Acetohydroxamic acid
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MedKoo CAT#: 591442

CAS#: 546-88-3

Description: Acetohydroxamic acid is a biochemical.


Chemical Structure

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Acetohydroxamic acid
CAS# 546-88-3

Theoretical Analysis

MedKoo Cat#: 591442
Name: Acetohydroxamic acid
CAS#: 546-88-3
Chemical Formula: C2H5NO2
Exact Mass: 75.032
Molecular Weight: 75.07
Elemental Analysis: C, 32.00; H, 6.71; N, 18.66; O, 42.63

Price and Availability

Size Price Availability Quantity
5.0g USD 240.0 2 Weeks
10.0g USD 380.0 2 Weeks
50.0g USD 850.0 2 Weeks
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Synonym: Acetohydroxamic acid; NSC 176136; NSC-176136; NSC176136

IUPAC/Chemical Name: Acetamide, N-hydroxy- (9CI)

InChi Key: RRUDCFGSUDOHDG-UHFFFAOYSA-N

InChi Code: InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)

SMILES Code: CC(NO)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 75.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Liu Q, Ni WW, Li Z, Bai CF, Tan DD, Pu CJ, Zhou D, Tian QP, Luo N, Tan KL, Dai L, Yan Y, Pei Y, Li XH, Zhu HL, Xiao ZP. Resolution and evaluation of 3-chlorophenyl-3-hydroxypropionylhydroxamic acid as antivirulence agent with excellent eradication efficacy in Helicobacter pylori infected mice. Eur J Pharm Sci. 2018 May 31. pii: S0928-0987(18)30254-9. doi: 10.1016/j.ejps.2018.05.029. [Epub ahead of print] PubMed PMID: 29860117.

2: Arora R, Issar U, Kakkar R. In Silico study of the active site of Helicobacter pylori urease and its inhibition by hydroxamic acids. J Mol Graph Model. 2018 May 1;83:64-73. doi: 10.1016/j.jmgm.2018.04.018. [Epub ahead of print] PubMed PMID: 29775804.

3: Morrison KD, Jiao Y, Kersting AB, Zavarin M. Reduction of Plutonium(VI) to (V) by Hydroxamate Compounds at Environmentally Relevant pH. Environ Sci Technol. 2018 Jun 5;52(11):6448-6456. doi: 10.1021/acs.est.8b00164. Epub 2018 May 16. PubMed PMID: 29767970.

4: Maimon E, Samuni A, Goldstein S. Nitrogen Dioxide Reaction with Nitroxide Radical Derived from Hydroxamic Acids: The Intermediacy of Acyl Nitroso and Nitroxyl (HNO). J Phys Chem A. 2018 Apr 19;122(15):3747-3753. doi: 10.1021/acs.jpca.8b02300. Epub 2018 Apr 9. PubMed PMID: 29608853.

5: Yang X, Koohi-Moghadam M, Wang R, Chang YY, Woo PCY, Wang J, Li H, Sun H. Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials. PLoS Biol. 2018 Jan 10;16(1):e2003887. doi: 10.1371/journal.pbio.2003887. eCollection 2018 Jan. PubMed PMID: 29320492; PubMed Central PMCID: PMC5779714.

6: Neselioglu S, Ergin M, Erel O. A New Kinetic, Automated Assay to Determine the Ferroxidase Activity of Ceruloplasmin. Anal Sci. 2017;33(12):1339-1344. doi: 10.2116/analsci.33.1339. PubMed PMID: 29225221.

7: Sałdyka M, Mielke Z. Photochemistry of Acetohydroxamic Acid in Solid Argon. FTIR and Theoretical Studies. J Phys Chem A. 2018 Jan 11;122(1):60-71. doi: 10.1021/acs.jpca.7b09461. Epub 2017 Dec 26. PubMed PMID: 29216431.

8: Das P, Gupta G, Velu V, Awasthi R, Dua K, Malipeddi H. Formation of struvite urinary stones and approaches towards the inhibition-A review. Biomed Pharmacother. 2017 Dec;96:361-370. doi: 10.1016/j.biopha.2017.10.015. Epub 2017 Nov 24. Review. PubMed PMID: 29028588.

9: Hassan STS, Švajdlenka E. Biological Evaluation and Molecular Docking of Protocatechuic Acid from Hibiscus sabdariffa L. as a Potent Urease Inhibitor by an ESI-MS Based Method. Molecules. 2017 Oct 11;22(10). pii: E1696. doi: 10.3390/molecules22101696. PubMed PMID: 29019930.

