NSC 184692

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596927

CAS#: 136242-98-3

Description: NSC 184692 is an aminopterin-derivative.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-08-03. Prices are subject to change without notice.

NSC 184692 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 596927
Name: NSC 184692
CAS#: 136242-98-3
Chemical Formula: C22H24N6O5
Exact Mass: 452.1808
Molecular Weight: 452.47
Elemental Analysis: C, 58.40; H, 5.35; N, 18.57; O, 17.68

Synonym: NSC 184692; NSC-184692; NSC184692;

IUPAC/Chemical Name: (4-(((2,4-diamino-5-ethylquinazolin-6-yl)methyl)amino)benzoyl)-L-aspartic acid


InChi Code: InChI=1S/C22H24N6O5/c1-2-14-12(5-8-15-18(14)19(23)28-22(24)27-15)10-25-13-6-3-11(4-7-13)20(31)26-16(21(32)33)9-17(29)30/h3-8,16,25H,2,9-10H2,1H3,(H,26,31)(H,29,30)(H,32,33)(H4,23,24,27,28)/t16-/m0/s1

SMILES Code: O=C(O)C[C@@H](C(O)=O)NC(C1=CC=C(NCC2=C(CC)C3=C(N)N=C(N)N=C3C=C2)C=C1)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Persidsky Y. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14387. [Epub ahead of print] PubMed PMID: 29888782.

2: Luo X, Zhou Q, Du S, Li J, Zhong J, Deng X, Liu Y. Porous Co9S8/Nitrogen, Sulfur-Doped Carbon@Mo2C Dual Catalyst for Efficient Water Splitting. ACS Appl Mater Interfaces. 2018 Jun 8. doi: 10.1021/acsami.8b06166. [Epub ahead of print] PubMed PMID: 29882412.

3: Aydin T, Gurcan C, Taheri H, Yilmazer A. Graphene Based Materials in Neural Tissue Regeneration. Adv Exp Med Biol. 2018 Jun 8. doi: 10.1007/5584_2018_221. [Epub ahead of print] PubMed PMID: 29882208.

4: Damiano S, Sasso A, Accetta R, Monda M, De Luca B, Pavone LM, Belfiore A, Santillo M, Mondola P. Effect of Mutated Cu, Zn Superoxide Dismutase (SOD1(G93A)) on Modulation of Transductional Pathway Mediated by M1 Muscarinic Receptor in SK-N-BE and NSC-34 Cells. Front Physiol. 2018 May 24;9:611. doi: 10.3389/fphys.2018.00611. eCollection 2018. PubMed PMID: 29881358; PubMed Central PMCID: PMC5976866.

5: Fokina A, Wang M, Ilyina A, Klabenkova K, Burakova E, Chelobanov B, Stetsenko D. Analysis of new charge-neutral DNA/RNA analogues phosphoryl guanidine oligonucleotides (PGO) by gel electrophoresis. Anal Biochem. 2018 Jun 2;555:9-11. doi: 10.1016/j.ab.2018.05.027. [Epub ahead of print] PubMed PMID: 29864402.

6: Rim TH, Lee SY, Bae HW, Seong GJ, Kim SS, Kim CY. Increased risk of open-angle glaucoma among patients with diabetes mellitus: a 10-year follow-up nationwide cohort study. Acta Ophthalmol. 2018 Jun 4. doi: 10.1111/aos.13805. [Epub ahead of print] PubMed PMID: 29862632.

7: Chen YR, Hsieh FI, Lien LM, Hu CJ, Jeng JS, Peng GS, Tang SC, Chi NF, Sung YF, Chiou HY. Rheumatoid arthritis significantly increased recurrence risk after ischemic stroke/transient ischemic attack. J Neurol. 2018 Jun 2. doi: 10.1007/s00415-018-8885-9. [Epub ahead of print] PubMed PMID: 29860668.

8: Khalo IV, Konokhova AI, Orlova DY, Trusov KV, Yurkin MA, Bartova E, Kozubek S, Maltsev VP, Chernyshev AV. Nuclear apoptotic volume decrease in individual cells: Confocal microscopy imaging and kinetic modeling. J Theor Biol. 2018 May 30;454:60-69. doi: 10.1016/j.jtbi.2018.05.034. [Epub ahead of print] PubMed PMID: 29859212.

9: Dubey NK, Peng BY, Lin CM, Wang PD, Wang JR, Chan CH, Wei HJ, Deng WP. NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway. Int J Mol Sci. 2018 May 31;19(6). pii: E1625. doi: 10.3390/ijms19061625. PubMed PMID: 29857489.

