U 89360E

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MedKoo CAT#: 596885

CAS#: 161897-65-0

Description: U 89360E is a peptidic inhibitor.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-09-23. Prices are subject to change without notice.

U 89360E is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 596885
Name: U 89360E
CAS#: 161897-65-0
Chemical Formula: C28H52N8O6
Exact Mass: 596.401
Molecular Weight: 596.77
Elemental Analysis: C, 56.35; H, 8.78; N, 18.78; O, 16.09


Synonym: U 89360E; U-89360E; U89360E;

IUPAC/Chemical Name: (2S)-2-((4S,5S)-5-acetamido-6-cyclohexyl-4-hydroxy-2-isopropylhexanamido)-N1-((S)-1-amino-5-guanidino-1-oxopentan-2-yl)pentanediamide

InChi Key: XTOQWMLQBSGKOK-FBUUKJIQSA-N

InChi Code: InChI=1S/C28H52N8O6/c1-16(2)19(15-23(38)22(34-17(3)37)14-18-8-5-4-6-9-18)26(41)36-21(11-12-24(29)39)27(42)35-20(25(30)40)10-7-13-33-28(31)32/h16,18-23,38H,4-15H2,1-3H3,(H2,29,39)(H2,30,40)(H,34,37)(H,35,42)(H,36,41)(H4,31,32,33)/t19?,20-,21-,22-,23-/m0/s1

SMILES Code: N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CCC(N)=O)NC(C(C(C)C)C[C@H](O)[C@@H](NC(C)=O)CC1CCCCC1)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Hong L, Hartsuck JA, Foundling S, Ermolieff J, Tang J. Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant. Protein Sci. 1998 Feb;7(2):300-5. PubMed PMID: 9521105; PubMed Central PMCID: PMC2143907.

2: Hong L, Zhang XJ, Foundling S, Hartsuck JA, Tang J. Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs. FEBS Lett. 1997 Dec 22;420(1):11-6. PubMed PMID: 9450540.

3: Hong L, Treharne A, Hartsuck JA, Foundling S, Tang J. Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases. Biochemistry. 1996 Aug 20;35(33):10627-33. PubMed PMID: 8718851.