Mancozeb
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558090

CAS#: 8018-01-7

Description: Mancozeb is an agricultural ethylene bisdithiocarbamate fungicide.


Chemical Structure

img
Mancozeb
CAS# 8018-01-7

Theoretical Analysis

MedKoo Cat#: 558090
Name: Mancozeb
CAS#: 8018-01-7
Chemical Formula: C8H12MnN4S8Zn
Exact Mass: 538.75
Molecular Weight: 541.01
Elemental Analysis: C, 17.76; H, 2.24; Mn, 10.15; N, 10.36; S, 47.41; Zn, 12.08

Price and Availability

Size Price Availability Quantity
250.0mg USD 210.0 2 Weeks
Bulk inquiry

Synonym: Acarie M; Agrox 16D; Blecar MN; Carmazine; Caswell No. 913A; CCRIS 2495;

IUPAC/Chemical Name: zinc;manganese(2+);N-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate

InChi Key: CHNQZRKUZPNOOH-UHFFFAOYSA-J

InChi Code: InChI=1S/2C4H8N2S4.Mn.Zn/c2*7-3(8)5-1-2-6-4(9)10;;/h2*1-2H2,(H2,5,7,8)(H2,6,9,10);;/q;;2*+2/p-4

SMILES Code: [S-]C(NCCNC([S-])=S)=S.[S-]C(NCCNC([S-])=S)=S.[Zn+2].[Mn+2]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 541.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Pavlovic V, Cekic S, Kamenov B, Ciric M, Krtinic D. The Effect of Ascorbic Acid on Mancozeb-Induced Toxicity in Rat Thymocytes. Folia Biol (Praha). 2015;61(3):116-23. PubMed PMID: 26213857.

2: Balaji B, Rajendar B, Ramanathan M. Quercetin protected isolated human erythrocytes against mancozeb-induced oxidative stress. Toxicol Ind Health. 2014 Jul;30(6):561-9. doi: 10.1177/0748233712462465. Epub 2012 Sep 28. PubMed PMID: 23024109.

3: Srivastava AK, Mishra S, Ali W, Shukla Y. Protective effects of lupeol against mancozeb-induced genotoxicity in cultured human lymphocytes. Phytomedicine. 2016 Jun 15;23(7):714-24. doi: 10.1016/j.phymed.2016.03.010. Epub 2016 Apr 11. PubMed PMID: 27235710.

4: Devi PA, Paramasivam M, Prakasam V. Degradation pattern and risk assessment of carbendazim and mancozeb in mango fruits. Environ Monit Assess. 2015 Jan;187(1):4142. doi: 10.1007/s10661-014-4142-6. Epub 2014 Nov 19. PubMed PMID: 25407993.

5: López-Fernández O, Yáñez R, Rial-Otero R, Simal-Gándara J. Kinetic modelling of mancozeb hydrolysis and photolysis to ethylenethiourea and other by-products in water. Water Res. 2016 Oct 1;102:561-571. doi: 10.1016/j.watres.2016.07.006. Epub 2016 Jul 8. PubMed PMID: 27423406.

6: Majumder S, Shakil NA, Kumar J, Banerjee T, Sinha P, Singh BB, Garg P. Eco-friendly PEG-based controlled release nano-formulations of Mancozeb: Synthesis and bioefficacy evaluation against phytopathogenic fungi Alternaria solani and Sclerotium rolfsii. J Environ Sci Health B. 2016 Dec;51(12):873-880. Epub 2016 Aug 12. PubMed PMID: 27715504.

7: Walia A, Mehta P, Guleria S, Chauhan A, Shirkot CK. Impact of fungicide mancozeb at different application rates on soil microbial populations, soil biological processes, and enzyme activities in soil. ScientificWorldJournal. 2014;2014:702909. doi: 10.1155/2014/702909. Epub 2014 Nov 16. PubMed PMID: 25478598; PubMed Central PMCID: PMC4248338.

8: Mandarapu R, Prakhya BM. In vitro myelotoxic effects of cypermethrin and mancozeb on human hematopoietic progenitor cells. J Immunotoxicol. 2015 Jan-Mar;12(1):48-55. doi: 10.3109/1547691X.2014.880535. Epub 2014 Feb 5. PubMed PMID: 24499300.

