Negoro T, Matsumoto T, Kato K, Fujii A. Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4266-70. doi: 10.1016/j.bmcl.2014.07.025. Epub 2014 Jul 24. PubMed PMID: 25127101.

12: Paulrasu K, Duraikannu A, Palrasu M, Shanmugasundaram A, Kuppusamy M, Thirunavukkarasu B. Synthesis of 4-methyl-N'-(3-alkyl-2r,6c-diarylpiperidin-4-ylidene)-1,2,3-thiadiazole-5-carbohy drazides with antioxidant, antitumor and antimicrobial activities. Org Biomol Chem. 2014 Aug 21;12(31):5911-21. doi: 10.1039/c4ob00739e. PubMed PMID: 24986452.

13: Liu Y, Song H, Huang Y, Li J, Zhao S, Song Y, Yang P, Xiao Z, Liu Y, Li Y, Shang H, Wang Q. Design, synthesis, and antiviral, fungicidal, and insecticidal activities of tetrahydro-β-carboline-3-carbohydrazide derivatives. J Agric Food Chem. 2014 Oct 15;62(41):9987-99. doi: 10.1021/jf503794g. Epub 2014 Oct 3. PubMed PMID: 25280351.

14: Santos PR, Formagio AS, Dias Filho BP, Nakamura CV, Sarragiotto MH, Ueda-Nakamura T. Effect of 1-(phenyl)-N'-(4-methoxybenzylidene)-9H-pyrido[3,4-b] indole-3-carbohydrazide on in vitro poliovirus replication. Acta Pharm. 2015 Mar;65(1):75-81. doi: 10.1515/acph-2015-0004. PubMed PMID: 25781706.

15: Gladkov LL, Gaponenko SV, Shabunya-Klyachkovskaya EV, Shimko AN, Al-Abdullah ES, El-Emam AA. Vibrational spectroscopy of N'-(Adamantan-2-ylidene)thiophene-2-carbohydrazide, a potential antibacterial agent. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jul 15;128:874-9. doi: 10.1016/j.saa.2014.02.071. Epub 2014 Mar 6. PubMed PMID: 24709353.

16: Govindarasu K, Kavitha E, Sundaraganesan N, Suresh M, Syed Ali Padusha M. Synthesis, structural and spectral analysis of (E)-N'-(4-Methoxybenzylidene)pyridine-3-carbohydrazide dihydrate by density functional theory. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 25;135:1123-36. doi: 10.1016/j.saa.2014.08.014. Epub 2014 Aug 19. PubMed PMID: 25189524.

17: Khan I, Tantray MA, Hamid H, Alam MS, Kalam A, Dhulap A. Synthesis of benzimidazole based thiadiazole and carbohydrazide conjugates as glycogen synthase kinase-3β inhibitors with anti-depressant activity. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4020-4. doi: 10.1016/j.bmcl.2016.06.084. Epub 2016 Jun 30. PubMed PMID: 27406796.

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19: Taha M, Sultan S, Nuzar HA, Rahim F, Imran S, Ismail NH, Naz H, Ullah H. Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitors. Bioorg Med Chem. 2016 Aug 15;24(16):3696-704. doi: 10.1016/j.bmc.2016.06.008. Epub 2016 Jun 4. PubMed PMID: 27312423.

20: Sinha R, Sara UV, Khosa RL, Stables J, Jain J. In silico validation and structure activity relationship study of a series of pyridine-3-carbohydrazide derivatives as potential anticonvulsants in generalized and partial seizures. Cent Nerv Syst Agents Med Chem. 2013 Jun;13(2):132-40. PubMed PMID: 24195635.