WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562986
CAS#: 1529814-60-5
Description: PS121912 is a potent and selective VDR-coactivator inhibitor.
MedKoo Cat#: 562986
Name: PS121912
CAS#: 1529814-60-5
Chemical Formula: C24H21F3N2O
Exact Mass: 410.1606
Molecular Weight: 410.44
Elemental Analysis: C, 70.23; H, 5.16; F, 13.89; N, 6.83; O, 3.90
This product is not in stock, which may be available by custom synthesis.
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Synonym: PS121912; PS-121912; PS 121912;
IUPAC/Chemical Name: [(4-Methoxy-phenyl)-(2-methyl-1H-indol-3-yl)-methyl]-(4-trifluoromethyl-phenyl)-amine
InChi Key: NNTQFFZNUZBJND-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H21F3N2O/c1-15-22(20-5-3-4-6-21(20)28-15)23(16-7-13-19(30-2)14-8-16)29-18-11-9-17(10-12-18)24(25,26)27/h3-14,23,28-29H,1-2H3
SMILES Code: FC(C1=CC=C(NC(C2=CC=C(OC)C=C2)C3=C(C)NC4=C3C=CC=C4)C=C1)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 410.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Res. 2015 Nov;35(11):6001-7. PubMed PMID: 26504023; PubMed Central PMCID: PMC4633305.
2: Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014 Oct;74(4):787-98. doi: 10.1007/s00280-014-2549-y. Epub 2014 Aug 9. PubMed PMID: 25107568; PubMed Central PMCID: PMC4177010.
3: Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. Development of novel Vitamin D Receptor-Coactivator Inhibitors. ACS Med Chem Lett. 2014 Feb 13;5(2):199-204. PubMed PMID: 24799995; PubMed Central PMCID: PMC4007349.