9: Hoffman L, Trombetta L, Hardej D. Ethylene bisdithiocarbamate pesticides Maneb and Mancozeb cause metal overload in human colon cells. Environ Toxicol Pharmacol. 2016 Jan;41:78-88. doi: 10.1016/j.etap.2015.11.002. Epub 2015 Nov 7. PubMed PMID: 26650801.

10: Yahia E, Aiche MA, Chouabbia A, Boulakoud MS. SUBCHRONIC MANCOZEB TREATEMENT INDUCED LIVER TOXICITY VIA OXIDATIVE STRESS IN MALE WISTAR RATS. Commun Agric Appl Biol Sci. 2014;79(3):553-9. PubMed PMID: 26080489.

11: Goldoni A, Klauck CR, Da Silva ST, Da Silva MD, Ardenghi PG, Da Silva LB. DNA damage in Wistar rats exposed to dithiocarbamate pesticide mancozeb. Folia Biol (Praha). 2014;60(4):202-4. PubMed PMID: 25152054.

12: Iorio R, Castellucci A, Rossi G, Cinque B, Cifone MG, Macchiarelli G, Cecconi S. Mancozeb affects mitochondrial activity, redox status and ATP production in mouse granulosa cells. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):438-45. doi: 10.1016/j.tiv.2015.09.018. Epub 2015 Sep 25. PubMed PMID: 26407525.

13: Atamaniuk TM, Kubrak OI, Husak VV, Storey KB, Lushchak VI. The Mancozeb-containing carbamate fungicide tattoo induces mild oxidative stress in goldfish brain, liver, and kidney. Environ Toxicol. 2014 Nov;29(11):1227-35. doi: 10.1002/tox.21853. Epub 2013 Feb 23. PubMed PMID: 23436297.

14: van Wendel de Joode B, Barbeau B, Bouchard MF, Mora AM, Skytt Å, Córdoba L, Quesada R, Lundh T, Lindh CH, Mergler D. Manganese concentrations in drinking water from villages near banana plantations with aerial mancozeb spraying in Costa Rica: Results from the Infants' Environmental Health Study (ISA). Environ Pollut. 2016 Aug;215:247-257. doi: 10.1016/j.envpol.2016.04.015. Epub 2016 May 19. PubMed PMID: 27208757.

15: Pandey SP, Mohanty B. The neonicotinoid pesticide imidacloprid and the dithiocarbamate fungicide mancozeb disrupt the pituitary-thyroid axis of a wildlife bird. Chemosphere. 2015 Mar;122:227-234. doi: 10.1016/j.chemosphere.2014.11.061. Epub 2014 Dec 12. PubMed PMID: 25496744.

16: Mirković B, Tanović B, Stević M, Hrustić J, Mihajlović M, Delibašić G, Vukša P. Toxicity of mancozeb, chlorothalonil, captan, fluopyram, boscalid, and difenoconazole to Didymella applanata isolates from Serbia. J Environ Sci Health B. 2015;50(12):845-50. doi: 10.1080/03601234.2015.1062648. Epub 2015 Aug 7. PubMed PMID: 26252498.

17: Harrison Brody A, Chou E, Gray JM, Pokyrwka NJ, Raley-Susman KM. Mancozeb-induced behavioral deficits precede structural neural degeneration. Neurotoxicology. 2013 Jan;34:74-81. doi: 10.1016/j.neuro.2012.10.007. Epub 2012 Oct 24. PubMed PMID: 23103283.

18: Cheng SY, Oh S, Velasco M, Ta C, Montalvo J, Calderone A. RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB. J Biochem Mol Toxicol. 2014 Jul;28(7):302-11. doi: 10.1002/jbt.21566. Epub 2014 Apr 25. PubMed PMID: 24764117.

19: Pirozzi AV, Stellavato A, La Gatta A, Lamberti M, Schiraldi C. Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. Toxicol Lett. 2016 May 13;249:1-4. doi: 10.1016/j.toxlet.2016.03.004. Epub 2016 Mar 22. PubMed PMID: 27016407.

20: van Wendel de Joode B, Mora AM, Córdoba L, Cano JC, Quesada R, Faniband M, Wesseling C, Ruepert C, Oberg M, Eskenazi B, Mergler D, Lindh CH. Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA). Environ Health Perspect. 2014 Dec;122(12):1321-8. doi: 10.1289/ehp.1307679. Epub 2014 Sep 8. Erratum in: Environ Health Perspect. 2014 Dec;122(12):A321. PubMed PMID: 25198283; PubMed Central PMCID: PMC4256696.

Mancozeb

250.0mg / USD 210.0