10: Zoidis G, Tsotinis A, Tsatsaroni A, Taylor MC, Kelly JM, Efstathiou A, Smirlis D, Fytas G. Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study. Chem Biol Drug Des. 2018 Feb;91(2):408-421. doi: 10.1111/cbdd.13088. Epub 2017 Sep 18. PubMed PMID: 28834291.

11: Zisman AL. Effectiveness of Treatment Modalities on Kidney Stone Recurrence. Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1699-1708. doi: 10.2215/CJN.11201016. Epub 2017 Aug 22. Review. PubMed PMID: 28830863; PubMed Central PMCID: PMC5628726.

12: Macegoniuk K, Grela E, Biernat M, Psurski M, Gościniak G, Dziełak A, Mucha A, Wietrzyk J, Berlicki Ł, Grabowiecka A. Aminophosphinates against Helicobacter pylori ureolysis-Biochemical and whole-cell inhibition characteristics. PLoS One. 2017 Aug 9;12(8):e0182437. doi: 10.1371/journal.pone.0182437. eCollection 2017. PubMed PMID: 28792967; PubMed Central PMCID: PMC5550016.

13: Liu YH, Lu YL, Liu DZ, Hou WC. Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro. Drug Des Devel Ther. 2017 Jul 13;11:2139-2147. doi: 10.2147/DDDT.S141740. eCollection 2017. PubMed PMID: 28761331; PubMed Central PMCID: PMC5516777.

14: Tan L, Li C, Chen H, Mo Z, Zhou J, Liu Y, Ma Z, Xu Y, Yang X, Xie J, Su Z. Epiberberine, a natural protoberberine alkaloid, inhibits urease of Helicobacter pylori and jack bean: Susceptibility and mechanism. Eur J Pharm Sci. 2017 Dec 15;110:77-86. doi: 10.1016/j.ejps.2017.02.004. Epub 2017 Feb 4. PubMed PMID: 28167234.

15: Zhou JT, Li CL, Tan LH, Xu YF, Liu YH, Mo ZZ, Dou YX, Su R, Su ZR, Huang P, Xie JH. Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism. PLoS One. 2017 Jan 3;12(1):e0168944. doi: 10.1371/journal.pone.0168944. eCollection 2017. PubMed PMID: 28045966; PubMed Central PMCID: PMC5207512.

16: Habala L, Varényi S, Bilková A, Herich P, Valentová J, Kožíšek J, Devínsky F. Antimicrobial Activity and Urease Inhibition of Schiff Bases Derived from Isoniazid and Fluorinated Benzaldehydes and of Their Copper(II) Complexes. Molecules. 2016 Dec 17;21(12). pii: E1742. doi: 10.3390/molecules21121742. PubMed PMID: 27999327.

17: Abdullah MA, Abuo-Rahma GE, Abdelhafez EM, Hassan HA, Abd El-Baky RM. Design, synthesis, molecular docking, anti-Proteus mirabilis and urease inhibition of new fluoroquinolone carboxylic acid derivatives. Bioorg Chem. 2017 Feb;70:1-11. doi: 10.1016/j.bioorg.2016.11.002. Epub 2016 Nov 9. PubMed PMID: 27908539.

18: Meng F, Yang H, Jack C, Zhang H, Moller A, Spivey D, Page RC, Tierney DL, Crowder MW. Biochemical characterization and zinc binding group (ZBGs) inhibition studies on the catalytic domain of MMP7 (cdMMP7). J Inorg Biochem. 2016 Dec;165:7-17. doi: 10.1016/j.jinorgbio.2016.10.005. Epub 2016 Oct 14. PubMed PMID: 27755977.

19: Wang H, Lan T, Zhang X, Zhang D, Bi C, Fan Y. Synthesis, crystal structures, DFT studies, molecular docking and urease inhibition studies of three Ni(II) complexes with a sexidentate N(2)O(4)-donor bis-Schiff base ligand. J Inorg Biochem. 2016 Dec;165:18-24. doi: 10.1016/j.jinorgbio.2016.10.006. Epub 2016 Oct 14. PubMed PMID: 27755976.

20: Grela E, Dziełak A, Szydłowska K, Mucha A, Kafarski P, Grabowiecka AM. Whole-cell Proteus mirabilis urease inhibition by aminophosphinates for the control of struvite formation. J Med Microbiol. 2016 Oct;65(10):1123-1129. doi: 10.1099/jmm.0.000342. Epub 2016 Aug 22. PubMed PMID: 27550502.