10: Liu Q, Li Y, Zhou L, Li Y, Xu P, Liu X, Lv Q, Li J, Guo H, Cai H, Sun R, Liu X. GRP78 Promotes Neural Stem Cell Antiapoptosis and Survival in Response to Oxygen-Glucose Deprivation (OGD)/Reoxygenation through PI3K/Akt, ERK1/2, and NF-κB/p65 Pathways. Oxid Med Cell Longev. 2018 Apr 10;2018:3541807. doi: 10.1155/2018/3541807. eCollection 2018. PubMed PMID: 29849883; PubMed Central PMCID: PMC5914129.

11: Asano M, Matsui J, Towle MJ, Wu J, McGonigle S, DE Boisferon MH, Uenaka T, Nomoto K, Littlefield BA. Broad-spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Combination with Anticancer Agents of Differing Mechanisms. Anticancer Res. 2018 Jun;38(6):3375-3385. doi: 10.21873/anticanres.12604. PubMed PMID: 29848686.

12: Fan C, Li X, Zhao Y, Xiao Z, Xue W, Sun J, Li X, Zhuang Y, Chen Y, Dai J. Cetuximab and Taxol co-modified collagen scaffolds show combination effects for the repair of acute spinal cord injury. Biomater Sci. 2018 May 30. doi: 10.1039/c8bm00363g. [Epub ahead of print] PubMed PMID: 29845137.

13: Zhang G, Chen L, Guo X, Wang H, Chen W, Wu G, Gu B, Miao W, Kong J, Jin X, Yi G, You Y, Su X, Gu N. Comparative Analysis of microRNA Expression Profiles of Exosomes Derived from Normal and Hypoxic Preconditioning Human Neural Stem Cells by Next Generation Sequencing. J Biomed Nanotechnol. 2018 Jun 1;14(6):1075-1089. doi: 10.1166/jbn.2018.2567. PubMed PMID: 29843872.

14: Li MJ, Huang JH. Healthcare Seeking Intention if Diagnosed with HIV Among Young MSM in Taiwan: A Theory-Based Comparison by Voluntary Counseling and Testing Experience. AIDS Behav. 2018 May 28. doi: 10.1007/s10461-018-2169-3. [Epub ahead of print] PubMed PMID: 29808258.

15: Shao H, Li T, Zhu R, Xu X, Yu J, Chen S, Song L, Ramakrishna S, Lei Z, Ruan Y, He L. Carbon nanotube multilayered nanocomposites as multifunctional substrates for actuating neuronal differentiation and functions of neural stem cells. Biomaterials. 2018 Aug;175:93-109. doi: 10.1016/j.biomaterials.2018.05.028. Epub 2018 May 18. PubMed PMID: 29804001.

16: Pritchina EA, Kolesov BA. Raman spectra of terephthalic acid crystals in the temperature range 5K-300K. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Sep 5;202:319-323. doi: 10.1016/j.saa.2018.05.065. Epub 2018 May 16. PubMed PMID: 29800896.

17: Zheng C, Chen D, Zhang Y, Bai Y, Huang S, Zheng D, Liang W, She S, Peng X, Wang P, Mo X, Song Q, Lv P, Huang J, Ye RD, Wang Y. FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation. FASEB J. 2018 May 25:fj201800020RRR. doi: 10.1096/fj.201800020RRR. [Epub ahead of print] PubMed PMID: 29799787.

18: Tsarev A, Kolosovsky E, De Leonardis F, Passaro VMN. Numerical Simulation of a Novel Sensing Approach Based on Abnormal Blocking by Periodic Grating Strips near the Silicon Wire Waveguide. Sensors (Basel). 2018 May 25;18(6). pii: E1707. doi: 10.3390/s18061707. PubMed PMID: 29799453.

19: Poplawski GHD, Lie R, Hunt M, Kumamaru H, Kawaguchi R, Lu P, Schäfer MKE, Woodruff G, Robinson J, Canete P, Dulin JN, Geoffroy CG, Menzel L, Zheng B, Coppola G, Tuszynski MH. Adult rat myelin enhances axonal outgrowth from neural stem cells. Sci Transl Med. 2018 May 23;10(442). pii: eaal2563. doi: 10.1126/scitranslmed.aal2563. PubMed PMID: 29794059.

20: Dalmatova SA, Fedorenko AD, Mazalov LN, Asanov IP, Ledneva AY, Tarasenko MS, Enyashin AN, Zaikovskii VI, Fedorov VE. XPS experimental and DFT investigations on solid solutions of Mo(1-x)Re(x)S(2) (0 < x < 0.20). Nanoscale. 2018 May 31;10(21):10232-10240. doi: 10.1039/c8nr01661e. PubMed PMID: 29790553.