IT-9302

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596902

CAS#: 173959-12-1

Description: IT-9302 is a synthetic interleukin-10 agonist; diminishes acute lung injury in rabbits.


Chemical Structure

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IT-9302
CAS# 173959-12-1

Theoretical Analysis

MedKoo Cat#: 596902
Name: IT-9302
CAS#: 173959-12-1
Chemical Formula: C48H82N14O13S2
Exact Mass: 1126.5627
Molecular Weight: 1127.38
Elemental Analysis: C, 51.14; H, 7.33; N, 17.39; O, 18.45; S, 5.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: IT-9302; IT 9302; IT9302;

IUPAC/Chemical Name: L-alanyl-L-tyrosyl-L-methionyl-L-threonyl-L-methionyl-L-lysyl-L-isoleucyl-L-arginyl-L-asparagine

InChi Key: GTORPNRZTBKYJB-AIEIIIEWSA-N

InChi Code: InChI=1S/C48H82N14O13S2/c1-7-25(2)37(45(72)57-31(12-10-20-54-48(52)53)40(67)60-35(47(74)75)24-36(51)65)61-42(69)30(11-8-9-19-49)55-41(68)32(17-21-76-5)58-46(73)38(27(4)63)62-43(70)33(18-22-77-6)56-44(71)34(59-39(66)26(3)50)23-28-13-15-29(64)16-14-28/h13-16,25-27,30-35,37-38,63-64H,7-12,17-24,49-50H2,1-6H3,(H2,51,65)(H,55,68)(H,56,71)(H,57,72)(H,58,73)(H,59,66)(H,60,67)(H,61,69)(H,62,70)(H,74,75)(H4,52,53,54)/t25-,26-,27+,30-,31-,32-,33-,34-,35-,37-,38-/m0/s1

SMILES Code: O=C(N)C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H]([C@H](O)C)NC([C@H](CCSC)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](C)N)=O)=O)=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 1127.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: López MN, Pesce B, Kurte M, Pérez C, Segal G, Roa J, Aguillón JC, Mendoza-Naranjo A, Gesser B, Larsen C, Villablanca A, Choudhury A, Kiessling R, Salazar-Onfray F. A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ tolerogenic dendritic cells. Immunobiology. 2011 Oct;216(10):1117-26. doi: 10.1016/j.imbio.2011.04.006. Epub 2011 Apr 22. PubMed PMID: 21601308.

2: Salazar-Onfray F, López MN, Mendoza-Naranjo A. Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):171-82. Epub 2007 Feb 27. Review. PubMed PMID: 17329145.

3: Kurte M, López M, Aguirre A, Escobar A, Aguillón JC, Charo J, Larsen CG, Kiessling R, Salazar-Onfray F. A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and Transporter associated with Antigen Processing 1/2 in human melanoma cells. J Immunol. 2004 Aug 1;173(3):1731-7. PubMed PMID: 15265902.

4: Osman MO, Gesser B, Mortensen JT, Matsushima K, Jensen SL, Larsen CG. Profiles of pro-inflammatory cytokines in the serum of rabbits after experimentally induced acute pancreatitis. Cytokine. 2002 Jan 7;17(1):53-9. PubMed PMID: 11886171.

5: Vestergaard C, Kirstejn N, Gesser B, Mortensen JT, Matsushima K, Larsen CG. IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: a possible mechanism in the inflammatory reaction of atopic dermatitis. J Dermatol Sci. 2001 May;26(1):46-54. PubMed PMID: 11323220.

6: Osman MO, Jacobsen NO, Kristensen JU, Deleuran B, Gesser B, Larsen CG, Jensen SL. IT 9302, a synthetic interleukin-10 agonist, diminishes acute lung injury in rabbits with acute necrotizing pancreatitis. Surgery. 1998 Sep;124(3):584-92. PubMed PMID: 9736913.