AH 22921

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591435

CAS#: 123122-56-5

Description: AH 22921 is a thromboxane A2 antagonist.


Chemical Structure

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AH 22921
CAS# 123122-56-5

Theoretical Analysis

MedKoo Cat#: 591435
Name: AH 22921
CAS#: 123122-56-5
Chemical Formula: C29H35NO5
Exact Mass: 477.25
Molecular Weight: 477.600
Elemental Analysis: C, 72.93; H, 7.39; N, 2.93; O, 16.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AH 22921; AH22921; AH-22921

IUPAC/Chemical Name: 5-Heptenoic acid, 7-(5-((1,1'-biphenyl)-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl)-, (1alpha(Z),2beta,5alpha)-

InChi Key: UWQXOMOFJWMVPM-BJHZJVKSSA-N

InChi Code: InChI=1S/C29H35NO5/c31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30/h1,3-6,8-9,12-15,25,27,29H,2,7,10-11,16-21H2,(H,32,33)/b6-1-/t25-,27-,29+/m0/s1

SMILES Code: O=C(O)CCC/C=C\C[C@@H]1[C@@H](N2CCOCC2)C(C[C@@H]1OCC3=CC=C(C4=CC=CC=C4)C=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 477.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sharif NA, Xu SX. Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates. J Pharm Pharmacol. 2004 Feb;56(2):197-203. PubMed PMID: 15005878.

2: Crider JY, Griffin BW, Sharif NA. Endogenous EP4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells: pharmacological characterization. Prostaglandins Leukot Essent Fatty Acids. 2000 Jan;62(1):21-6. PubMed PMID: 10765975.

3: Coleman RA, Mallett A, Sheldrick RL. EP4-receptors and cyclic AMP in pig venous smooth muscle: evidence with agonists and the EP4-antagonist, AH22921. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:241-6. PubMed PMID: 7732844.

4: Boura AL, Gude NM, King RG, Mak KK, Walters WA. Characterization of thromboxane A2 receptors in the human fetal placental vessels and umbilical vein. Clin Exp Pharmacol Physiol. 1986 Jan;13(1):83-6. PubMed PMID: 3011331.